Lymph Nodes in Leishmaniasis

Angevine, D. Murray; Hamilton, Thais Rose dos Santos; Wallace, F. G.; Hazard, John B.

doi:10.1097/00000441-194507000-00004

Cited by 20 publications

(10 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In agreement with previous reports by Schultz and Swift (6), by Angevine (7), and by Freund and Opie (21) we were unable to find any relationship between skin reactions and titre of circulating antibodies. Likewise, there was no definite correlation between cutaneous reactions and antibody titre of extracts from internal organs.…”

Section: R]~sume and Discussionsupporting

confidence: 93%

Reactions in Skin and in Internal Organs of Rabbits Sensitized With Streptococcus or With Pneumococcus Vaccine and Their Relationship to Antibodies

deGara

Angevine

1943

Journal of Experimental Medicine

View full text Add to dashboard Cite

1. Homologous vaccine was injected into abdominal organs of rabbits after different intervals following sensitization by a single or by repeated intracutaneous injections of heat-killed pneumococci Type I or of formalin-killed hemolytic streptococci (Strain AB13). 2. Local inflammation with or without necrosis was observed in the liver and in the spleen of most of the rabbits. Injections into the kidney and into the anterior wall of the stomach usually caused hemorrhagic lesions at the site of injections, frequently accompanied by slight or moderate inflammation and seldom by necrosis. 3. No correlation was found between the skin and the organ reactions of the animals sensitized with killed streptococci or with killed pneumococci. There was also no correlation between skin or organ reactions and antibody titre of serum. 4. Allergic reactions occur in those organs, namely, liver and spleen, in which antibodies are demonstrable in a high titre, and they are usually absent in kidney and stomach wall in which the antibody titre is low or negative. It is probable that the reactions are caused by the union of antigen and its specific antibody in the tissue.

show abstract

Section: R]~sume and Discussionsupporting

confidence: 93%

Reactions in Skin and in Internal Organs of Rabbits Sensitized With Streptococcus or With Pneumococcus Vaccine and Their Relationship to Antibodies

deGara

Angevine

1943

Journal of Experimental Medicine

View full text Add to dashboard Cite

show abstract

“…In the New World, lymphadenopathy may accompany or even precede skin lesion due to the Leishmania braziliensis complex, indicating that spread from the skin to lymph nodes occurs early in the course of infection [3][4][5]. However, localized lymphadenopathy without cutaneous or systemic manifestations is unusual and has been rarely reported [4][5][6][7][8][9][10][11][12][13][14][15]. Most cases were diagnosed by surgical biopsy because of a suspected lymphoma.…”

Section: Discussionmentioning

confidence: 99%

Localized Lymphadenopathy Due to Leishmanial Infection

et al. 2001

View full text Add to dashboard Cite

A 25-year-old female patient presented with an isolated cervical lymph node enlargement several months after having returned from Spain and Latin America. She had no other signs or symptoms of disease. Leishmania infantum/chagasi was identified as the causative agent. With extended travel activities localized lymph node enlargement due to leishmanial infection should be included in the differential diagnosis of lymphadenopathy of unknown origin.

show abstract

“…Periosteum. The essential lathyric lesions are hyperplasia of periosteal cells, elevation of periosteum, and osteogenesis mainly in membrane but occasionally in cartilage . Angevine (1959) reported absence of ossification, but it has not been possible to confmn this observation.…”

Section: Discussionmentioning

confidence: 99%

Autoradiographic studies in experimental lathyrism

Kennedy

1962

J. Pathol.

View full text Add to dashboard Cite

PLATES XXIX-XXXIII) THE lesions of experimental lathyrism are striking, but it is not known how they are produced. There is evidence that a ground-substance change may be responsible (Menzies and Mills, 1957 ; Ham, 1960) and other observations have suggested an alteration in collagen (Hurley and Ham, 1959 ; Levene and Gross, 1959). In the present work, the specificity of labelling of sulphated mucopolysaccharides in vivo with sulphur-36 given as sulphate (Curran and Kennedy, 1955) has made it possible to determine the distribution of these sulphated compounds by autoradiography, and their relation to lathyric lesions. In a similar way protein metabolism in the lesions has been investigated with sulphur-35 methionine and carbon-14 glycine as precursors. The effect of lathyrogenic agents on the distribution of 36S-sulphate-labelled compounds in healing fractures has also been investigated. The results sustain the hypothesis that the essential change in lathyrism is a failure of formation of chondroitin sulphate A and C complexes with protein, and a subsequent defect in fibrogenesis. MATERIALS AND METHODSA sweet-pea diet, p-amino-propionitrile (BA.E") and amino-acetonitrile ( M ) were used to produce experimental lathyriem in 52 Wistar rats. The animals were 4-7 weeks old a t the beginning of the experiment. Both sexes were used. Cyrrtamine, reported as lathyrogenic (Dasler and Milliser, 1958). was given to 12 weanling rats. Animals suffering from lathyrism are here called lathyric animals.Swest pea (Geiger st al., 1933 ; Ponseti and Baird, 1952). The diet consisted of Lathyma odoratua peas and pellets of standard rat diet crushed together in equal parts by weight. It was given to 11 rats for 3 mth to 1 yr. One of the animals waa given daily subcutaneous injections of BAPN (Wawzonek et al., 1955) so that it received a total of 30 mg. over 15 days, and another received 80 mg. given similarly over 20 days, before injection of isotope.A A N (Wawzonek et al., 1955). This compound waa given daily in 1 6 2 0 mg. doses in water, orally or subcutaneously, to 41 rats. T h e total dose per animal ranged from 60 to 550 mg. Five of these animals received daily 1 mg. deoxycorticosterone acetate (DOCA) subcutaneously (Selye and Bois, 1957). The total dose of DOCA per animal ranged from 15 to 55 mg. and the corresponding AAN range was 250-550 mg. Cyata?nine (Daaler and Milliser, 1958). Cystamine dihydrochloride waa given daily in 10-40 mg. doses in water orally to 12 rats. The total dose per animal ranged from 240 to 1050 mg.

show abstract

Lymph Nodes in Leishmaniasis

Cited by 20 publications

References 0 publications

Reactions in Skin and in Internal Organs of Rabbits Sensitized With Streptococcus or With Pneumococcus Vaccine and Their Relationship to Antibodies

Reactions in Skin and in Internal Organs of Rabbits Sensitized With Streptococcus or With Pneumococcus Vaccine and Their Relationship to Antibodies

Localized Lymphadenopathy Due to Leishmanial Infection

Autoradiographic studies in experimental lathyrism

Contact Info

Product

Resources

About