Lymphadenopathic kaposi sarcoma in an immunocompetent young patient: a case report

Kaposi’s Sarcoma with Primary Lymph Node Involvement in a Retroviral Infected (RVI) Patient

“…The growth rate of the mixed cell is in the middle. 23 Our case's histologic findings are consistent with the spindle cell variant. Early lesions are typically identified by an increase in tiny veins and capillaries surrounding one or more dilated vessels.…”

“…KS does occur in women, it progresses more aggressively than in men, despite the fact that female-to-male ratios in women range from 1: 3-15. [21][22][23] KS is categorised into four distinct forms: iatrogenic disease, which impacts individuals who have received organ transplants and are undergoing immunosuppressive therapy; epidemic disease, which is the most prevalent opportunistic cancer in people infected with HIV-1; and the classical variant, which mainly affects older men of Jewish and East European ancestry. Conversely, the African endemic variant mainly affects children, teens, and adults in sub-Saharan Africa and has many extracutaneous manifestations.…”

“…Conversely, the African endemic variant mainly affects children, teens, and adults in sub-Saharan Africa and has many extracutaneous manifestations. 1,[23][24][25][26][27] Patients who have a high viral load count of more than 10,000 copies/mL and a low CD4 count, especially fewer than 100 cells/mm3, are susceptible to KS. [3][4][5][6] But our patient had a CD4+ count of 378 mm3, and the viral load was undetectable, which makes our case more atypical.…”

“…28 HHV-8, which infects KS spindle cells, is linked to KS. 8,23,29 HHV8 infection is not ubiquitous. Although it affects less than 5% of the general population in the USA and Europe, men who have sex with men (MSM) and certain regions of the world, like sub-Saharan Africa and the countries bordering the Mediterranean, have much higher prevalence rates of it.…”

“…The most effective treatment for KS patients has not yet been determined, however recent advancements in comprehending the disease process may produce a universally accepted procedure. 1,23 Our patient was started on paclitaxel (175mg daily) and dexamethasone (8mg daily) because she was diagnosed with one of the aggressive forms of Kaposi sarcoma which is epidemic type KS and she was symptomatic.…”