“…In the work of Kitasaka [10] a 3D minimum directional filter is employed for enhancing blob structures, and then a region growing algorithm is applied in order to cover whole lymph nodes, since detected regions are just the center of the detected structures. Some other researches have proposed the application of prior information on the shape of the lymph nodes: while Slabaugh and Unal propose a graph cut approach and the use of an elliptical shape prior to constrain the segmentation [18] or in an other work, after the definition of spatial and intensity constraints, they estimate the initial contour and approximate and propagate it as an ellipse toward the lymph node boundaries [21], Maleike et al [14] have developed an algorithm based on a deformable surface search, which uses statistical shape models to restrict free deformation, and have constructed an ellipsoid shape model, which strives for a surface with strong gradients and userdefined gray values. Other proposed approaches consist in the application of active contours [7,23] or in the concurrent use of different information such as the grey value range, directed contour information as well as shape knowledge [4] or in the development of atlas-based delineation algorithms [3].…”