Lymphatic clearance from the blood after subarachnoid hemorrhages

Semyachkina-Glushkovskaya, O.; Abdurashitov, Arkady S.; Dubrovsky, Alexander; Shirokov, Alexander; Navolokin, Nikita; Klimova, Maria; Torres, E. Duarte; Khorovodov, Alexander; Mamedova, Aysel; Shareef, Ali Esmat; Terskov, Andrey; Saranceva, Elena; Iskra, Tatyana; Kurths, Jürgen

doi:10.1117/12.2509065

Cited by 2 publications

(4 citation statements)

References 14 publications

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“…Thus, both human and animal data clearly suggest the lymphatic pathway of RBCs clearance from the brain into dcLNs, which is consistent with the oldest and latest data about lymphatic efflux of RBCs [12, 17, 25, 26].…”

Section: Resultssupporting

confidence: 86%

“…These results provide strong support for the old theory of RBCs evacuation from the brain via lymphatic efflux [12][13][14][15][16][17]. Our data are also consistent with the newest discovery of the meningeal lymphatic pathway of clearance of RCBs from the brain after brain hemorrhage [25,26]. Taking into account all of the above, we hypothesized that the lymphatic mechanisms of blood clearance from the brain can be a new therapeutic target for treatment of IVH.…”

Section: Discussionsupporting

confidence: 90%

“…Quite recently the old concept of lymphatic pathway of RBC move from the brain was supplemented by new knowledge of RBCs clearance via the meningeal lymphatic vessels (MLVs) after ICH that was first proposed by our group in 2019 [25] and afterward it was studied after SAH by Chinese group in 2020 [26]. However, it still remain unanswered, whether RBCs can move from the ventricles into the lymphatic system and if so, whether this process can be therapeutically stimulated.…”

Section: Introductionmentioning

confidence: 99%

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Photostimulation of lymphatic clearance of red blood cells from the mouse brain after intraventricular hemorrhage

Takata

et al. 2020

Preprint

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Intraventricular hemorrhage (IVH) is the most fatal form of brain injury, yet a therapy directed at ameliorating intraventricular clot is very limited. There is accumulating evidence that an augmentation of the meningeal lymphatic (MLVs) functions might be a promising therapeutic target for IVH. In particular, the photostimulation (PS) of MLVs could be promising for non-invasive therapy of IVH via PS of clearance of red blood cells (RBCs) from the brain via MLVs. Indeed, we uncover that PS has therapeutic effects on IVH in mice reducing the mortality, improving the emotional status, accelerating the RBCs evacuation from the ventricles and increasing the ICP recovery. Our findings strongly suggest that the PS-mediated stimulation of drainage and clearing functions of MLVs can be a novel bedside, readily applicable and commercially viable technologies for treatment of IVH. These pilot results open new horizons in a non-invasive therapy of IVH via PS stimulation of regenerative lymphatic mechanisms.

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Section: Resultssupporting

confidence: 86%

Section: Discussionsupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

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Photostimulation of lymphatic clearance of red blood cells from the mouse brain after intraventricular hemorrhage

Takata

et al. 2020

Preprint

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“…Furthermore, the increased diameter of meningeal lymphatic vessels suggests the activation of meningeal lymphatic drainage function after stroke (Semyachkina-Glushkovskaya et al, 2020). Compared with the slow and non-remarkable accumulation of gold nanorods in the deep CLNs of normal mice, the extensive accumulation of gold nanorods in cavities of deep CLNs within three hours after SAH indicated the activation of lymphatic clearance as SAH progressed (Semyachkina-Glushkovskaya et al, 2019). Recent work also demonstrates that the increased outflow rate of meningeal lymphatics participates in the clearance of extravasated erythrocytes from CSF into CLNs after SAH (Chen et al, 2020).…”

Section: Meningeal Lymphatic Involved In Edema Formationmentioning

confidence: 99%

Cerebral Edema Formation After Stroke: Emphasis on Blood–Brain Barrier and the Lymphatic Drainage System of the Brain

Chen

Shao

2021

Front. Cell. Neurosci.

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Brain edema is a severe stroke complication that is associated with prolonged hospitalization and poor outcomes. Swollen tissues in the brain compromise cerebral perfusion and may also result in transtentorial herniation. As a physical and biochemical barrier between the peripheral circulation and the central nervous system (CNS), the blood–brain barrier (BBB) plays a vital role in maintaining the stable microenvironment of the CNS. Under pathological conditions, such as ischemic stroke, the dysfunction of the BBB results in increased paracellular permeability, directly contributing to the extravasation of blood components into the brain and causing cerebral vasogenic edema. Recent studies have led to the discovery of the glymphatic system and meningeal lymphatic vessels, which provide a channel for cerebrospinal fluid (CSF) to enter the brain and drain to nearby lymph nodes and communicate with the peripheral immune system, modulating immune surveillance and brain responses. A deeper understanding of the function of the cerebral lymphatic system calls into question the known mechanisms of cerebral edema after stroke. In this review, we first discuss how BBB disruption after stroke can cause or contribute to cerebral edema from the perspective of molecular and cellular pathophysiology. Finally, we discuss how the cerebral lymphatic system participates in the formation of cerebral edema after stroke and summarize the pathophysiological process of cerebral edema formation after stroke from the two directions of the BBB and cerebral lymphatic system.

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Lymphatic clearance from the blood after subarachnoid hemorrhages

Cited by 2 publications

References 14 publications

Photostimulation of lymphatic clearance of red blood cells from the mouse brain after intraventricular hemorrhage

Photostimulation of lymphatic clearance of red blood cells from the mouse brain after intraventricular hemorrhage

Cerebral Edema Formation After Stroke: Emphasis on Blood–Brain Barrier and the Lymphatic Drainage System of the Brain

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