Lymphatic Leakage after Pelvic Lymphadenectomy for Cervical Cancer: A Retrospective Case-Control Study

Abstract

Background: The study aims to evaluate the clinical features and management of postoperative lymphatic leakage (PLL) in patients with cervical cancer who received pelvic lymphadenectomy. Methods: This retrospective study screened consecutive patients with cervical cancer (stage Ia2-IIb). Results: Among 3427 cases screened, 63 patients (1.8%) were diagnosed with PLL, which manifested as persistent abdominal drainage (42/63, 66.7%), chylous ascites (12/63, 19.0%) or vaginal drainage (9/63, 14.3%). Median time from surgery to onset of PLL was 6 days (range, 4-21 days). All cases resolved in a median 10 days (range, 3-56 days) after conservative treatment; although one case experienced recurrence of vaginal drainage after 26 days, this also resolved after conservative therapy. Multivariate analysis showed that two cycles of neoadjuvant chemotherapy (odds ratio [OR], 3.283; 95% confidence interval [95%CI], 1.289-8.360; P=0.013 ), a decrease in hemoglobin level of ≥20 and <30 g/L (OR, 6.175; 95%CI, 1.033-10.919; P=0.046) or ≥30 g/L (OR, 8.467; 95%CI, 1.248-17.426; P=0.029), and postoperative albumin level ≥30 and <35 g/L (OR, 2.552; 95%CI, 1.112-5.857; P=0.027) or <30 g/L (OR, 5.517; 95%CI, 2.047-18.148; P=0.012) were associated with PLL.Conclusion: Neoadjuvant chemotherapy, postoperative anemia and postoperative hypoproteinemia are risk factors for PLL.