Lymphatic vessel density in radical prostatectomy specimens

Liu, Cheng; Bishop, Elena; Zhou, Honghong; MacLennan, Gregory T.; López-Beltrán, Antonio; Zhang, Shaobo; Badve, Sunil; Baldridge, Lee Ann; Montironi, Rodolfo

doi:10.1016/j.humpath.2007.09.006

Cited by 22 publications

(18 citation statements)

References 23 publications

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“…Some studies suggest that lymph vessel density inside intratumoral compartment of prostatic carcinoma is reduced [22,23] as it is in our study. Roma et al [22] associated higher peritumoral lymphatic vessel density with higher Gleason score and peritumoral invasion with frequent lymph node metastasis.…”

Section: Discussionsupporting

confidence: 75%

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Periacinar Retraction Clefting and D2-40 Expression in Prostatic Adenocarcinoma

Ulamec

Džombeta

Čupić

et al. 2011

Pathol. Oncol. Res.

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Retraction clefting is known to appear in various types of tumors, but it has only recently been recognized as a specific histological phenomenon. Previously, it was considered merely a laboratory procedure artifact, but lately, there have been some assumptions that peritumoral retractions actually represent lymphatic spaces. In our study, we analyzed neoplastic glands in 52 specimens of prostatic adenocarcinoma. Immunohistochemical analysis was performed using D2-40 antibody, to highlight lymphatic endothelium and thereby differentiate actual lymph vessels or lymphovascular invasion from periacinar retractions. Our results showed that the number of lymph vessels was significantly lower in tumorous tissue compared to adjacent normal prostatic tissue. On the other hand, the number of lymph vessels in tumorous tissue was significantly higher than the number of lymph vessels mimicking periacinar retractions. Overall, the number of lymph vessels mimicking periacinar clefts was particularly low. These results are in accordance with our previous studies, which had shown that periacinar clefting appears due to lack of basal cells and stromal changes around tumorous acini. Also, these results support our hypothesis that retractions do not represent lymph vessels but should be considered a distinct entity, which is proven to be helpful both as diagnostic and predictive factor.

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Section: Discussionsupporting

confidence: 75%

“…Roma et al [22] associated higher peritumoral lymphatic vessel density with higher Gleason score and peritumoral invasion with frequent lymph node metastasis. Cheng et al [23] did not correlate these findings and concluded that quantification of lymphangiogenesis in prostate adenocarcinoma does not offer useful prognostic information.…”

Section: Discussionmentioning

confidence: 99%

Periacinar Retraction Clefting and D2-40 Expression in Prostatic Adenocarcinoma

Ulamec

Džombeta

Čupić

et al. 2011

Pathol. Oncol. Res.

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“…All samples exhibited D2-40 expression in intratumoral, peritumoral, and normal tissue. The greater LVD found in peritumoral versus intratumoral tissue described in this study is in line with similar investigations of clear cell renal carcinoma, prostatic adenocarcinoma, and transitional cell carcinoma of the urinary bladder [13][14][15]. This finding seems to diminish the role of intratumoral lymphatics, which are often malfunctioning and structurally abnormal.…”

Section: Discussionsupporting

confidence: 92%

D2-40 immunoreactivity in penile squamous cell carcinoma: a marker of aggressiveness

et al. 2011

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“…Many researches have proved that MVD remained significant in predicting recurrence and MVD was an important predictor of metastatic disease and an independent predictor of tumor [24][25][26]. Just like MVD, many studies have demonstrated that LVD is an independent prognostic factor in many malignant tumors too [27][28]. But the relationship between LVD and the tumor metastasis remains controversial.…”

Section: Discussionmentioning

confidence: 99%