Lymphatico-venous communications in the common rat and their significance

Lymphatic drainage in renal cell carcinoma: back to the basics

“…To confirm these findings, Engeset injected 22 laboratory rats and five wild rats with metallic mercury under the experimental conditions laid out by Job , but found no evidence of abdominal lymphovenous communication (Fig. ).…”

“…Job extensively investigated these communications in a single species of common rat. He injected 100 specimens with a Berlin blue gelatin mass and India ink and reported inferior vena cava communications in 48 of these cases, iliolumbar communications in two cases, renal vein communications in eight cases and portal vein communications in 27 cases .…”

“…It is plausible that peripheral lymphovenous connections arise or disappear at birth, through aging or under pathological conditions. Revisiting this subject, which was once studied in mammals [], may provide insight into the temporality of haematogenous and lymphogenous metastasis in RCC. Most importantly, it would establish a paradigm for the understanding of the pathogenesis of the disease.…”