Lymphatic Specification and Development, EMT-MET, and Cancer Spread

Geng, Xin; Srinivasan, Ramesh

doi:10.1007/978-3-030-93084-4_20

Cancer Metastasis Through the Lymphovascular System 2022

DOI: 10.1007/978-3-030-93084-4_20

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Lymphatic Specification and Development, EMT-MET, and Cancer Spread

Xin Geng

Ramesh Srinivasan

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“…Mouse embryonic dermal skin was peeled and immunolabeled as described by Geng and Srinivasan(5).Primary antibodies for immunohistochemistry included rabbit anti-PROX1 (catalog 11-002, Angiobio), rat anti-mouse CD31 (catalog 553370, BD Pharmingen), and goat anti-mouse VEGRF3 (cata-log AF743) from R&D Systems. Secondary antibodies for IHC included Cy3-conjugated donkey anti-rabbit, Cy5-conjugated donkey anti-rat, and Alexa 488-conjugated donkey anti-goat, purchased from Jackson Immuno-Research Laboratories (catalogs 711-165-152, 712-175-150 and 705-545-147 respectively).…”

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confidence: 99%

LACK OF EMBRYONIC HOMOZYGOUS OR ADULT HETEROZYGOUS LYMPHATIC PHENOTYPES FOR A Sos1 MUTATION AND LACK OF LYMPHATIC EMBRYONIC PHENOTYPES FOR A HOMOZYGOUS Cx47 MUTATION IN MICE

et al. 2022

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We have studied the lymphatic phenotypes of 2 mutations, known to cause abnormalities of lymphatics in humans, in mice. The Cx47 R260C mutation (variably penetrant in humans heterozygous for it and causing limb lymphedema) had an adult mouse phenotype of hyperplasia and increased lymph nodes only in homozygous condition but we did not find any anatomical phenotype in day 16.5 homozygous embryos. Mice harboring the Sos1 mutation E846K (causing Noonan's 4 in man which occasionally shows lymphatic dysplasia) had no adult heterozygous phenotype in lymphatic vessel appearance and drainage (homozygotes are early embryonic lethals) while day 16.5 heterozygous embryos also had no detectable anatomical phenotype.

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confidence: 99%

LACK OF EMBRYONIC HOMOZYGOUS OR ADULT HETEROZYGOUS LYMPHATIC PHENOTYPES FOR A Sos1 MUTATION AND LACK OF LYMPHATIC EMBRYONIC PHENOTYPES FOR A HOMOZYGOUS Cx47 MUTATION IN MICE

et al. 2022

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Lymphatic Specification and Development, EMT-MET, and Cancer Spread

Cited by 1 publication

References 62 publications

LACK OF EMBRYONIC HOMOZYGOUS OR ADULT HETEROZYGOUS LYMPHATIC PHENOTYPES FOR A Sos1 MUTATION AND LACK OF LYMPHATIC EMBRYONIC PHENOTYPES FOR A HOMOZYGOUS Cx47 MUTATION IN MICE

LACK OF EMBRYONIC HOMOZYGOUS OR ADULT HETEROZYGOUS LYMPHATIC PHENOTYPES FOR A Sos1 MUTATION AND LACK OF LYMPHATIC EMBRYONIC PHENOTYPES FOR A HOMOZYGOUS Cx47 MUTATION IN MICE

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