Lymph node core needle biopsy in lymphoproliferative disorders—Authors’ reply to Al‐Abbadi and colleagues

Pizzi, Marco; Agostinelli, Claudio; Santoro, Luisa; Sbaraglia, Marta; Bertuzzi, Clara; Santo, Luca Dal; Friziero, Alberto; Zinzani, Pier Luigi; Tos, Angelo Paolo Dei; Sabattini, Elena

doi:10.1111/ejh.13648

Cited by 2 publications

(1 citation statement)

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“…Several studies have addressed the accuracy of LNCB‐based diagnoses, obtaining conflicting and disputable results 5–8 . In most series, the diagnostic yield of LNCB is high, with actionable diagnoses in 80%–90% of cases 9 .…”

Section: Introductionmentioning

confidence: 99%

Higher accuracy of surgical over core needle biopsy for the diagnosis of lymphoproliferative disorders

Pizzi

Sbaraglia

Santo

et al. 2023

Int J Lab Hematology

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Introduction The diagnosis of lymphoproliferative disorders (LPDs) is based on histological evaluation of representative tissue samples. Despite surgical excision biopsies (SEBs) are reference procedures for such diagnoses, lymph node core needle biopsies (LNCBs) are increasingly performed. The diagnostic yield of LNCB is, however, debated and few studies have compared the reproducibility of LNCB and SEB findings. Methods To address the diagnostic value of LNCB and SEB, the present study considered a retrospective series of 43 paired LNCB/SEB samples. After histological revision, concordance rates between matched LNCB/SEB samples were evaluated, assuming SEB as gold standard procedure. The actionability of LNCB and SEB‐based diagnoses (i.e., relevance for planning further medical interventions) was also assessed. Results Overall, LNCB provided actionable diagnoses in 39/43 (90.7%) cases, but a consistent subset of them (7/39 [17.9%]) turned out to be wrong at SEB. The cumulative diagnostic inaccuracy of LNCB (i.e., inadequate samples plus wrong diagnoses) was 25.6% and the mean diagnostic delay in such cases was 54.2 days. Conclusions Although limited by selection biases due to its retrospective nature, this study highlights the intrinsic limitations of LNCB for the diagnosis of LPDs. SEB remains the gold standard procedure and should be performed in all suitable cases.

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Section: Introductionmentioning

confidence: 99%