Lymph Node Infarction in Classical Hodgkin's Lymphoma

Mori, Eiichiro; Enomoto, Yasunori; Nakamine, Hirokazu; Kasai, Takahiko; Takeda, Maiko; Takano, Mitsuo; Morita, Keiko; Koizumi, Toshizo; Nonomura, Akitaka

doi:10.3960/jslrt.52.35

Cited by 4 publications

(3 citation statements)

References 13 publications

(15 reference statements)

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“…There are studies that found immunostainings of both necrotic tissues and viable tissues yield similar results and were used in the diagnosis of lesions [9]. Mori et al [10] studied the expression of IHC markers, CD3, CD20, CD30,CD15, LMP1, etc. and found expression of immunomarkers in the infracted areas and concluded that at least on some occasions IHC can be informative for accurate diagnosis in lymphoid neoplasms.…”

Section: Discussionmentioning

confidence: 99%

Role of Immunohistochemistry in Acute Leukemias with Myelonecrosis

Kalaivani

Saranya

Kar

et al. 2018

Indian J Hematol Blood Transfus

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Myelonecrosisis a rare antemortem finding most commonly seen in haematopoeitic neoplasms, especially in acute leukemia. When myelonecrosis occurs at the time of presentation, it imposes certain diagnostic issues in sub categorization of leukemias which is necessary for therapeutic as well as prognostic purposes. Flow cytometry, though is a powerful modality, has its own limitations especially when the cells are not fresh and viable; and when the specimen is not of adequate cellularity which is usual in cases of myelonecrosis. In such situations, immunocytochemistry (ICC) or immunohistochemistry (IHC) may play a major role in lineage specification in leukemias as the necrosed marrow with the ghost cells can still retain the antigenicity for certain immunomarkers. Four such interesting cases of common B acute lymphoblastic leukemia (ALL) where IHC was used for diagnosis were included. ICC and IHC done on the necrosed marrow contributed to the diagnosis of ALL in all the four cases and contributed to subsequent management. ICC and IHC if contributory can play a major role in identifying the primary cause of myelonecrosis as the ghost cells can retain the antigenicity despite being morphologically non-viable.

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Section: Discussionmentioning

confidence: 99%

Role of Immunohistochemistry in Acute Leukemias with Myelonecrosis

Kalaivani

Saranya

Kar

et al. 2018

Indian J Hematol Blood Transfus

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“…Massive infarction of the lymph node should raise the suspicion of lymphoma and must be carefully investigated [ 11 ]. Based on Jiang’s immunohistochemistry diffuse, large B-cell lymphoma, follicular lymphoma, and anaplastic large cell lymphoma were the most common types [ 9 , 12 ].…”

Section: Discussionmentioning

confidence: 99%

Diagnostic Difficulties in Evaluation of Neck Masses – Idiopathic Lymph Node Infarction

Subicz¹,

Sztanó

Krasznai³

et al. 2018

JMedLife

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Palpable neck masses are often the only signs of patients visiting their ENT specialists. Lymphadenopathy may be a primary or secondary manifestation of numerous benign and malignant disorders. The medical history, physical examination, imaging and pathological examination may help to set the appropriate diagnosis. Lymph node infarction is a very rare entity among the various pathologies involving the lymph nodes. We hereby present three cases, in which infarction was the only symptom, no associated condition occurred.

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“…5,6,7,8 In previous reports, lymph node infarction accompanied by Hodgkin lymphoma was rare. 5,6,9 Even in infarcted lymph nodes, L26 (anti-CD20 antibody) has been found to be of diagnostic value, 7,8,10 especially for diagnosis of B-cell lymphoma. In our case, L26 staining was negative in both the infarcted sample and in the sample that was used to diagnose Hodgkin lymphoma.…”

Section: Xxxxx Xxxxx Xxxxxmentioning

confidence: 99%