Lymph node metastases: importance of detection and treatment strategies

Obinu, Antonella; Gavini, Elisabetta; Rassu, Giovanna; Maestri, Marcello; Bonferoni, Maria Cristina; Giunchedi, Paolo

doi:10.1080/17425247.2018.1446937

Cited by 30 publications

(13 citation statements)

References 101 publications

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“…In this study, inter-reader variance of the elastography was avoided by performing assessment by at least three doctors. Twenty-three patients with superficial tuberculous lymphadenitis were type II, which was consistent with previous studies [ 25 , 26 ]. When the lymph nodes were primarily blue on the elastography, the pathological specimens were mostly hard with granulomas and large amounts of caseous necrotic tissue.…”

Section: Discussionsupporting

confidence: 91%

The value of multimodal ultrasonography in differential diagnosis of tuberculous and non-tuberculous superficial lymphadenitis

Chu

Zhang

et al. 2021

BMC Surg

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Background To investigate the value of multimodal ultrasonography in differentiating tuberculosis from other lymphadenopathy. Methods Sixty consecutive patients with superficial lymphadenopathy treated at our hospital from January 2017 to December 2018 were categorized into four types based on the color Doppler ultrasound, five types based on contrast-enhanced ultrasound, and five types based on elastography. Sensitivity and specificity were calculated of all the three imaging, including color Doppler examination, contrast-enhanced ultrasound and one individual multimodal method, for detecting lymph nodes. Results A total of 60 patients were included in the final analysis. Of those, Mycobacterium tuberculosis was positive in 38 patients and negative in 22 patients. Among the 38 patients who were positive for Mycobacterium tuberculosis, of which 23 had a history of pulmonary tuberculosis, accounting for 60.53% of the positive cases, and the remaining patients did not combine lesions of other organs. Among the 60 superficial lymph nodes, 63.3% presented with tuberculous lymphadenitis. The sensitivity, specificity, and accuracy of the color Doppler examination were 73.68%, 68.18%, and 71.67%, respectively. The sensitivity, specificity and accuracy of contrast-enhanced ultrasound were 89.47%, 63.64% and 80.00%, respectively. The sensitivity, specificity and accuracy of the elastography were 63.16%, 63.64% and 63.33%, respectively. The sensitivity, specificity and accuracy of one individual multimodal method were 42.11%, 95.45% and 61.67%, respectively. The sensitivity, specificity and accuracy of all modes combined were 100.00%, 27.27% and 73.33%, respectively. Conclusion Multimodal ultrasonography has high predictive value for the differential diagnosis of superficial tuberculous lymphadenitis.

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Section: Discussionsupporting

confidence: 91%

The value of multimodal ultrasonography in differential diagnosis of tuberculous and non-tuberculous superficial lymphadenitis

Chu

Zhang

et al. 2021

BMC Surg

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“…In addition, homeostasis of the interstitial fluid is maintained by the microcirculation system, based on permeation from the blood vessels and subsequent absorption by the lymphatic vessels [27] . More relevant to cancer, the lymphatic draining system not only plays a critical role in metastasis [28] , but it also provides a preferential recycling route to most administered anti-tumor drugs in vivo [29] .…”

mentioning

confidence: 99%

A Tumor‐on‐a‐Chip System with Bioprinted Blood and Lymphatic Vessel Pair

Cao

Ashfaq

Cheng

et al. 2019

Adv Funct Materials

142

123

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Current in vitro anti-tumor drug screening strategies are insufficiently portrayed lacking true perfusion and draining microcirculation systems, which may post significant limitation in reproducing the transport kinetics of cancer therapeutics explicitly. Herein, we report the fabrication of an improved tumor model consisting of bioprinted hollow blood vessel and lymphatic vessel pair, hosted in a threedimensional (3D) tumor microenvironment-mimetic hydrogel matrix, termed as the tumor-on-a-chip with bioprinted blood and lymphatic vessel pair (TOC-BBL). The bioprinted blood vessel was perfusable channel with opening on both ends while the bioprinted lymphatic vessel was blinded on one end, both of which were embedded in a hydrogel tumor mass, with vessel permeability individually tunable through optimization of the composition of the bioinks. We demonstrated that systems with different combinations of these bioprinted blood/lymphatic vessels exhibited varying levels of diffusion profiles for biomolecules and anti-cancer drugs. Our TOC-BBL platform mimicking the natural pathway of drug-tumor interactions would have the drug introduced through the perfusable blood vessel, cross the vascular wall into the tumor tissue via diffusion, and eventually drained into the lymphatic vessel along with the carrier flow. Our results suggested that this unique in vitro tumor model containing the bioprinted blood/lymphatic vessel pair may have the capacity of simulating the complex transport mechanisms of certain pharmaceutical compounds inside the tumor microenvironment, potentially providing improved accuracy in future cancer drug screening.

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“…Nanomedicine is based on the peculiar properties of nanoscale carriers that are designed to target and deliver drugs and/or diagnostic agents to specific organs and tissues [20][21][22][23][24]. Therefore, nanotechnology has important applications in cancer diagnosis and therapy [25][26][27][28]. Different kinds of nanocarriers can be used.…”

Section: Introductionmentioning

confidence: 99%

Chitosan Nanoparticles for Therapy and Theranostics of Hepatocellular Carcinoma (HCC) and Liver-Targeting

et al. 2020

Self Cite

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Chitosan nanoparticles are well-known delivery systems widely used as polymeric carriers in the field of nanomedicine. Chitosan is a carbohydrate of natural origin: it is a biodegradable, biocompatible, mucoadhesive, polycationic polymer and it is endowed with penetration enhancer properties. Furthermore, it can be easily derivatized. Hepatocellular carcinoma (HCC) represents a remarkable health problem because current therapies, that include surgery, liver transplantation, trans-arterial embolization, chemoembolization and chemotherapy, present significant limitations due to the high risk of recurrence, to a lack of drug selectivity and to other serious side effects. Therefore, there is the need for new therapeutic strategies and for improving the liver-targeting to HCC. Nanomedicine consists in the use of nanoscale carriers as delivery systems to target and deliver drugs and/or diagnostic agents to specific organs or tissues. Chitosan and its derivatives can be successfully used in the preparation of nanoparticles that, for their peculiar surface-properties, can specifically interact with liver tumor, by passive and active targeting. This review concerns the use of chitosan nanoparticles for the therapy and theranostics of HCC and liver-targeting.

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Lymph node metastases: importance of detection and treatment strategies

Cited by 30 publications

References 101 publications

The value of multimodal ultrasonography in differential diagnosis of tuberculous and non-tuberculous superficial lymphadenitis

The value of multimodal ultrasonography in differential diagnosis of tuberculous and non-tuberculous superficial lymphadenitis

A Tumor‐on‐a‐Chip System with Bioprinted Blood and Lymphatic Vessel Pair

Chitosan Nanoparticles for Therapy and Theranostics of Hepatocellular Carcinoma (HCC) and Liver-Targeting

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