Lymph node yield and lymph node density for elective level II–IV neck dissections in laryngeal squamous cell carcinoma patients

Çayönü, Melih; Tuna, Evrim Unsal; Acar, Aydın; Dinç, Ayşe Seçil Kayalı; Şahin, Muammer Melih; Boynueğri, Süleyman; Eryılmaz, Adil

doi:10.1007/s00405-019-05560-z

Cited by 11 publications

(11 citation statements)

References 34 publications

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“…As for LHSCC, extracapsular spread (ECS) [35], number of positive lymph nodes [12,13,32], and lymph node yield [18,36,37] were reported. In recent years, several studies suggested that LNR or LND was an independent risk factor for patients with head and neck cancers [4,33,[37][38][39], including LHSCC [13-16, 18, 19, 21, 22], while some other studies found no significant relationship between survival and the LNR or LND for LHSCC [12,40]. As a result, there is no consensus on whether LNR as a significant prognostic factor complements the TNM staging system.…”

Section: Discussionmentioning

confidence: 99%

Prognostic value of lymph node ratio in laryngeal and hypopharyngeal squamous cell carcinoma: A systematic review and meta-analysis

Arikin

Zhang

et al. 2020

Journal of Otolaryngology - Head & Neck Surgery

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Background: Several recent studies have indicated that the lymph node ratio (LNR) is an independent prognostic factor for laryngeal and hypopharyngeal squamous cell carcinoma (LHSCC). The purpose of this paper is to assess the prognostic value of LNR and explore appropriate cutoff values by conducting a systematic review and metaanalysis. Methods: Pubmed, Embase (via Ovid), and Cochrane library were systematically searched for studies on the prognostic value of LNR in LHSCC up to October 31, 2019. Then, Literature review, data extraction, and quality assessment of eligible studies were performed by two independent reviewers back-to-back. Lastly, Stata 14.0 software was hired to conduct a meta-analysis. Results: A total of 445 articles were retrieved, and 13 studies published in English between 2013 and 2019 were included after the title/abstract and full-text screening. Among the 13 studies contributed to 4197 patients, seven studies were about hypopharyngeal squamous cell carcinoma (HPSCC), four studies about laryngeal squamous cell carcinoma (LSCC), and the remaining two studies about LHSCC. The meta-analysis results showed that shorter overall survival (OS) (HR 1.49; 95%CI: 1.18 to 1.88), disease-specific survival (DSS) (HR 1.66; 95%CI: 1.32 to 2.07) and disease-free survival (DFS) (HR 2.04; 95%CI: 1.54 to 2.71) were significantly correlated with a higher LNR in a random-effect model. The cutoff values of eligible studies were varied from 0.03 to 0.14, and the lowest significant LNR was 0.044. Conclusion: LNR is a valuable prognostic factor in the survival of LHSCC and may be used to improve the tumor staging systems, which, however, requires the solid support of more high-quality studies.

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Section: Discussionmentioning

confidence: 99%

Prognostic value of lymph node ratio in laryngeal and hypopharyngeal squamous cell carcinoma: A systematic review and meta-analysis

Arikin

Zhang

et al. 2020

Journal of Otolaryngology - Head & Neck Surgery

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“…[31,32] LNR ratio is increasingly being experimented in thyroid cancers, colon and gastric cancers and other kinds of malignancy, showing a promising prognostic value. [15,[33][34][35] Recent studies indicate the accuracy of LNR in staging is superior than the total amount of the dissected lymph nodes. [36,37] When divided into the groups with regards to the duration of life using the cutoff values of LNR, the lower LNR indicated a longer duration of life.…”

Section: Discussionmentioning

confidence: 99%

Positive lymph node ratio as a prognostic factor for gastric cancer patients: Is it going to supersede positive lymph node number in guidelines?

et al. 2023

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Gastric malignancies constitute the sixth most common cancer with regards to incidence and have the fifth most mortality rates. Extended lymph-node dissection is the surgical modality of choice while treating advanced stage gastric cancer. It is yet a topic of debate, whether or not the amount of positive lymph nodes after a pathological examination following the surgical intervention is of prognostic value. In this study, it is aimed to evaluate the prognostic significance of positive lymph nodes following the surgery. A total of 193 patients who underwent curative gastrectomy between January 2011 and December 2015 have been considered for a retrospective data collection. The cases with R1-R2 resections, palliative or emergent surgeries are excluded. Metastatic to total number of lymph nodes, corresponded a ratio which was analyzed in this survey and practiced as a predictive parameter of disease outcome. This survey includes 138 male (71.5%) and 55 female (28.5%) patients treated between 2011 and 2015 in our clinic. The survey follow-up duration of the cases range between 0, 2, and 72 months, corresponding an average of 23.24 ± 16.99 months. We calculated cutoff value of 0.09 with, sensitivity is 76.32% for positive to total number of lymph nodes ratio, whereas specivity applies for 64.10%, positive predictive value for 58% and negative predictive value for 80.6%. Positive lymph node ratio has a prognostic value in terms of predicting the prognosis of the patients with gastric adenocarcinoma following a curative gastrectomy. This might in long term contribute to the prognostic analysis of patients if integrated in the current staging system.

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“…As a common malignant tumor of head and neck, the researches on LSCC have obtained remarkable achievements, covering laboratory and clinical researches [6,7,29,30]. However, the pathogenesis of LSCC has not been well elucidated.…”

Section: Discussionmentioning

confidence: 99%

Screening of hub-genes, key pathways, and targeted medications in laryngeal squamous cell carcinoma using bioinformatics analysis

Liu¹,

Zhao²

2021

Open J Clin Med Images

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Lymph node yield and lymph node density for elective level II–IV neck dissections in laryngeal squamous cell carcinoma patients

Cited by 11 publications

References 34 publications

Prognostic value of lymph node ratio in laryngeal and hypopharyngeal squamous cell carcinoma: A systematic review and meta-analysis

Prognostic value of lymph node ratio in laryngeal and hypopharyngeal squamous cell carcinoma: A systematic review and meta-analysis

Positive lymph node ratio as a prognostic factor for gastric cancer patients: Is it going to supersede positive lymph node number in guidelines?

Screening of hub-genes, key pathways, and targeted medications in laryngeal squamous cell carcinoma using bioinformatics analysis

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