Lymphatic vessels in health and disease

Kesler, Cristina T.; Liao, Shan; Munn, Lance L.; Padera, Timothy P.

doi:10.1002/wsbm.1201

Cited by 71 publications

(66 citation statements)

References 131 publications

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“…Lymphatic vasculature functions as a parallel collection circuit to blood vessels in most tissues and organs; this system also actively regulates the fluid balance, lipid transport, and immune cell trafficking. Lymphatics are the main route for collecting filtered interstitial fluid and cells in tissues [39]. Therefore, reduced lymphatic may lead to failure of interstitial fluid conduction and subsequent increase in interstitial fluid accumulation, pressure, and edema.…”

Section: Discussionmentioning

confidence: 99%

The defect of both angiogenesis and lymphangiogenesis is involved in preeclampsia

Liu

Zhang

et al. 2015

Placenta

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Section: Discussionmentioning

confidence: 99%

The defect of both angiogenesis and lymphangiogenesis is involved in preeclampsia

Liu

Zhang

et al. 2015

Placenta

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“…Tumour cells express and secrete lymphangiogenic factors, including VEGFC/D, angiopoietins, PDGF-BB/AA and bFGF to promote tumour lymphangiogenesis, the formation of new LV in the tumour stroma (Refs 15, 79, 80). LV are distinct from BV in their anatomy, growth signals, gene expression and functions (Refs 16, 81).…”

Section: Angiogenesis and Lymphangiogenesis In Cancermentioning

confidence: 99%

“…It is, however, well understood that the tumour lymphatic vasculature serves as the initial route of tumour lymphatic dissemination (Ref. 80). Lymphatic metastasis occurs at least as frequently as BV-mediated metastasis (Ref.…”

Section: Angiogenesis and Lymphangiogenesis In Cancermentioning

confidence: 99%

Crosstalk between cancer cells and blood endothelial and lymphatic endothelial cells in tumour and organ microenvironment

Lee

Pandey

Popel

2015

Expert Rev. Mol. Med.

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Tumour and organ microenvironments are crucial for cancer progression and metastasis. Crosstalk between multiple non-malignant cell types in the microenvironments and cancer cells promotes tumour growth and metastasis. Blood and lymphatic endothelial cells (BEC and LEC) are two of the components in the microenvironments. Tumour blood vessels (BV), comprising BEC, serve as conduits for blood supply into the tumour, and are important for tumour growth as well as haematogenous tumour dissemination. Lymphatic vessels (LV), comprising LEC, which are relatively leaky compared with BV, are essential for lymphogenous tumour dissemination. In addition to describing the conventional roles of the BV and LV, we also discuss newly emerging roles of these endothelial cells: their crosstalk with cancer cells via molecules secreted by the BEC and LEC (also called angiocrine and lymphangiocrine factors). This review suggests that BEC and LEC in various microenvironments can be orchestrators of tumour progression and proposes new mechanism-based strategies to discover new therapies to supplement conventional anti-angiogenic and anti-lymphangiogenic therapies.

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“…The lymphatic system is present in all vascularized tissues and organs, including the central nervous system [16]. It is a network of lymphatic vessels and nodes that transport the lymph into the venous system, and it is an integral part of the immune system [15].…”

Section: General Characteristics Of the Lymphatic System: Invariant Fmentioning

confidence: 99%

Developing Computational Geometry and Network Graph Models of Human Lymphatic System

et al. 2017

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Abstract:The lymphatic system is a body-wide network of lymphatic vessels and lymphoid organs. The complexity of the structural and functional organization of the lymphatic system implies the necessity of using computational modeling approaches to unravel the mechanisms of its regulation in quantitative terms. Although it is a vital part of the circulatory and immune systems, the lymphatic system remains poorly investigated as a mathematical modeling object. Modeling of the lymphatic vessel network needs to be established using a systematic approach in order to advance the model-driven research of this important physiological system. In our study, we elucidate key general features underlying the 3D structural organization of the lymphatic system in order to develop computational geometry and network graph models of the human lymphatic system based on available anatomical data (from the PlasticBoy project), which provides an estimate of the structure of the lymphatic system, and to analyze the topological properties of the resulting models.

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Lymphatic vessels in health and disease

Cited by 71 publications

References 131 publications

The defect of both angiogenesis and lymphangiogenesis is involved in preeclampsia

The defect of both angiogenesis and lymphangiogenesis is involved in preeclampsia

Crosstalk between cancer cells and blood endothelial and lymphatic endothelial cells in tumour and organ microenvironment

Developing Computational Geometry and Network Graph Models of Human Lymphatic System

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