Lymphocyte Migration Patterns in Autoimmune MRL-lpr/lpr Mice: Relationship to Age, Disease Manifestations and Lymphocyte Homing Receptor Expression

Schrieber, Leslie; Manolios, Nicholas; Cohen, M. G.; Paull, S. A.; Guiffre, A.; Hopper, K.

doi:10.3109/08916938909043609

Cited by 3 publications

(2 citation statements)

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“…Similarly, PGE2 levels from unstimulated lymph node cells of CBA/T6 and MRL/n mice were comparable (3 months, 1 year, 18 months). These observations argue against the influence of AA metabolites in the abnormal migration profiles observed in SLE mice (8).…”

Section: Discussionmentioning

confidence: 94%

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Arachidonic acid metabolites in normal and autoimmune mice do not influence lymphocyte‐high endothelial venule interactions

Manolios

Bakiera

Geczy

et al. 1991

Immunology & Cell Biology

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Summary In peripheral lymphoid organs tbe number of lymphocytes and the proportion of functional lymphocyte subsets are regulated by multiple factors including tbe control of lymphocyte migration by selective lymphocyte-higb endothelial venule (HEV) interactions. In this study, prostaglandin E2 (PGE2) levels from normal and autoimmune mouse lymph node cells were measured. The contribution of eicosanoids to lymphocyte-HEV interactions in normal (CBA/T6) and autoimmune {MRL/n) mice was examined. There was no association between PGE2 production in normal or autoimmune mice and the age of onset of disease activity in the latter strains. Aracbidonic acid metabolites, in particular PGE2 and leukotriene B4 (LTB4), did not bave any effects on lympbocyte-HEV binding. Likewise, lymphocytes treated in vivo and/or in vitro with arachidonic acid metabolite inhibitors (acetyl salicylic acid, indomethacin, BW755C) did not alter lymphocyte-HEV binding interactions in both normal and autoimmune mice. No clinical significance could be attributed to lymph node PGE2 production and the age of onset of autoimmune disease. In summary, these findings cast doubt on tbe role of arachidonic acid metabolites in lymphocyte-HEV binding interactions.

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Section: Discussionmentioning

confidence: 94%

“…They also exhibit abnormal accumulation of lymphocytes at lymphoidal (lymph nodes, spleen) and extralymphoidal (kidneys, lungs, synovium) sites. Differences in the lymphocyte homing receptor expression in MRIVl mice did not account for the abnormal lymphocyte trafficking profile (8).…”

Section: Introductionmentioning

confidence: 89%

Arachidonic acid metabolites in normal and autoimmune mice do not influence lymphocyte‐high endothelial venule interactions

Manolios

Bakiera

Geczy

et al. 1991

Immunology & Cell Biology

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Lymphocyte migration in health and inflammatory rheumatic disease

Manolios¹,

Geczy

Schrieber

1991

Seminars in Arthritis and Rheumatism

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Aberrant Lymphocyte Migration Patterns in Systemic Lupus Erythematosus (MRL/l, MRL/n) Mice are Independent of the Micro-Environment

1990

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Mice with systemic lupus erythematosus (SLE) have unusual patterns of lymphocyte traffic characterised by diminished uptake of intravenously injected autoimmune cells into lymph nodes. This study examines the influence of the lymphocyte micro-environment on this aberrant migratory behaviour. To evaluate lymph node lymphocyte-endothelial interactions which can affect lymphocyte distribution without the in vivo influence of liver and spleen, the in vitro high endothelial venule (HEV) binding assay was used. Lymph node HEV binding of autoimmune MRL-lpr/lpr (MRL/l) and MRL(-)+/+ (MRL/n) lymphocytes was increased when compared with CBA/T6 lymphocytes and contrasted with diminished lymph node uptake noted in vivo. This was independent of the lymph node source (MRL/l, MRL/n, CBA/T6) onto which the lymphocytes were overlaid. To examine the influence of the microenvironment on in vivo traffic, 21Cr-labelled lymph node cells from normal CBA/T6 mice were injected into sex-matched MRL/l, MRL/n and CBA/T6 recipients. The distribution of cells was the same in each recipient strain suggesting that the micro-environment had little influence on the lymphocyte trafficking profiles of autoimmune mice. This study supports the view that aberrant lymphocyte migration in autoimmune mice results from defects intrinsic to the lymphocyte population and not the micro-environment.

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Lymphocyte Migration Patterns in Autoimmune MRL-lpr/lpr Mice: Relationship to Age, Disease Manifestations and Lymphocyte Homing Receptor Expression

Cited by 3 publications

References 19 publications

Arachidonic acid metabolites in normal and autoimmune mice do not influence lymphocyte‐high endothelial venule interactions

Arachidonic acid metabolites in normal and autoimmune mice do not influence lymphocyte‐high endothelial venule interactions

Lymphocyte migration in health and inflammatory rheumatic disease

Aberrant Lymphocyte Migration Patterns in Systemic Lupus Erythematosus (MRL/l, MRL/n) Mice are Independent of the Micro-Environment

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