Lymphadenoid Goitre and Its Clinical Significance

Williamson, Geo. Scott; Pearse, Innes H.

doi:10.1136/bmj.1.3548.4

Cited by 22 publications

(4 citation statements)

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“…Other theories considered the Hashimoto goiter a premalignant condition (11). Some scholars believed the thyroid itself possessed a lymphogenic secretory capability that became hyperactive in these patients (12). Others viewed the goiter as secondary to constant anxiety and emotional unrest (13).…”

Section: Introductionmentioning

confidence: 98%

Hashimoto's Thyroiditis: Celebrating the Centennial Through the Lens of the Johns Hopkins Hospital Surgical Pathology Records

Caturegli

Remigis

Chuang

et al. 2013

Thyroid

149

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Hashimoto's thyroiditis is now considered the most prevalent autoimmune disease, as well as the most common endocrine disorder. It was initially described in 1912, but only rarely reported until the early 1950s. To celebrate this centennial, we reviewed the surgical pathology archives of the Johns Hopkins hospital for cases of Hashimoto's thyroiditis, spanning the period from May 1889 to October 2012. Approximately 15,000 thyroidectomies were performed at this hospital over 124 years. The first surgical case was reported in 1942, 30 years after the original description. Then, 867 cases of Hashimoto's thyroiditis were seen from 1942 to 2012, representing 6% of all thyroidectomies. Hashimoto's thyroiditis was the sole pathological finding in 462 cases; it accompanied other thyroid pathologies in the remaining 405 cases. The most commonly associated pathology was papillary thyroid cancer, an association that increased significantly during the last two decades. The most common indication for thyroidectomy was a thyroid nodule that was cytologically suspicious for malignancy. Hashimoto's thyroiditis remains a widespread, intriguing, and multifaceted disease of unknown etiology one century after its description. Advances in the understanding of its pathogenesis and preoperative diagnosis will improve recognition and treatment of this disorder, and may one day lead to its prevention.

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Section: Introductionmentioning

confidence: 98%

Hashimoto's Thyroiditis: Celebrating the Centennial Through the Lens of the Johns Hopkins Hospital Surgical Pathology Records

Caturegli

Remigis

Chuang

et al. 2013

Thyroid

149

View full text Add to dashboard Cite

show abstract

“…They found that in some cases, lymphadenoid goitres, the goitre was due to overproduction of secretory lymphocytes. 10 This seems to have corresponded to Riedel's thyroiditis, which is due to hypersecretion by IgG4-secreting plasma cells and is accompanied by fibrosis and atrophy.…”

Section: The Pioneer Health Centrementioning

confidence: 97%

“…The occurrence of a lymphogenic secretion led them to review about 4000 cases of goitre, looking for a form of pathology that would correspond to oversecretion. They found that in some cases, lymphadenoid goitres, the goitre was due to overproduction of secretory lymphocytes 10. This seems to have corresponded to Riedel’s thyroiditis, which is due to hypersecretion by IgG4-secreting plasma cells and is accompanied by fibrosis and atrophy.…”

Section: The Pioneer Health Centrementioning

confidence: 99%

When I use a word . . . Medical blue plaques—the Peckham Experiment

Aronson

2024

BMJ

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The Pioneer Health Centre in Peckham, also known as the Peckham Centre, running what became known at the Peckham Experiment, was founded in 1926 by two doctors, Innes Pearse (1889–1978) and her colleague George Scott Williamson (1884–1953). It closed down in 1929 and reopened in 1935 in new purpose-built premises. Families paid a shilling a week for membership, which gave them free medical consultations of various sorts and access to a wide variety of recreations, but no medical treatment. The purpose was to observe how their health progressed and to discover what factors were involved in good health and wellbeing. After closing down again during World War II the centre reopened, but was forced to close again in 1950, this time for good, because of lack of funds, due to a complex range of factors. In a 1938 publication, the founders stressed that health and wellbeing were not synonymous; health, they wrote, operates with a cumulative deposit account and wellbeing on a diminishing current account. Two blue plaques commemorate the Pioneer Health Centre: an English Heritage blue plaque at 142 Queen’s Road, Peckham, London SE15, the site of the centre’s original building, and a plaque put up by the London Borough of Southwark at the site of the second building, now converted to a block of flats, and situated round the corner from the Queen’s Road premises, in Frobisher Place, St Mary’s Road, Peckham.

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“…In regard to nutrition, their holistic approach to health led them to believe that the crucial element was the degree to which the body was incapable of utilizing food, not the provision of food per se. They found support for their views and for their advocacy of a whole food diet in the work of Sir Robert McCarrison (1944), with whom Williamson cooperated on thyroid research (Williamson, Pearse, and McCarrison 1929). But the concept of health foods was by no means respectable in the 1930s and neither Williamson nor Pearse had McCarrison's reputation in the field, which he had gained as Director of Research in Nutrition in India.…”

Section: The Failure Of the Peckham Ideamentioning

confidence: 99%

A Reassessment of the Work of the Peckham Health Centre, 1926-1951

Lewis¹,

Brookes²

1983

The Milbank Memorial Fund Quarterly. Health and Society

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, a pathologist, and Innes Pearse, a general practitioner, who met while working at the London Hospital during World War I. Williamson and Pearse set up the Centre in the South London suburb of Peckham-hence, its more common designation as the Peckham Centre-as an independent research experiment to test their ideas regarding the nature of health and the conditions necessary for its maintenance. The Centre was open between 1926 and 19 3 0 , 19 35 and 1939 (in new premises built for the purpose), and 1945 and 1950. It functioned as a family club with two conditions for membership: each family paid a weekly subscription, and all family members subjected themselves to periodic "health over hauls." The Centre provided a broad range of services for the whole family: creche facilities; fresh produce for sale from a farm in Kent which was a part of the enterprise; and, towards the end of the experiment, an elementary school for the children. It was this com bination of activities, together with Williamson and Pearse's tireless propaganda efforts, that attracted attention to the Centre. The Centre worked at a number of different levels. To the ex members we interviewed, it combined a good primary health care

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Lymphadenoid Goitre and Its Clinical Significance

Cited by 22 publications

References 0 publications

Hashimoto's Thyroiditis: Celebrating the Centennial Through the Lens of the Johns Hopkins Hospital Surgical Pathology Records

Hashimoto's Thyroiditis: Celebrating the Centennial Through the Lens of the Johns Hopkins Hospital Surgical Pathology Records

When I use a word . . . Medical blue plaques—the Peckham Experiment

A Reassessment of the Work of the Peckham Health Centre, 1926-1951

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