Lymphangiosarcoma in a Dog Treated with wurgery and Chemotherapy

Itoh, Teruo; Mikawa, Kazuhiro; Mikawa, Mayumi; Nibe, Kazumi; Uchida, Kazuyuki

doi:10.1292/jvms.66.197

Cited by 18 publications

(51 citation statements)

References 8 publications

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“…When surgical excision is not reasonable or if residual tumour remains, radiation therapy can be effective for local control. Because of the aggressive metastatic behaviour, local treatment combined with doxorubicin‐based chemotherapy is recommended for best tumour control . Conversely, cutaneous hemangiosarcoma is associated with a good prognosis following tumour removal without the need for adjuvant chemotherapy .…”

Section: Discussionmentioning

confidence: 99%

The use of novel lymphatic endothelial cell‐specific immunohistochemical markers to differentiate cutaneous angiosarcomas in dogs

Halsey

Worley

Curran

et al. 2014

Vet Comparative Oncology

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Lymphangiosarcomas are uncommon vascular neoplasms that arise from lymphatic endothelial cells (LECs). They efface and replace normal subcutaneous tissue and are characterised by arborising, vascular channels lined by a single layer of pleomorphic endothelial cells and a paucity of erythrocytes. Lymphangiosarcomas are architecturally similar to hemangiosarcomas, a common malignancy of vascular origin arising from blood vascular endothelial cells. Common immunohistochemical markers for vascular endothelium, such as Factor VIII-related antigen (F8RA) and CD31, have traditionally been used to confirm the diagnosis of tumours of vascular origin. However, these markers fail to differentiate between lymphangiosarcoma and hemangiosarcoma, which often show overlapping morphologic features, disparate clinical behaviour and require different treatment modalities. Here we describe the use of two novel LEC-specific markers, lymphatic vessel endothelial receptor-1 (LYVE-1) and prospero-related homeobox gene-1 (PROX-1), to further differentiate between vascular tumours of lymphatic (lymphangiosarcoma) and blood (hemangiosarcoma) endothelial cell origin in the dog.

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Section: Discussionmentioning

confidence: 99%

The use of novel lymphatic endothelial cell‐specific immunohistochemical markers to differentiate cutaneous angiosarcomas in dogs

Halsey

Worley

Curran

et al. 2014

Vet Comparative Oncology

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“…It was first documented in a dog in 1981 . To date, 18 dogs have been reported in the literature with LAS ranging in age from 8 weeks to 13 years . Lymphangiosarcoma commonly presents in dogs as a subcutaneous mass or focal swelling.…”

Section: Introductionmentioning

confidence: 99%

“…Lesions have been reported in the cervical region and thoracic inlet, inguinal region, hind limb, axillary region and forelimb, thoracic cavity and mediastinum, thoracic subcutis, and retroperitoneal space with vaginal prolapse . Most reported cases occurred in large breed dogs including a Giant Schnauzer, Standard Poodle, Bouvier des Flandres, Golden Retriever, Doberman Pinscher, pointer, Chow Chow, Bullmastiff, Siberian husky, Boxer, and Chesapeake Bay retriever, and one occurred in a Toy Poodle . Most cases had a short clinical course once a diagnosis was made, and commonly had evidence of metastasis at the time of diagnosis …”

Section: Introductionmentioning

confidence: 99%

Lymphangiosarcoma in 12 dogs: a case series (1998–2013)

Curran

Halsey

Worley

2014

Vet Comparative Oncology

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Lymphangiosarcoma (LAS) is an uncommon malignant neoplasia arising from lymphatic endothelium; little information exists regarding therapy. Single institutional retrospective review for canine LAS histopathology diagnoses over a 15-year period yielded 12 dogs. Ten dogs were presented for a mass and/or swelling at cervical, trunk or limb regions. Prior to diagnosis, 10 dogs received empiric wound therapy. Cytology performed in 10 consisted of mild inflammation. Survival ranged from 60, 168 and 876 days for three dogs with palliation; 90 days with prednisone in one; 182 days with chemotherapy in one; 240, 267, 487, 630 and 941 days for five receiving surgery; and 574 days for one receiving surgery, radiation and chemotherapy. One dog is alive with recurrence at 243 days following surgery and carboplatin chemotherapy. Clinical improvement existed in LAS dogs receiving multimodal therapies. Early tissue biopsies are recommended for progressive oedematous lesions of unknown origin.

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“…Lymphangiosarcoma is an extremely rare, generally aggressive malignant tumour which has been reported in humans 3,5,19,26 , only 16 dogs 1,4,8,9,[14][15][16][17][18]20,22,24,27,29 , a similar number of cats 19,11,12,25,28 , 2 horses 13,23 , and a cow 21 . Lymphangiosarcoma in dogs, with comparison with that in humans, is reviewed in a companion article 30 .…”

Section: Introductionmentioning

confidence: 99%

Lymphangiosarcoma in a 3.5-year-old Bullmastiff bitch with vaginal prolapse, primary lymph node fibrosis and other congenital defects : clinical communication

Williams¹,

Birrell²,

Wilpe³

2005

J. S. Afr. Vet. Assoc.

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Lymphangiosarcoma is an extremely rare tumour in dogs with only 16 cases reported in the literature. Lymphoedema, whichmaybe primary due to defects in the lymphatic system, or secondary to various other pathologies, often precedes malignancy. Of the 16 canine reports, only 1 dog was confirmed as having had prior primary lymphoedema due to aplasia of the popliteal lymph nodes. A case of lymphangiosarcoma is described in a 3.5-year-old purebred, Bullmastiff bitch which presented with vaginal blood 'spotting' for 3 weeks after cessation of oestrus, during which intromission by the male had been unsuccessful. During ovariohysterectomy a large multicystic, proliferative, spongy, fluid-filled, brownish-red mass surrounding the cervix and projecting into the abdominal space was removed with the cervix, and a diagnosis of lymphangiosarcoma made on histological and electron microscopic examination of the tissue. Ultrastructurally, no basement membrane or pericytes were found, only some of the neoplastic endothelial cells were linked by tight junctions while there were gaps between others, and neither micropinocytotic vesicles nor Weibel-Palade bodies occurred in the cells examined.Very few of the endothelial cells lining the many interlinking, tortuous maze of channels, stained slightly positive immunohistochemically for factor VIII-related antigen. The channels were filled mostly with serous fluid, and occasionally mixed leucocytes and some erythrocytes. The endothelium was often associated with underlying blocks of collagenous material, as well as looselyarranged aggregates of lymphocytes, other mononuclear cells and occasional neutrophils in the connective tissue septae and more prominently perivascularly. The bitch was discharged on antibiotic treatment but returned 2 weeks later with apparent prolapsed vagina which failed to reduce over the next week. Laparotomy revealed the tumour to have spread extensively in the caudal abdomen to involve the broad ligament and the ventral rectal serosa, and the 'prolapsed' tissue was found to be expanded vaginal wall. The bitch was euthanased and necropsied, Histological examination confirmed lymphangiosarcomatous invasion of the submucosal and muscular layers of the retroperitoneal, traumatised, prolapsed part of the vagina, the urethra and the ventral rectal wall. The broad ligament was diffusely invaded with tumour which had proliferated into the caudal abdominal space, and 3 small intra-trabecular foci of tumour were found in the right popliteal lymph node near the hilus. Mitotic figures were generally scarce. There was mild subcutaneous oedema of the ventral trunk extending from the axillae to the inner proximal thighs, which had not been evident clinically, and the lymph nodes (peripheral more so than internal) microscopically showed marked trabecular and perivascular fibrosis especially in hilar regions. Other congenital defects were hepatic capsular and central venous fibrosis with lymphatic duplication and dilatation in all areas of connective tissue, ventrally-incongruou...

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Lymphangiosarcoma in a Dog Treated with wurgery and Chemotherapy

Cited by 18 publications

References 8 publications

The use of novel lymphatic endothelial cell‐specific immunohistochemical markers to differentiate cutaneous angiosarcomas in dogs

The use of novel lymphatic endothelial cell‐specific immunohistochemical markers to differentiate cutaneous angiosarcomas in dogs

Lymphangiosarcoma in 12 dogs: a case series (1998–2013)

Lymphangiosarcoma in a 3.5-year-old Bullmastiff bitch with vaginal prolapse, primary lymph node fibrosis and other congenital defects : clinical communication

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