Lymphatic Migration After Laser Surgery

Fruhling, Janos; Lejeune, Ferdinand; Hoof, G. Van; A, Gerard

doi:10.1016/s0140-6736(77)90906-0

Cited by 13 publications

(4 citation statements)

References 2 publications

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“…We previously reported that skin excision with the CO, laser did not stop colloid particles, whose size varied between 0.1 and 0.3 pm, migrating into the lymphatics (8). Although other work using labelled melanoma cells in mice showed that laser surgery did seem to impair the migration of the label (9), we consider that our findings with labelled colloid reduce the advantage of using the laser to excise melanomas.…”

Section: Discussioncontrasting

confidence: 46%

Impairment of skin graft take after CO2 laser surgery in melanoma patients

Lejeune

Hoof

1980

Journal of British Surgery

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Twenty-four patients presenting with primary malignant melanoma of the skin (stage 1) were submitted to wide excision of the tumour, followed by immediate split-skin grafting. In 12 patients a CO2 laser was used to excise the melanoma and only 1 of these patients had a 100 per cent skin graft take, while 9 out of 12 patients whose melanoma was exercised with a conventional scalpel had a 100 per cent take. It is concluded that skin excision with the CO2 laser impairs subsequent skin graft take.

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Section: Discussioncontrasting

confidence: 46%

Impairment of skin graft take after CO2 laser surgery in melanoma patients

Lejeune

Hoof

1980

Journal of British Surgery

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“…Evans blue was not present in the tissue beyond of the CO2-1aser incision [17]. However, Ehrenberger and Innitzer [3], Frtihling et al [6] and Plenk et al [19] found that CO2-1asers cannot occlude lymph vessels.…”

Section: Introductionmentioning

confidence: 99%

Comparative study of conventional scalpel and CO2-laser in experimental tumor surgery

et al. 1986

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The study hereby submitted has been designed to show whether there are any differences between using a conventional knife or a CO2-laser when excising and grafting tumors in animal experiments. The animals were C57B1/6 mice, the tumor was the Lewis lung carcinoma. Eight days after tumor inoculation into the s.c. layer of the back, 213 mice were treated by tumor excision either with a conventional knife or a CO2-laser. Eighty-six excised tumors were cut, and the tumor surface was swabbed into the s.c. layer on the nape of 86 tumor-free mice. Survival times of the laser-operated animals were insignificantly longer. However, small tumors showed markedly longer survival times. The interval without recurrence was longer for all tumor sizes when the laser was used (P less than 0.005). The laser method yielded lower growth rates when the tumor surface was swabbed into tumor-free mice (P less than 0.0001). Histological and cytologic tests of the laser-excised and- swabbed specimen demonstrated a high rate of cell destruction. Therefore, the CO2-laser seems to have some significance in cases where the incision is made close to the tumor or where tumor surfaces may be lesioned.

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“…However, other studies support a contrary thesis that only blood vessel are occluded by the laser while lymphatics remain open [29]. In a small patient group Frü hling et al found no evidence that the CO 2 laser beam obliterates the lymphatic drainage of the surgical wound [30]. Thus, a laser-cut end of a lymphatic could be a gateway for tumor dissemination.…”

Section: Discussionmentioning

confidence: 99%

“…Monopolar coagulation or sutures were necessary in only 9/69 animals. As already discussed, while there is no uniform opinion concerning whether the laser occludes lymphatics, it has been demonstrated, that the laser seals smaller blood vessels [11,[26][27][28][29][30]34]. This effect may have resulted in decreased hematogenous spread in the laser group.…”

Section: Dissemination Through the Peritumoral Lymphaticsmentioning

confidence: 99%