Lymphoblast transcriptome analysis in 22q11.2 deletion syndrome individuals with schizophrenia-spectrum disorder

Michaelovsky, Elena; Carmel, Miri; Gothelf, Doron; Weizman, Abraham

doi:10.1080/15622975.2024.2327030

Cited by 1 publication

(1 citation statement)

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“…Obtaining neurons or neuronal cells from living human subjects is challenging. However, previous studies have suggested that LCLs can be used to identify biologically plausible links between candidate genes and various psychiatric disorders ( 39 – 41 ), including ASD ( 42 ). Therefore, we assessed the NARP mRNA levels in LCLs derived from adolescents with ASD and typically developing (TD) adolescents.…”

Section: Resultsmentioning

confidence: 99%

NARP-related alterations in the excitatory and inhibitory circuitry of socially isolated mice: developmental insights and implications for autism spectrum disorder

Yamaguchi,

Okamura,

Yamamuro

et al. 2024

Front. Psychiatry

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BackgroundSocial isolation during critical periods of development is associated with alterations in behavior and neuronal circuitry. This study aimed to investigate the immediate and developmental effects of social isolation on firing properties, neuronal activity-regulated pentraxin (NARP) and parvalbumin (PV) expression in the prefrontal cortex (PFC), social behavior in juvenile socially isolated mice, and the biological relevance of NARP expression in autism spectrum disorder (ASD).MethodsMice were subjected to social isolation during postnatal days 21–35 (P21–P35) and were compared with group-housed control mice. Firing properties in the PFC pyramidal neurons were altered in P35 socially isolated mice, which might be associated with alterations in NARP and PV expression.ResultsIn adulthood, mice that underwent juvenile social isolation exhibited difficulty distinguishing between novel and familiar mice during a social memory task, while maintaining similar levels of social interaction as the control mice. Furthermore, a marked decrease in NARP expression in lymphoblastoid cell lines derived from adolescent humans with ASD as compared to typically developing (TD) humans was found.ConclusionOur study highlights the role of electrophysiological properties, as well as NARP and PV expression in the PFC in mediating the developmental consequences of social isolation on behavior.

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Section: Resultsmentioning

confidence: 99%