Lymphocyte Function in Major Depressive Disorder

Schleifer, Steven J.; Keller, Steven E.; Meyerson, Arthur T.; Raskin, Marjorie; Davis, Kenneth L.; Stein, Mary Kay

doi:10.1001/archpsyc.1984.01790160070008

Cited by 361 publications

(90 citation statements)

References 26 publications

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“…The higher DPM following PWM stimulation in depressed patients did not reach even trend level. Our results differ from several observations reporting a clear-cut attenuated mitogen response following administration of various lectins in depressed patients (Kronfol et al 1983;Schleifer et al 1984;Cosyns et al 1989). However, the mitogen-induced blastogenesis has recently been attributed more to factors such as age, severity of depression, and hospitalization effects than to the diagnosis itself (Schleifer et al 1989).…”

Section: Discussioncontrasting

confidence: 99%

“…A variety of studies have investigated lymphocyte subsets (Schleifer et al 1989), natural killer cell activity (Irwin et al 1988;Schleifer et al 1989), and the mitogen response to various lectins (Kronfol et al 1983;Schleifer et al 1984Schleifer et al , 1985Cosyns et al 1989). Although initial studies reported a decreased mitogen-induced leucocyte proliferation in depressed patients (Kronfol et al 1983;Schleifer et al 1984), this could not be consistently reproduced in later investigations (Schleifer et al 1985). Instead, other variables, such as age and severity of depression, seemed to play a key role for the lectin-induced blastogenesis (Schleifer et al 1989).…”

Section: Introductionmentioning

confidence: 99%

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In vivo and in vitro effects of glucocorticoids on lymphocyte proliferation in depression

Rupprecht

Wodarz

Kornhuber

et al. 1991

Eur Arch Psychiatry Clin Nuerosci

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European "D~I rg'~'~ Ir t"l~'I r Archives of 1~ y Ik.lllOl.lkl. Summary. Twelve severely depressed patients and 13 healthy controls were studied under baseline, metyrapone and metyrapone plus dexamethasone pretreated conditions. Lymphocyte proliferation data were obtained by concanavalin A, phytohaemagglutinin and pokeweed mitogen (PWM) stimulation. There was a decrease in PWM-induced B-cell proliferation and an increase in inhibition of spontaneous leucocyte proliferation by dexamethasone added in vitro following metyrapone administration in vivo, in healthy controls, which was not present in the depressed patients. These data support the concept of a decreased functional plasticity of the glucocorticoid receptor in depression also at the cellular level.

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Section: Discussioncontrasting

confidence: 99%

Section: Introductionmentioning

confidence: 99%

In vivo and in vitro effects of glucocorticoids on lymphocyte proliferation in depression

Rupprecht

Wodarz

Kornhuber

et al. 1991

Eur Arch Psychiatry Clin Nuerosci

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“…As an example, mood states such as depression are associated with dysregulation of the pituitary-adrenal system (Holsboer, Von Bardeleben, Gerken, Stalla, & Muller, 1984), and depressed individuals often have chronically elevated levels of glucocorticoids in blood (Carrol, 1978). As would therefore be expected, immune system dysfunction has often been reported to exist in depressed populations (Irwin, Daniels, Bloom, Smith, & Weiner, 1987;Schleifer et al, 1984). Emotions such as anger and anxiety might also be expected ultimately to impact on immunity (Fleshner et al, 1993).…”

Section: Stress and Immunitymentioning

confidence: 96%

Psychoneuroimmunology: The interface between behavior, brain, and immunity.

Maier¹,

Watkins²,

Fleshner³

1994

American Psychologist

326

168

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Psychoneuroimmunology is the study of interactions between behavior, the brain, and the immune system. This article is designed to provide an overview of this new field for the general psychologist. The existence of bidirectional communication pathways between the brain and the immune system and the implications of this network for behavior are emphasized. Implications are that behavioralpsychological processes ought to be capable of altering immune function and that events that occur as part of immune responses should modulate behavior. Evidence for influences in both of these directions is reviewed. The discussion of psychological modulation of immunity focuses on classical conditioning and stress, whereas that of immune modification of behavior highlights behavioral effects produced by substances released by the immune system. Finally, the adaptive role that such changes might play is considered. Lyle E. Bourne served as action editor for this article.

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“…Early studies primarily examined adaptive immune responses and indicated that T and B cells from patients with major depression exhibited decreased proliferation following a variety of stimuli including the mitogens phytohemagglutinin and pokeweed mitogen (Schleifer et al, 1984;Stein et al, 1991;Zorrilla et al, 2001). Decreases in the number and activity of NK cells, which are believed to straddle adaptive and innate divisions of the immune system, were also described (Stein et al, 1991;Zorrilla et al, 2001).…”

Section: Foundations For the Hypothesis That The Immune System Plays mentioning

confidence: 99%

Therapeutic Implications of Brain–Immune Interactions: Treatment in Translation

Miller

Haroon

Felger

2016

Neuropsychopharmacol

119

124

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A wealth of data has been amassed that details a complex, yet accessible, series of pathways by which the immune system, notably inflammation, can influence the brain and behavior. These data have opened the window to a diverse array of novel targets whose potential efficacy is tied to specific neurotransmitters and neurocircuits as well as specific behaviors. What is clear is that the impact of inflammation on the brain cuts across psychiatric disorders and engages dopaminergic and glutamatergic pathways that regulate motivation and motor activity as well as the sensitivity to threat. Given the ability to identify patient populations with increased inflammation, the precision of interventions can be further tuned, in conjunction with the ability to establish target engagement in the brain through the use of multiple neuroimaging strategies. After a brief overview of the mechanisms by which inflammation affects the brain and behavior, this review examines the extant literature on the efficacy of anti-inflammatory treatments, while forging guidelines for future intelligent clinical trial design. An examination of the most promising therapeutic strategies is also provided, along with some of the most exciting clinical trials that are currently being planned or underway.

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Lymphocyte Function in Major Depressive Disorder

Cited by 361 publications

References 26 publications

In vivo and in vitro effects of glucocorticoids on lymphocyte proliferation in depression

In vivo and in vitro effects of glucocorticoids on lymphocyte proliferation in depression

Psychoneuroimmunology: The interface between behavior, brain, and immunity.

Therapeutic Implications of Brain–Immune Interactions: Treatment in Translation

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