Lymphatic spread and its prognostic value in patients with rectal cancer

Hojo, Keiko; Koyama, Yasuo; Moriya, Yoshihiro

doi:10.1016/0002-9610(82)90018-6

Cited by 225 publications

(92 citation statements)

References 25 publications

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“…4 In the TNM classification, a lateral lymph node is defined as nonregional for rectal cancer, and it has been widely accepted since the 1950s that the survival rate of patients with lateral involvement is unfavorable. [5][6][7] The incidence of lateral cancer spread in patients with lower rectal cancer has been reported as 10% to 25%. 6,8 Further, occult metastases are present in approximately 4% of patients who, based on conventional histologic examination, are negative for lateral node involvement.…”

Section: Discussionmentioning

confidence: 99%

Prognostic Determinants of Patients With Lateral Nodal Involvement by Rectal Cancer

Ueno¹,

Mochizuki²,

Hashiguchi³

et al. 2001

Annals of Surgery

112

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ObjectiveTo clarify the characteristics related to long-term survival in patients with lateral nodal involvement. Summary Background DataFew reports have addressed the prognostic determinants in patients with actual lateral nodal involvement, which are important in determining treatment. MethodsReview of a prospective colorectal database at a single institution for a 10-year period (1987)(1988)(1989)(1990)(1991)(1992)(1993)(1994)(1995)(1996) identified 53 patients with lateral nodal involvement. ResultsAll nine patients who underwent resection of synchronous distant metastases developed recurrence and died within 3 years. Of the 44 patients without distant metastases, 25 (57%) developed locoregional recurrence, and the overall 5-year survival rate was 32%. Multivariate analysis showed that age, total number of involved nodes (mesorectal and lateral), and circumferential surgical margin involvement had independently predicted postoperative survival. Patients with three or fewer nodes involved accounted for one third of lateral-positive patients, with a 5-year survival rate of 75%, whereas the 18 patients with four or more involved nodes had a 5-year survival rate of 4%. All eight patients with circumferential margin involvement died of carcinoma, and seven developed locoregional recurrences. Involvement of other pelvic organs had no effect on prognosis, nor were adverse prognostic outcomes noted by the region of lateral involvement.

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Section: Discussionmentioning

confidence: 99%

Prognostic Determinants of Patients With Lateral Nodal Involvement by Rectal Cancer

Ueno¹,

Mochizuki²,

Hashiguchi³

et al. 2001

Annals of Surgery

112

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“…The presence and number of lymph node metastases in rectal cancer patients also correlates with prognosis. Survival rate drops from 50–55% in patients with one to four positive regional nodes to 22–28% in patients with five or more positive perirectal lymph nodes [26]. …”

Section: Pathological Staging and Prognosismentioning

confidence: 99%

Modern Management of Rectal Cancer

Pricolo¹,

Potenti²

2001

Dig Surg

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“…It is a less invasive procedure that, according to its indication criteria, brings benefits in terms of rectal and canal anal functional preservation, morbid-mortality and costs. 1,2 Literature estimates reveal that 40 to 50 % of the primary rectal cancer will be presented without lymphonodal commitment (T1, T2, T3 -No) as soon as diagnosed 26,27 and that 15% of the patients considered cured show tumors limited to the rectal wall (T1 -T3 -No). 28 Every year, more than 7000 patients with rectal cancer are potentially cured by local excision as the only therapeutic method.…”

Section: Discussionmentioning

confidence: 99%

Transanal endoscopic operation: a new proposal

Rocha

Féres

2008

Acta Cir. Bras.

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Purpose: The transanal procedure for rectal cancer surgery is one of the many techniques currently available. Different techniques for local excision of rectal tumors include: conventional transanal technique, posterior access surgery, therapeutic colonoscopy, transanal endoscopic surgery. Methods: The aim of the present study is to describe a new method of transanal endoscopic resection, transanal endoscopic operation (TEO), and performed with the aid of a surgical proctoscope especially designed for this purpose and report the results obtained in 32 patients submitted to the TEO and to compare these results with those obtained with other techniques currently available. The average proportions of recurrence, postoperation complications and posterior resections were analyzed by means of a metanalysis. Data on the distance and size of rectal lesions, the operative timing and hospitalization time were distributed in graphs according to authors and techniques. Results: The results were favorable and equivalent to those described in the literature. Conclusions: The surgical proctoscope specially designed for this study is efficient and has a low cost; the TEO is easily performed with the aid of this equipment; the final results were favorable and similar to those obtained with other available techniques for endoscopic transanal intestinal resection, which are of high cost and less availability.Key words: Rectal Surgery. Endoscopy. RESUMOIntrodução: A operação cirúrgica por acesso transanal no tratamento do câncer retal é uma das várias técnicas utilizadas nessa terapêutica. Há várias técnicas de excisão local para os tumores retais: O método cirúrgico transanal convencional, acessos posteriores, colonoscopia terapêutica e operações transanais endoscópicas. O objetivo é apresentar um novo método de ressecção transanal endoscópica (Operação Transanal Endoscópica -OTE), realizada com um proctoscópio cirúrgico idealizado para o procedimento e divulgar os resultados obtidos em 32 pacientes submetidos a OTE e compará-los com as técnicas atualmente empregadas. Métodos: Foram analisadas as proporções médias da recorrência, das complicações pós-operatórias e das ressecções posteriores por meio da técnica de metanálise. Para a distância e o tamanho das lesões retais, os tempos de operação e de hospitalização, foram feitos gráficos de acordo com o autor e a técnica. Resultados: Os resultados foram favoráveis e equiparáveis aos trabalhos analisados. Conclusão: Concluiu-se que: O proctoscópio utilizado na OTE demonstrou ser eficaz e de baixo custo; 2 -A OTE mostrou-se factível; 3 -A análise dos resultados com a OTE foram satisfatórios e similares às outras técnicas de ressecções transanais endoscópicas que são de alto custo e pouco disponíveis em nosso meio.Descritores: Cirurgia Retal. Endoscopia. Rocha JJR et al 94

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Lymphatic spread and its prognostic value in patients with rectal cancer

Cited by 225 publications

References 25 publications

Prognostic Determinants of Patients With Lateral Nodal Involvement by Rectal Cancer

Prognostic Determinants of Patients With Lateral Nodal Involvement by Rectal Cancer

Modern Management of Rectal Cancer

Transanal endoscopic operation: a new proposal

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