Lymph node ratio as prognostic variable in oral squamous cell carcinomas: Systematic review and meta-analysis

Huang, Ting; Li, Kar Yan; Choi, Wonyoung

doi:10.1016/j.oraloncology.2018.12.032

Cited by 65 publications

(58 citation statements)

References 77 publications

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“…As there are no generally accepted standards for measuring study quality, this form was derived and adapted from the work of de Graeff and Huang et al…”

Section: Methodsmentioning

confidence: 99%

The prognostic value of anterior commissure involvement in T1 glottic cancer: A systematic review and meta‐analysis

Tulli

Bondi

et al. 2019

The Laryngoscope

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Objective The anterior commissure is considered a laryngeal subsite, but it is not taken into account in the current T‐staging system. The impact of anterior commissure involvement (ACI) on the oncologic outcomes of T1 glottic tumors has not been well defined and remains controversial. The aim of this study was to assess the influence of ACI in the prognosis of T1 glottic tumors. Methods A systematic review and meta‐analysis of observational studies was performed by including studies published up to July 2019. Studies were selected if they had investigated the local control rate (LCR) at 5 years of clinical stage I (T1 and N0) glottic squamous cell carcinoma with and without ACI. The difference in LCR at 5 years between T1 glottic tumors without and with ACI was evaluated. Results The meta‐analysis showed that the difference in LCR at 5 years between T1 glottic tumors without and with ACI is 12% (95% confidence interval: 8%‐16%, p < 0,0001, I2 = 34.81%). Conclusions Our study pointed out that the anterior commissure involvement is a negative prognostic factor in LCR at 5 years for T1 glottic tumors. Our results suggest the need to consider ACI in the T staging of glottic tumors. Laryngoscope, 130:1932–1940, 2020

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“…As there are no generally accepted standards for measuring study quality, this form was derived and adapted from the work of de Graeff and Huang et al…”

Section: Methodsmentioning

confidence: 99%

The prognostic value of anterior commissure involvement in T1 glottic cancer: A systematic review and meta‐analysis

Tulli

Bondi

et al. 2019

The Laryngoscope

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“…OSCC metastasis is a complicated process that involves isolation of cells from tumor tissue, regulation of cell activity, invasion, proliferation and evasion through the lymphatic system or blood vessels [7]. In recent years, many studies reported that epithelial-to-mesenchymal transition (EMT) promotes epithelial-like tumor cells to acquire invasive potential, facilitates the transport of these cells through the blood or the lymphatic system [8].…”

Section: Ivyspringmentioning

confidence: 99%

ALDH3A1 acts as a prognostic biomarker and inhibits the epithelial mesenchymal transition of oral squamous cell carcinoma through IL-6/STAT3 signaling pathway

Yang

et al. 2020

J. Cancer

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Objectives: Aldehyde dehydrogenase 3A1 (ALDH3A1) is a member of the ALDH superfamily and its relationship with oral squamous cell carcinoma (OSCC) still unknown. In our subject, we aimed to reveal the expression pattern and clinical value of ALDH3A1 in OSCC and its biological function in OSCC cell lines. Materials and methods: The expression level of ALDH3A1 in paired OSCC tissues and adjacent noncancerous tissues were detected by quantitative real-time PCR, Western blot and immunohistochemistry. The relationship between ALDH3A1 expression and clinical characteristics was analyzed. Besides, cell-counting kit 8, colony formation, wound healing, transwell invasion, apoptosis and cell cycle assays were employed to assess the role of ALDH3A1 in OSCC cells. To explore the influence of ALDH3A1 on OSCC epithelial-to-mesenchymal transition (EMT), the expression of EMT markers (E-cadherin, vimentin, snail, MMP3) on OSCC cells were detected, and possible mechanisms were analyzed. Results: In OSCC tissues, ALDH3A1 was significantly decreased compared to the adjacent normal tissues. Lower ALDH3A1 expression in OSCC tissues was associated with a higher incidence of lymph node metastasis (LNM). Moreover, the overall survival of OSCC with low ALDH3A1 expression was significantly worse compared to that of OSCC with high ALDH3A1 expression. Restored expression of ALDH3A1 suppressed cell proliferation, migration and invasion in OSCC cells. Further experiments showed that ALDH3A1 might inhibit EMT in OSCC via a regulation of the IL-6/STAT3 signal pathway. Conclusion: These data indicate that ALDH3A1 may serve as a biomarker and may be developed into a novel treatment for OSCC.

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“…At present, the pathogenesis of OSCC is still not very clear, which may involve a multi-gene epigenetic and metabolic process, such as the loss of the function of cancer suppressor gene and activation of function of oncogene. [24,25]. Thus, the research on the molecular biological mechanism of OSCC, especially the detection and diagnosis of speci c early tumor markers, which is important for early diagnosis and improvement of prognosis of OSCC patients.…”

Section: Discussionmentioning

confidence: 99%

LncRNA HOXA-AS3 promotes the progression of oral squamous cell carcinoma through sponging miR-218-5p

Zhao

Yao

2020

Preprint

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Objective The aim of the present study was to investigate the roles and molecular mechanism of long non-coding RNA (lncRNA) HOXA-AS3 in the progression of oral squamous cell carcinoma (OSCC). Methods The expression of HOXA-AS3 and miR-218-5p was detected in OSCC tissues and cells using quantitative real-time polymerase chain reaction (qRT-PCR). Cell Counting Kit-8 (CCK-8) and colony formation assays were used to examine the effects of HOXA-AS3 and miR-218-5p on the proliferation of OSCC cells. Luciferase reporter gene assay was used to confirm the directly binding condition between lncRNA HOXA-AS3 and miR-218-5p in OSCC cells. RNA immunoprecipitation assay was employed to verify the interaction between HOXA-AS3 and miR-218-5p. Results The relative expression of lncRNA HOXA-AS3 was observably upregulated in OSCC tissues and cell lines compared with the para-cancerous tissues and normal human oral keratinocyte (NHOK), respectively. Knockdown of HOXA-AS3 significantly inhibited the proliferation and colony formation of OSCC cells. Bioinformatics analysis and luciferase reporter assay showed that HOXA-AS3 directly bound to miR-218-5p. Moreover, the expression of miR-218-5p was negatively regulated by HOXA-AS3, and there was an inverse correlation between them. Silencing miR-218-5p reversed the inhibitory effect of lncRNA HOXA-AS3 knockdown on the proliferative potential of OSCC cells. Conclusion In summary, our study illustrated lncRNA HOXA-AS3 promoted cancer cell proliferation in OSCC possibly by sponging miR-218-5p for the first time, which provides a new target or a potential diagnostic biomarker of the treatment for OSCC.

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Lymph node ratio as prognostic variable in oral squamous cell carcinomas: Systematic review and meta-analysis

Cited by 65 publications

References 77 publications

The prognostic value of anterior commissure involvement in T1 glottic cancer: A systematic review and meta‐analysis

The prognostic value of anterior commissure involvement in T1 glottic cancer: A systematic review and meta‐analysis

ALDH3A1 acts as a prognostic biomarker and inhibits the epithelial mesenchymal transition of oral squamous cell carcinoma through IL-6/STAT3 signaling pathway

LncRNA HOXA-AS3 promotes the progression of oral squamous cell carcinoma through sponging miR-218-5p

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