Lymphocyte Index of Peripheral Blood in Rats at Different Stages of the Post-Stress Period under Conditions of Antigenic Exposure and Injection of Lipopolysaccharide

Abstract

Changes in the Shaganin lymphocyte index (ratio of the number of lymphocytes to segmented neutrophils) in the peripheral blood of rats after intraperitoneal administration of LPS (100 μg/kg) at the end of a single stress exposure in a model of 24-h restraint stress were studied. The lymphocyte index was analyzed 3 h later, on the 1st and 8th days after the stress load. Immobilization was accompanied by a decrease in this parameter 3 h after exposure. One day after the stress load, an increase in the lymphocyte index was noted, which remained on the 8th day of observation. LPS injection did not affect the changes in this parameter caused by 24-h immobilization on the 1st and 8th days of the study, but prevented a pronounced increase in the lymphocyte index on the 1st day after the stress load. The data obtained expand the existing scientific understanding of the specificity of the involvement of immunomodulatory substances in the implementation of adaptive-compensatory processes in mammals under conditions of emotional stress.

Morphological Changes of Peri-Coronary Adipose Tissue Together with Elevated NLR in Acute Myocardial Infarction Patients in-Hospital

“…Additionally, lymphocytes play a pivotal role in inflammation regulation, 42 acting as key immune modulators that may decrease in number under stress conditions. 43 The NLR is a comprehensive marker that combines the strengths of neutrophils and lymphocytes in reflecting the severity of atherosclerotic lesions, thus compensating for their individual limitations. 27 , 28 It offers a more accurate assessment of the body’s inflammatory and stress levels.…”

Effects of fermented Andrographis paniculata on growth performance, carcass traits, immune function, and intestinal health in Muscovy ducks

“…Most of the peripheral blood lymphocytes of Muscovy ducks are T cells, which are important in mediating cellular immunity ( Wu et al, 2019 ). After stimulation with nonspecific antigen ConA in vitro, they can transform into lymphoblasts for lymphocyte proliferation ( Alekseeva et al, 2021 ). Therefore, the degree of T lymphocyte transformation and proliferation reflects the level of cellular immunity in the body ( Hafez et al, 2020 ).…”