Lymphadenitis and aortitis due to Brucella melitensis infection

Tosatto, Valentina; Boattini, Matteo; Nascimento, Paula; Moura, Rita Barata

doi:10.1007/s15010-019-01385-4

Cited by 6 publications

(7 citation statements)

References 4 publications

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“…The current case study shows a possible link between brucellosis and various vascular involvement patterns, with brucellar aortitis being the most significant and potentially fatal complication [4][5][6]15]. Arterial as well as major venous thrombotic events can be observed during the brucellosis disease course.…”

Section: N Discussionmentioning

confidence: 69%

“…According to previous research, the aorta appears to be more commonly involved in brucellosis patients [4][5][6]. Of note, contiguous propagation from vertebral involvement (brucellar spondylitis) was suggested as the etiological cause of brucellar aortitis [5].…”

Section: N Discussionmentioning

confidence: 94%

“…After exposure to Brucella, humans generally have a two to four week latency period before exhibiting symptoms, which include acute undulating fever (>90% of all cases), headache, arthralgia (>50%), night sweats, fatigue, and anorexia [3]. Few case reports addressed potential vascular involvement during the disease course of brucellosis [1,[4][5][6][7][8][9][10][11][12][13]. Aortitis is the most commonly reported vascular affection in brucellosis [4][5][6].…”

mentioning

confidence: 99%

“…Few case reports addressed potential vascular involvement during the disease course of brucellosis [1,[4][5][6][7][8][9][10][11][12][13]. Aortitis is the most commonly reported vascular affection in brucellosis [4][5][6]. In brucellosis, different types of vasculitis have been reported infrequently, such as leukocytoclastic vasculitis (LCV), which refers to small blood vessel inflammation, recurrent panniculitis, mixed cryoglobulinemia with renal failure, cutaneous vasculitis and peritonitis, celiac artery (CA) and superior mesenteric artery (SMA) vasculitis, and thrombosis of the inferior vena cava (IVC) [1,[7][8][9][10][11][12].…”

mentioning

confidence: 99%

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Acute brucellosis associated with isolated splenic and left gastric artery vasculitis and acute ischemic bowel infarction. A systematic review of the most recent cases

Saad

Ahmed²,

Alghamdi

et al. 2021

Infez Med

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Brucellosis is a multisystem bacterial zoonosis caused by Gram-negative bacteria Brucella spp. Ingestion of infected food products, direct contact with an infected animal, or inhalation of aerosols are all ways for germs to spread from animals to humans. Intestinal vasculitis with gangrene due to brucellosis has rarely been reported. We report a 62-year-old male patient presenting with acute onset of recurrent attacks of abdominal pain, remittent fever, malaise, and weight loss, which were followed by severe left hypochondrium abdominal pain with rigidity and signs of acute abdomen. Brucellosis was clinically suspected and confirmed by an enzyme-linked immunosorbent assay against the Bru-SUMMARY cella melitensis species. An abdominal CT scan revealed isolated splenic and left gastric artery vasculitis, leading to acute bowel ischemia, bowel infarction and gangrenous jejunal bowel segment. Histopathological examination of the resected gangrenous bowel segment revealed leucocytoclastic vasculitis. The patient was successfully treated with a standardized antimicrobial therapy for brucellosis and a short course of steroids with a complete resolution of the symptoms and signs. The case is discussed and the literature is reviewed.

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Section: N Discussionmentioning

confidence: 69%

Section: N Discussionmentioning

confidence: 94%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Acute brucellosis associated with isolated splenic and left gastric artery vasculitis and acute ischemic bowel infarction. A systematic review of the most recent cases

Saad

Ahmed²,

Alghamdi

et al. 2021

Infez Med

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“…Brucella spp. has also been detected in the Portuguese human population [ 46 , 47 , 48 , 49 ]. A previous study carried out in 332 wild boars reported an apparent seroprevalence of 26.5% in the North region of Portugal [ 32 ].…”

Section: Discussionmentioning

confidence: 99%

Hunting for Answers: Assessing Brucella spp. Seroprevalence and Risks in Red Deer and Wild Boar in Central Portugal

Pires,

Cardoso,

Lopes

et al. 2024

Pathogens

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Between 2016 and 2023, a cross-sectional study was conducted in the central region of Portugal in order to better understand the epidemiology and public health risks resulting from the handling and consumption of game animals infected with Brucella spp. The seroprevalence and risk factors for Brucella spp. seropositivity were evaluated. Antibodies against Brucella spp. were determined using a commercial enzyme-linked immunosorbent assay (ELISA) according to the manufacturer’s instructions. Results showed that in the 650 serum samples collected from red deer (n = 298) and wild boars (n = 352) in Portugal, 21.7% (n = 141; 95% CI: 18.6–25.1%) tested positive. Wild boar had a significantly higher prevalence (35.5%; 95% CI: 30.5–40.8%) than red deer (5.4%, 95% CI: 3.1–8.6%; p ≤ 0.001). Risk factors for seropositivity were investigated using multivariable logistic regression models. The odds of being seropositive was 8.39 (95% CI: 4.75–14.84; p ≤ 0.001) times higher in wild boar than in red deer. Correlations between sex, age, body condition, and seropositivity could not be observed. The higher seroprevalence in wild boar suggests that this species may primarily contribute to the Brucella spp. ecology in central Portugal.

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