Lymphatic drainage patterns of oral maxillary tumors: Approachable locations of sentinel lymph nodes mainly at the cervical neck level

Boeve, Koos; Schepman, Kees-Pieter; Vegt, Bert van der; Schuuring, Ed; Roodenburg, Jan; Brouwers, Adrienne H.; Witjes, Max J. H.

doi:10.1002/hed.24628

Cited by 10 publications

(16 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The sentinel lymph node biopsy (SLNB) has been introduced in the last decade as diagnostic technique for the detection of occult metastasis, in order to select patients with early stage OSCC for a neck dissection or a clinical follow‐up strategy 1 . In the Netherlands, patients with a metastasis‐positive sentinel lymph node (SLN) currently receive a modified radical neck dissection (MRND) in a second surgical procedure 6,7 . A meta‐analysis reported a high pooled sensitivity (87%) and negative predictive value (94%) for detecting occult metastasis using the SLNB procedure 8 .…”

Section: Introductionmentioning

confidence: 99%

Cortactin expression assessment improves patient selection for a watchful waiting strategy in pT1cN0‐staged oral squamous cell carcinomas with a tumor infiltration depth below 4 mm

et al. 2021

Self Cite

View full text Add to dashboard Cite

Background In this feasibility study we aimed to evaluate the value of previously reported molecular tumor biomarkers associated with lymph node metastasis in oral squamous cell carcinoma (OSCC) to optimize neck strategy selection criteria. Methods The association between expression of cortactin, cyclin D1, FADD, RAB25, and S100A9 and sentinel lymph node status was evaluated in a series of 87 (cT1‐2N0) patients with OSCC treated with primary resection and SLNB procedure. Results Tumor infiltration depth and tumor pattern of invasion were independent prognostic markers for SLN status, while none of the tumor makers showed a better prognostic value to replace SLNB as neck staging technique in the total cohort. However, in the subgroup of patients with pT1N0 OSCC, cortactin expression (OR 16.0, 95%CI 2.0–127.9) was associated with SLN classification. Conclusions Expression of cortactin is a promising immunohistochemical tumor marker to identify patients at low risk that may not benefit from SLNB or END.

show abstract

Section: Introductionmentioning

confidence: 99%

Cortactin expression assessment improves patient selection for a watchful waiting strategy in pT1cN0‐staged oral squamous cell carcinomas with a tumor infiltration depth below 4 mm

et al. 2021

Self Cite

View full text Add to dashboard Cite

show abstract

“…The SLNB procedure was described in detail before and was mostly the same in both centres . Lymphoscintigraphy and SPECT/CT scans were made 1 day before surgery.…”

Section: Methodsmentioning

confidence: 99%

“…Lymphoscintigraphy and SPECT/CT scans were made 1 day before surgery. Intraoperatively, SLNs were harvested after gamma probe assisted localisation . SLNs were histopathologically examined by SSS with an interval of 500 μm and additional pan‐cytokeratin antibody (AE 1/3) immunohistochemistry staining.…”

Section: Methodsmentioning

confidence: 99%

“…The SLNB procedure was described in detail before and was mostly the same in both centres. 18 Lymphoscintigraphy and SPECT/CT scans were made 1 day before surgery. Intraoperatively, SLNs were harvested after gamma probe assisted localisation.…”

Section: Study Proceduresmentioning

confidence: 99%

“…Intraoperatively, SLNs were harvested after gamma probe assisted localisation. 18 test. Continuous data were tested using the Student's t test or the Mann-Whitney U test for normally or skewed distributed data, respectively.…”

Section: Study Proceduresmentioning

confidence: 99%

See 2 more Smart Citations

High sensitivity and negative predictive value of sentinel lymph node biopsy in a retrospective early stage oral cavity cancer cohort in the Northern Netherlands

Boeve

Schepman

Schuuring³

et al. 2018

Clinical Otolaryngology

View full text Add to dashboard Cite

Objectives: In cT1-2N0, oral squamous cell carcinoma (OSCC) occult metastases are detected in 23%-37% of cases. Sentinel lymph node biopsy (SLNB) was introduced in head and neck cancer as a minimally invasive alternative for an elective neck dissection in neck staging. Meta-analyses of SLNB accuracy show heterogeneity in the existing studies for reference standards, imaging techniques and pathological examination. The aim of this study was to assess the sensitivity and negative predictive value (NPV) of the SLNB in detecting occult metastases in cT1-2N0 OSCC in a well-defined cohort. Results: In all cases, SLNs were harvested. A total of 25 (27%) patients had tumour-positive SLNs. The median follow-up was 32 months (range 2-104). Four patients were diagnosed with an isolated regional recurrence in the SLNB negative neck side resulting in an 85% sensitivity and a 94% NPV. Conclusion:In our cohort, the SLNB detected occult metastases in early OSCC with 85% sensitivity and 94% NPV. This supports that SLNB is a reliable procedure for surgical staging of the neck in case of oral cT1-2N0 SCC.--

show abstract

Occult metastases of oral maxillary squamous cell carcinoma: Systematic review and meta‐analysis

et al. 2022

View full text Add to dashboard Cite

Squamous cell carcinoma (SCC) is the most common malignant neoplasm of the oral cavity. The performance of END (elective neck dissection) in cases of maxillary SCC is controversial because the literature traditionally classified maxillary tumors as having low metastatic potential. The aim of this systematic review and meta‐analysis was to determine the percentage of occult cervical metastases in maxillary SCC to identify in which cases there is the need to perform an END. We searched the PubMed database to select articles dated from 2000 to 2020 that fulfilled our inclusion criteria; finally, we reviewed 27 manuscripts. We show that the overall cervical and occult metastases rate was 35% and 19%, respectively. For T1, the percentage of occult metastasis rate was 11%; for T2, it was 16%; for T3, it was 20%; and for T4, it was 32%. We suggest END (levels I–II–III) as treatment to T3/T4 cN0 patients.

show abstract

Lymphatic drainage patterns of oral maxillary tumors: Approachable locations of sentinel lymph nodes mainly at the cervical neck level

Abstract: This study suggests the likelihood of 73% of exclusively cervical level I to III sentinel lymph nodes in oral maxillary cancer. © 2016 Wiley Periodicals, Inc. Head Neck 39: 486-491, 2017.

Cited by 10 publications

References 24 publications

Cortactin expression assessment improves patient selection for a watchful waiting strategy in pT1cN0‐staged oral squamous cell carcinomas with a tumor infiltration depth below 4 mm

Cortactin expression assessment improves patient selection for a watchful waiting strategy in pT1cN0‐staged oral squamous cell carcinomas with a tumor infiltration depth below 4 mm

High sensitivity and negative predictive value of sentinel lymph node biopsy in a retrospective early stage oral cavity cancer cohort in the Northern Netherlands

Occult metastases of oral maxillary squamous cell carcinoma: Systematic review and meta‐analysis

Contact Info

Product

Resources

About