Lymph Node Metastasis of Soft Tissue Tumors

Loya, Anand C; Prayaga, Aruna K; Arora, Anu; Challa, Sundaram; Rao, I. Satish; Uppin, Shantveer G; Raju, G. S.; Surath, Anjna; Rajappa, R Senthil

doi:10.1159/000325708

Cited by 27 publications

(33 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…8 In a subsequent study by Loya et al of 241 patients with soft-tissue tumors, 19 showed lymph node involvement by metastases, with 12 (63%) occurring synchronously with the primary tumor. 7 The soft-tissue tumor most likely to metastasize to lymph nodes in this study was rhabdomyosarcoma.…”

Section: Discussionmentioning

confidence: 70%

“…Cytologic features of epithelioid sarcoma include a hypercellular smear composed of round to polygonal cells with areas of necroinflammatory debris; unlike ASRMS, however, the nuclei exhibit significant pleomorphism, prominent nucleoli and nuclear grooves, and a dense intercellular matrix would not be expected. 7,13 Extraskeletal Ewing's sarcoma exhibits a discrete small, round cell population; however, additional features such as cytoplasmic vacuoles, HomerWright rosettes, and immunoreactivity for CD99 are typically seen. 7,13 Biphasic synovial sarcoma shows foci with round or polygonal epithelial cells, but spindle cell areas as well as immunoreactivity for cytokeratin markers are also expected, and the dense intercellular matrix seen in ASRMS is not a typical feature.…”

Section: Discussionmentioning

confidence: 99%

“…7,13 Extraskeletal Ewing's sarcoma exhibits a discrete small, round cell population; however, additional features such as cytoplasmic vacuoles, HomerWright rosettes, and immunoreactivity for CD99 are typically seen. 7,13 Biphasic synovial sarcoma shows foci with round or polygonal epithelial cells, but spindle cell areas as well as immunoreactivity for cytokeratin markers are also expected, and the dense intercellular matrix seen in ASRMS is not a typical feature. 7,13 Small-cell neuroendocrine carcinoma is composed of small, round cells with dense chromatin and absent or inconspicuous nucleoli; unlike ASRMS, these tumors are immunoreactive for epithelial and neuroendocrine markers.…”

Section: Discussionmentioning

confidence: 99%

“…3,5 Lymph node metastasis of soft-tissue sarcoma is an infrequent event, with a reported incidence of 2.6-5%. 6,7 The overall incidence is somewhat higher in RMSs, ranging from 12.2 to 14.8% in collected reviews, whereas Fong et al found an increased incidence of the ERMS subtype metastasizing to lymph nodes.nosed on FNA cytology. We report here, a case of biopsy proven adult sclerosing rhabdomyosarcoma of the lower extremity, with subsequent inguinal lymph node involvement confirmed by FNA cytology.…”

mentioning

confidence: 99%

See 3 more Smart Citations

Fine‐needle aspiration diagnosis of a metastatic adult sclerosing rhabdomyosarcoma in a lymph node

Cantley

Cimbaluk

Reddy

et al. 2010

Diagnostic Cytopathology

View full text Add to dashboard Cite

Adult sclerosing rhabdomyosarcoma (ASRMS) is a rare variant of rhabdomyosarcoma with a characteristic histological appearance of small, round cells in a dense, hyalinized stroma. Although nodal metastases of soft-tissue sarcomas are considered uncommon, up to 5% overall are associated with lymph node metastases. Nonetheless, there is little literature on the cytologic characteristics of metastatic soft-tissue sarcomas in lymph nodes, and to our knowledge, there are no reports of nodal metastasis of ASRMS diagnosed by fine-needle aspiration (FNA) cytology. We report here a 55-year-old woman who presented with a right thigh mass and associated ipsilateral inguinal lymphadenopathy. Biopsy of the mass revealed a uniform population of small, round cells in a dense, sclerotic background. A diagnosis of ASRMS was rendered. Subsequently, the patient underwent FNA of an enlarged inguinal lymph node, which revealed an identical population of small, round cells in a dense, myxoid background. This case highlights the cytologic features of a rare form of rhabdomyosarcoma, and emphasizes the utility of FNA in the assessment of lymphadenopathy in the setting of a soft-tissue sarcoma.

show abstract

Section: Discussionmentioning

confidence: 70%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

Fine‐needle aspiration diagnosis of a metastatic adult sclerosing rhabdomyosarcoma in a lymph node

Cantley

Cimbaluk

Reddy

et al. 2010

Diagnostic Cytopathology

View full text Add to dashboard Cite

show abstract

“…[2,22,23] Rates for oral cavity, pharynx, oesophagus and male larynx are highest in India, probably due to the use of multiple tobacco products. Metastases from the lung, breast malignancy often due to lack of awareness about the malignancy and poor treatment compliance due to lower socioeconomic condition and illiteracy with social stigma [27] . Although we had a very low number of 25/266 cases (9.4%) with histopathological correlation, we could diagnose reactive lymphadenopathy, sinus histiocytosis, chronic granulomatous lesion suggestive of tuberculosis and malignant lesions with high accuracy.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Fine Needle Aspiration Cytology of Cervical Lymphadenopathies at Tertiary Care Center

Gojiya

Goswami

Shah

2018

APALM

View full text Add to dashboard Cite

Background: Lymphadenopathies in the neck region is the most frequently sent for the cytology evaluation from the clinicians, involvement in regional and systemic diseases and their easy accessibility make the FNAC as a primary workup. Inflammatory and immune reactions are the most frequent causes of lymph node enlargement and are self limiting in majority of cases. Tuberculosis can also be diagnosed by cytology of affected lymph nodes. With the advent of FNAC, most of the inflammatory, reactive and neoplastic conditions can be diagnosed without biopsy. It has the advantage that it can be done safely, rapidly and cheaply with minimal trauma at an outpatient setup or at the bedside.Methods: This study was conducted at cytology section of pathology department of our institute. Patients from ENT, Surgery, Medicine, Pulmonary medicine departments were referred for FNAC. Written informed consent was obtained from all patients. It included patients with lymphadenopathies in cervical region. FNAC was conducted with the help of a 24 guage disposable needle attached to a 10cc syringe. Conclusion:FNAC is a safe, simple & inexpensive primary immediate diagnostic procedure and workup for lymph node enlargements, especially in cervical lymphadenopathies where biopsies are not done routinely.

show abstract