Lymphocyte changes in beta-thalassaemia major.

Musumeci, Salvatore; Schilirò, G; Romeo, Maria Antonietta; Sciotto, A.; Rosalba, A; Pizzarelli, G

doi:10.1136/adc.54.12.954

Cited by 17 publications

(13 citation statements)

References 9 publications

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“…deficient suppressor activity, must also be considered. A reduction of peripher al E-rosetting cells has recently been report ed in these patients [9], We also observed this in some of our not yet transfused pa tients, even after incubation with thymic hormone (TP-1 Serono®, Rome, Italy). However, the increased humoral response to exogenous antigen, but not to host anti gen, is not in accordance with this hypothe sis.…”

Section: Discussionsupporting

confidence: 57%

Serum Immunoglobulins in Homozygous β-Thalassemia

et al. 1981

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IgG, IgA and IgM levels were studied in 187 homozygous β-thalassemic patients and compared with age-matched normal control subjects. The not yet transfused and the polytransfused nonsplenectomized patients showed a significant increase of all Ig classes. The polytransfused splenectomized patients showed a significant increase only of IgG and IgA. The splenectomized patients, when compared to the nonsplenectomized ones, showed a significant increase of IgG, of IgA in the elder ones and a significant reduction of IgM. High ASLO and ASFLO titers were found especially in the splenectomized patients. The high Ig levels in younger not yet transfused patients, with little iron storage and normal hepatic enzyme values, demonstrate that transfusion therapy and liver damage do not play a main role in hypergammaglobulinemia. The absence of antimitochondrial, anticonnective tissue and homogeneous antinuclear antibodies seems to exclude a deficient suppressor mechanism. The hemocatheteric ‘overworking’ of RES may reduce the antigen clearance with a consequent increase of antibody response. Splenectomy, by removing a consistent part of RES, enhances the phenomenon.

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Section: Discussionsupporting

confidence: 57%

Serum Immunoglobulins in Homozygous β-Thalassemia

et al. 1981

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“…In our study, all thalassemia patients showed lower NK cytotoxic activity in comparison to healthy subjects, prob ably as a consequence of multiple blood transfusions and/ or repeated viral infections, confirming the immunodefi ciency of thalassemia patients [31]. Moreover, the re duced NK activity before a-IFN treatment in thalassemia patients could be due to a poor production of a-IFN, which is essential for natural cytotoxicity.…”

Section: Resultsmentioning

confidence: 52%

Effect of Alpha-interferon on Natural Killer Cell Activity and Lymphocyte Subsets in Thalassemia Patients with Chronic Hepatitis C

Malaponte

Passero²,

Leonardi³

et al. 1997

Acta Haematol

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The variation of natural killer (NK) cell activity and lymphocyte subsets 20 h after a single test dose of α-IFN, was studied in 17 thalassemic patients with chronic hepatitis C. All patients had suspended the α-IFN therapy at least 12 months before the study: 10 were considered responders and 7 nonresponders. Also NK cell cytotoxicity after in vitro incubation with α-IFN was studied. The administration of a single dose of α-IFN increased NK cell cytotoxic activity significantly in the group of responders and in non-responders; moreover the NK cell cytotoxic activity after α-IFN in vitro incubation increased both in responders and nonresponders, but to a lesser degree than in healthy controls. Absolute values of CD4+ and CD8+ lymphocytes decreased significantly only in responders. In conclusion, our data suggest that the variation of NK cytotoxic activity and lymphocyte subsets after a test dose of α-IFN can be considered a parameter related to IFN biological effects.

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“…In the present study we assessed NK ac tivity and T lymphocyte subpopulations in homozygous beta thalassemia, a severe transfusion-dependent anemia, in which some studies of cell-mediated immunity have been so far reported [4,13,19,21]. Patients with hemoglobinopathies suffer rather frequently from bacterial and viral infections; furthermore, the incidence of malignancies in thalassemia major (TM) may be an issue of interest, since hyper transfusion regimens together with inten sive removal of iron excess have signifi cantly improved the outcome of the dis ease, and at present the life expectancy of these subjects is lengthened [ 16],…”

Section: Introductionmentioning

confidence: 99%

Natural Killer Cell Activity and T Subpopulations in Thalassemia major

Neri¹,

Brugiatelli²,

Iacopino³

et al. 1984

Acta Haematol

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Natural killer (NK) cell activity against K562 cell targets and the distribution of T cell subpopulations were investigated in the peripheral blood of 25 patients affected by beta thalassemia major, 18 clinically healthy heterozygotes, and 25 age-matched normal subjects. It was found that thalassemia major patients display augmented levels of NK activity [specific lysis 41.9+ (se) 4.5%], while thalassemic carriers behave as normal controls [specific lysis 34.6+ (se) 3.5%]. The increase of NK function was neither related to the splenectomy nor to the siderosis, but rather to the age and the amount of blood units that the patients had received. An imbalance of circulating T subsets with the helper/suppressor cell ratio significantly diminished (p < 0.001) was also detected in homozygotes but not in carriers. The finding that NK function is enhanced in homozygous beta thalassemia might be of clinical interest in assessing the risk of development of malignancies in these patients.

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Lymphocyte changes in beta-thalassaemia major.

Cited by 17 publications

References 9 publications

Serum Immunoglobulins in Homozygous β-Thalassemia

Serum Immunoglobulins in Homozygous β-Thalassemia

Effect of Alpha-interferon on Natural Killer Cell Activity and Lymphocyte Subsets in Thalassemia Patients with Chronic Hepatitis C

Natural Killer Cell Activity and T Subpopulations in Thalassemia major

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