Lymphatic Vessel Pumping

Weid, Pierre‐Yves von der

doi:10.1007/978-981-13-5895-1_15

Cited by 26 publications

(19 citation statements)

References 116 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Many of the immunoenhancing effects of exercise are direct, including "priming" of the cells mobilized by exercise, improving their tissue migration capacity, cytotoxic function, and the ability to recognize antigens [11]. Other effects of exercise include immune cell metabolic reprogramming, anti-inflammatory signaling [11], and effects on the lymphatic system [25]. For example, although lymph is thought to primarily circulate due to intrinsic lymphatic pumping, extrinsic compression caused by skeletal muscle contraction, respiratory activity, and bodily movement also contribute [25].…”

Section: Physical Activity and The Immune Systemmentioning

confidence: 99%

“…Other effects of exercise include immune cell metabolic reprogramming, anti-inflammatory signaling [11], and effects on the lymphatic system [25]. For example, although lymph is thought to primarily circulate due to intrinsic lymphatic pumping, extrinsic compression caused by skeletal muscle contraction, respiratory activity, and bodily movement also contribute [25]. Thus, being physically active may facilitate the circulation of lymph within the lymphatic vessels, further enhancing the ability of the immune system to respond to antigens [25].…”

Section: Physical Activity and The Immune Systemmentioning

confidence: 99%

See 1 more Smart Citation

Immunological Implications of Physical Inactivity among Older Adults during the COVID-19 Pandemic

et al. 2020

View full text Add to dashboard Cite

Social distancing has been adopted worldwide to control severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission. Social isolation is likely to lead to a decline in physical activity, which could result in immune system dysfunction, thereby increasing infection susceptibility and exacerbating the pathophysiology of conditions that are common among older adults, including cardiovascular disease, cancer, and inflammatory disorders. Older adults and people living with these comorbidities are at a greater risk for complications during coronavirus disease 2019 (COVID-19). In this review, we discuss the negative impact of physical inactivity on immune function and showcase evidence that regular physical activity may be an effective strategy to counter some of the deleterious effects of social isolation. Furthermore, we briefly highlight key research questions in exercise immunology, with a focus on older adults in the context of COVID-19. Although it is worth emphasizing that there is no direct evidence that physical activity can prevent or treat COVID-19, promoting an active lifestyle is a key intervention to counteract the effects of social isolation, especially in older adults and other at-risk individuals, such as those living with chronic diseases associated with ageing and lifestyle.

show abstract

Section: Physical Activity and The Immune Systemmentioning

confidence: 99%

Section: Physical Activity and The Immune Systemmentioning

confidence: 99%

Immunological Implications of Physical Inactivity among Older Adults during the COVID-19 Pandemic

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Unlike lymphatic capillaries, collecting vessels have continuous "zipper-like" endothelial junctions that prevent lymph leakage (Baluk et al, 2007;Yao et al, 2012). Collecting vessels are covered with continuous basement membrane and lymphatic muscle cells with contractile ability (Bridenbaugh et al, 2003;von der Weid and Zawieja, 2004;von der Weid, 2019). Collecting lymphatic vessels contain lymphatic valves (LVs), which regulate the unidirectional flow of lymph.…”

Section: Lymphatic Vascular Architecturementioning

confidence: 99%

Lymphatic Vasculature in Energy Homeostasis and Obesity

Srinivasan

2020

Front. Physiol.

View full text Add to dashboard Cite

Obesity is a leading cause of cardiovascular diseases and cancer. Body mass is regulated by the balance between energy uptake and energy expenditure. The etiology of obesity is determined by multiple factors including genetics, nutrient absorption, and inflammation. Lymphatic vasculature is starting to be appreciated as a critical modulator of metabolism and obesity. The primary function of lymphatic vasculature is to maintain interstitial fluid homeostasis. Lymphatic vessels absorb fluids that extravasate from blood vessels and return them to blood circulation. In addition, lymphatic vessels absorb digested lipids from the intestine and regulate inflammation. Hence, lymphatic vessels could be an exciting target for treating obesity. In this article, we will review our current understanding regarding the relationship between lymphatic vasculature and obesity, and highlight some open questions.

show abstract

“…Approximately 10% of blood plasma leaks out of the blood vessel capillaries and enters the interstitial space, with approximately 5-8 L of plasma pushed into the interstitium each day. 1,2 As shown in Figure 1, this fluid enters the lymphatic system through highly permeable lymphatic capillaries, which feed the fluid, now called lymph, into the larger lymphatic vessels. Since there is no central pump in the lymphatic system, fluid flow in lymphatic vessels is generated by the contraction and relaxation of the surrounding tissues.…”

Section: Introductionmentioning

confidence: 99%

Overcoming physiological barriers by nanoparticles for intravenous drug delivery to the lymph nodes

Trac

Chung

2021

Exp Biol Med (Maywood)

View full text Add to dashboard Cite

The lymph nodes are major sites of cancer metastasis and immune activity, and thus represent important clinical targets. Although not as well-studied compared to subcutaneous administration, intravenous drug delivery is advantageous for lymph node delivery as it is commonly practiced in the clinic and has the potential to deliver therapeutics systemically to all lymph nodes. However, rapid clearance by the mononuclear phagocyte system, tight junctions of the blood vascular endothelium, and the collagenous matrix of the interstitium can limit the efficiency of lymph node drug delivery, which has prompted research into the design of nanoparticle-based drug delivery systems. In this mini review, we describe the physiological and biological barriers to lymph node targeting, how they inform nanoparticle design, and discuss the future outlook of lymph node targeting.

show abstract

Lymphatic Vessel Pumping

Cited by 26 publications

References 116 publications

Immunological Implications of Physical Inactivity among Older Adults during the COVID-19 Pandemic

Immunological Implications of Physical Inactivity among Older Adults during the COVID-19 Pandemic

Lymphatic Vasculature in Energy Homeostasis and Obesity

Overcoming physiological barriers by nanoparticles for intravenous drug delivery to the lymph nodes

Contact Info

Product

Resources

About