Lymph node involvement in macroscopic medullary thyroid carcinoma

Tamagnini, P; Iacobone, Maurizio; Sébag, F.; Marcy, M.; Micco, C. De; Henry, JF

doi:10.1002/bjs.4860

Cited by 27 publications

(21 citation statements)

References 38 publications

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“…For comparative analyses of 115/120 cases of the Viennese cohort, the mitotic count [per 20 × 0.2 mm²], growth patterns and tumour cell types were assessed according to the WHO classification, and the peritumoral infiltration patterns as described by Tamagnini et al. 9 In addition, the presence of vascular invasion, necrosis, entrapped follicles, amyloid, calcification, lymphocytes in the tumour and inflammation in the pre‐existing thyroid tissue were evaluated.…”

Section: Correlation With Other Morphological Parametersmentioning

confidence: 99%

Desmoplasia in medullary thyroid carcinoma: a reliable indicator of metastatic potential

et al. 2008

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Section: Correlation With Other Morphological Parametersmentioning

confidence: 99%

Desmoplasia in medullary thyroid carcinoma: a reliable indicator of metastatic potential

et al. 2008

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“…These data emphasize the significance of the unresolved problem about the role of cervical lymph node dissection in the management of patients at risk for the development of hereditary MTC. The radicality during initial surgery is of utmost importance, because of its influence on the outcome of patients with hereditary MTC (Ellenhom et al 1993, Kallinowski et al 1993, Dralle et al 1995, Tamagnini et al 2005.…”

Section: The Role Of Cervical Lymph Node Dissectionmentioning

confidence: 99%

The genetic basis of hereditary medullary thyroid cancer: clinical implications for the surgeon, with a particular emphasis on the role of prophylactic thyroidectomy

Sakorafas¹,

Friess²,

Peros³

2008

Endocrine Related Cancer

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Medullary thyroid cancer (MTC) may occur either sporadically or on a hereditary basis. Hereditary MTC may be observed with either multiple endocrine neoplasia syndromes (MEN 2A and MEN 2B) or as familial MTC (FMTC). Despite the rarity of these syndromes, early diagnosis is especially important, since MTC is a lethal disease if not promptly and appropriately treated. Recently, the development of genetic testing and direct DNA analysis allows the identification of asymptomatic patients. Surgical prophylaxis should be considered in these cases, ideally to prevent the development of MTC. During the recent decade, the concept of 'codon-directed' timing of prophylactic surgery emerged as a reasonable strategy in the management of these patients. Currently, genetic analysis offers the possibility to define genotype-phenotype correlations and to adjust the time of prophylactic surgery. Hereditary MTC is a model of genetically determined cancer in which both diagnostic and therapeutic strategies rely on the identification of specific mutations.Endocrine-Related Cancer (2008) 15 871-884

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“…• there does not seem to be any preoperative predictive factor of LN involvement [24]. The size of the MTC tumor, whether determined on preoperative imaging workup or during operation, is not sufficient to decide on the extent of LN dissection.…”

Section: Extent Of Ln Dissectionmentioning

confidence: 98%

Surgical management of sporadic medullary thyroid cancer

Noullet

Trésallet

Godiris-Petit

et al. 2011

Journal of Visceral Surgery

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Inherited and sporadic medullary thyroid cancer (MTC) is a rare carcinoma. Sporadic MTCs represent 70% of cases. Diagnosis is currently made with the routine use of serum calcitonin (CT) measurements to screen patients with nodular thyroid disease. Surgery is the only curative treatment of MTC and since cervical lymph nodes metastases are frequent and can occur at an early stage, a standardized lymph node dissection should be associated to total thyroidectomy. However, the extent of lymphadenectomy remains debated. Prognosis of MTC is related to both the stage of the disease and the extent of initial surgery. When tumor remnants persist after surgery, there are very few therapeutic alternatives, and these are generally of limited curative value.

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Lymph node involvement in macroscopic medullary thyroid carcinoma

Abstract: There were no preoperative factors that predicted node status for MTC larger than 1 cm in this series. Total thyroidectomy and nodal dissection remains the optimal treatment.

Cited by 27 publications

References 38 publications

Desmoplasia in medullary thyroid carcinoma: a reliable indicator of metastatic potential

Desmoplasia in medullary thyroid carcinoma: a reliable indicator of metastatic potential

The genetic basis of hereditary medullary thyroid cancer: clinical implications for the surgeon, with a particular emphasis on the role of prophylactic thyroidectomy

Surgical management of sporadic medullary thyroid cancer

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