Lymph node size as a simple prognostic factor in node negative colon cancer and an alternative thesis to stage migration

Märkl, Bruno; Schaller, Tina; Kokot, Yuriy; Endhardt, Katharina; Kretsinger, Hallie; Hirschbühl, Klaus; Aumann, G; Schenkirsch, Gerhard

doi:10.1016/j.amjsurg.2015.05.026

Cited by 30 publications

(41 citation statements)

References 28 publications

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“…The first indications in this direction came from a previous study, in which we investigated a collection of cases with conventional lymph node dissection [16]. In this study, we could confirm the proposed prognostic effect.…”

Section: Introductionsupporting

confidence: 83%

“…We addressed this issue in a recently published study [16] and were able to show such an effect in colon cancer cases withconventional lymphnode dissectiontechnique.InpT3/ 4 stages, a significant outcome difference was found among the subgroups with high, low, and very low numbers of lymph node diameters <5 mm [16]. Okada et al report similar results when investigating conventionally dissected colon cancer cases [32].…”

Section: Discussionmentioning

confidence: 96%

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Lymph node hypoplasia is associated with adverse outcomes in node-negative colon cancer using advanced lymph node dissection methods

Mayr

Aumann

Schaller

et al. 2016

Langenbecks Arch Surg

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Section: Introductionsupporting

confidence: 83%

Section: Discussionmentioning

confidence: 96%

Lymph node hypoplasia is associated with adverse outcomes in node-negative colon cancer using advanced lymph node dissection methods

Mayr

Aumann

Schaller

et al. 2016

Langenbecks Arch Surg

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“…Criteria for exclusion were neoadjuvant therapy, emergency operation due to obstruction, bleeding or perforation. These cases are part of a previously performed study 9. The follow-up data including the information about the causes of deaths were provided by the clinical and population-based cancer registry of Augsburg.…”

Section: Methodsmentioning

confidence: 99%

The role of lymph node size and FOXP3+ regulatory T cells in node-negative colon cancer

et al. 2016

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Recently, we demonstrated that the intratumoural density of CD3+ and CD8+ T cells is independently prognostic and associated with lymph node (LN) harvest and LN size in node-negative colon cancer. We assumed that FOXP3+ T cells (Tregs) could be inversely associated with these LN features. Therefore, we performed a retrospective immunohistochemical analysis using an already well-characterised collection of stage I/II colon cancer cases. Receiver operating characteristic analysis revealed the optimal cut-off for predicting cancer-related death to be 70 FOXP3+ Tregs/mm at the invasion front. Other than T-stage, none of the relevant histopathological parameters were associated with the density of FOXP3+ cells. In particular, no relation to LN size and count were found. Cancer-specific survival was significantly improved in cases with high densities (115 vs 86 months; p=0.026) in univariable but not in multivariable analysis. In contrast to other cancers, FOXP3+ T cells are associated with a favourable outcome.

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“…Lymph node involvement is one of the most significant However, recent studies have discussed the role of total numbers of lymph nodes retrieved, lymph node ratio, size and immune activation of lymph nodes 18,19 .…”

Section: Discussionmentioning

confidence: 99%

Comparative evaluation of oncologic outcomes in colon cancer

et al. 2016

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PURPOSE:In this paper we report clinical variables on colon cancer series. Oncological outcomes were compared to low-income and high-income countries. METHODS:We analysed a prospective database of 51 colon cancer patients submitted to primary tumor resection between 2010 and 2011, showing clinical variables and oncologic outcomes.RESULTS: R0 resection obtained in 80.4%, 21.6% of patients was TNM stage IV, and only 13.7% showed TNM stage I. Diseasefree survival was 32 months, overall survival was 46 months, and the tumoral recurrence rate was 9.8%. Univariate analysis showed association of serum CEA levels ≥ 5 ng/dl (p= 0.004), presence of metastasis at diagnosis (p= 0.012), compromised surgical margins (p < 0.001) and poorer tumor differentiation (p= 0.041) to death. Multivariate analysis identified compromised surgical margins as an independent risk factor for death due to colon cancer (P=0.003; odds ratio=0.36; 95% confidence interval=0.004-0.33). Nowadays, 62.7% of patients are alive. CONCLUSION:Recurrence rate, disease-free survival and overall survival was similar to those observed in more developed countries.Serum CEA levels ≥ 5 ng/dl, the presence of metastasis at diagnosis, compromised surgical margins and poorer tumor differentiation were associated with death. A compromised surgical margin was the only independent risk factor for death.

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Lymph node size as a simple prognostic factor in node negative colon cancer and an alternative thesis to stage migration

Cited by 30 publications

References 28 publications

Lymph node hypoplasia is associated with adverse outcomes in node-negative colon cancer using advanced lymph node dissection methods

Lymph node hypoplasia is associated with adverse outcomes in node-negative colon cancer using advanced lymph node dissection methods

The role of lymph node size and FOXP3+ regulatory T cells in node-negative colon cancer

Comparative evaluation of oncologic outcomes in colon cancer

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