Lymphocyte Oxidative Stress/Genotoxic Effects Are Related to Serum IgG and IgA Levels in Coke Oven Workers

Gao, Meili; Li, Yongfei; Zheng, Anqing; Xue, Xiaochang; Chen, Lan; Kong, Yu

doi:10.1155/2014/801346

Cited by 8 publications

(8 citation statements)

References 40 publications

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“…o corroborate this hypothesis future experiments with a larger number of animals should be conducted in order to confirm two requirements: (1) if animals with high antibody titres usually have low values of oxidant compounds and also (2) to provide evidence that oxidant compounds compromises antibody function or half-life. Although there are previous studies that described both requirements [ 17 , 47 , 48 ] ideally this should be demonstrated also with the BM95 and BM86 antigens. If this could be demonstrated, vaccine formulations would benefit from producing an antioxidant response able to keep oxidant agents at low concentrations, in order to avoid oxidation of IgG.…”

Section: Discussionmentioning

confidence: 89%

“…This result could be related to a decrease in protein oxidation and therefore an improvement in the antibody production. High level of oxidants would lead to oxidation and damage of the immunoglobulins [ 17 , 47 ], thus resulting in significant inhibition of antibody activity by altering the secondary or tertiary structure of antibodies [ 19 ]. The lack of changes in FOX could indicate that there is no product of lipid oxidation liberated during the immunization process.…”

Section: Discussionmentioning

confidence: 99%

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Changes in Serum Biomarkers of Oxidative Stress in Cattle Vaccinated with Tick Recombinant Antigens: A Pilot Study

et al. 2020

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Tick vaccination is an environmentally friendly alternative for tick control, pathogen infection, and transmission. Tick vaccine protection is sometimes incomplete, which may be due to problems in the stability, conformation, and activity of antibodies. This might be related to oxidative stress, but more studies are needed about the possible relationships between oxidative stress and immune function. The objective of this study was to evaluate and compare various serum biomarkers of antioxidant response and oxidative damage in cattle vaccinated with two recombinant antigens, the chimera of Subolesin- BM95 (homologue antigen of BM86)-MSP1a and BM86, and a control consisting in the adjuvant of the vaccines. Cupric reducing antioxidant capacity (CUPRAC), ferric reducing ability of the plasma (FRAP), trolox equivalent antioxidant capacity (TEAC), total thiol concentrations, and uric acid were evaluated in serum to determine the antioxidant response. To evaluate oxidative status, ferrous oxidation-xylenol orange (FOX), total oxidant status (TOS), advanced oxidation protein products (AOPP) and hydrogen peroxide (H2O2) concentrations in serum were determined. In addition, correlations between biomarkers of oxidative stress and antibody titers were evaluated. A significant decrease in all antioxidant biomarkers, with exception of thiol, and also a decrease in the oxidant markers TOS, AOPP and H2O2 was observed in cattle vaccinated with BM86, that also showed the highest antibody titers response whereas no significant differences in any of the biomarkers were detected in the Subolesin-Bm95-MSP1a and control groups. In addition, the dynamics of Cuprac and H2O2 with time showed significant differences between the groups. Although this is a pilot study and the results should be interpreted with caution and corroborated by studies involving a large number of animals, our results indicate that, in our experimental conditions, those vaccines able to induce a lower oxidative stress produce a higher concentration of antigen-specific antibodies. Overall, the results of the study provided information on the behavior of different biomarkers related to antioxidant defense, and the oxidative damage in cattle in response to vaccination.

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Section: Discussionmentioning

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Changes in Serum Biomarkers of Oxidative Stress in Cattle Vaccinated with Tick Recombinant Antigens: A Pilot Study

et al. 2020

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“…Researches have proven that oxidative stress can cause abnormal levels of immunoglobulins (Nandakumar et al, 2008 ) and reduce the immune function (Srivastava et al, 2017 ). Gao et al ( 2014 ) found that oxidative stress reduced IgA and IgG levels. High levels of HSPs are observed in the process of oxidative stress.…”

Section: Discussionmentioning

confidence: 99%

Proper cold stimulation starting at an earlier age can enhance immunity and improve adaptability to cold stress in broilers

Xin

et al. 2020

Poultry Science

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The effects of long-term cold stimulation on the immune function of ileum and adaptability to cold stress in broilers were examined. A total of 360 Arbor Acres broilers was divided into 3 groups and four replicates per group. C (control) was reared in normal thermal environment. C-3 and C-12 (treatments) were kept in cold condition of 3 or 12°C lower than the temperature of C from days 8 to 42. At day 42, all the groups were exposed to an acute cold stress challenge, designated as S, S-3, and S-12. The mRNA levels of immune molecules and heat shock proteins as well as oxidative stress-related indicators in ileum tissues, and immunoglobulins contents in serum were examined at 14, 42, and 43 d of age. The C-3 regimen had no adverse effect on production performance, whereas the C-12 regimen reduced the production performance relative to C ( P < 0.05). At day 42, C-3 had higher levels of immune indexes ( P < 0.05), whereas C-12 had lower levels than C ( P < 0.05). No differences in levels of oxidative stress-related indicators were found between C and C-3 at day 42 ( P > 0.05). S-3 had higher levels of immune indexes and lower levels of oxidative stress-related indicators ( P < 0.05), as compared to S and S-12. The results suggest that 34 d of cold stimulation at 3°C lower than the normal temperature had no adverse impacts on production performance but enhanced the immunity of ileum and adaptability to acute cold challenge in broilers.

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“…The immune mechanisms are implicated in chronic inflammatory response, hypertension, vascular dysfunction and deterioration of organs. [4,5,6] Inflammation is a key feature of atherosclerosis. Elevated levels of white blood cells (eosinophils, monocytes, neutrophils, lymphocytes) and the CRP, the immune responses herald adverse cardiac outcomes, endothelial activation, growth and rupture of the plaque.…”

Section: Introductionmentioning

confidence: 99%

Association of Food Intolerance with Coronary Artery Disease

Tsantsaridou¹,

Papathanasiou²,

Dimisianos³

2019

JFNR

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Background: Hippocrates wisely said that «your food be your medicine and that nature is the doctor of diseases». In the Holy Scriptures the «clean from the unclean foods» are separated. In this pilot study, we tried to uncover any intolerances to foods of patients with coronary artery disease. Aim: The purpose of this trial was to evaluate any food categories that stimulate the immune system of patients with coronary heart disease by creating a vicious circle of inflammation, including atherogenesis. The analysis will contribute to possibly understand patients with coronary artery disease, the aetiopathogenesis of the underlying disease and implement the appropriate therapeutic nutrition. Materials and methods: The presence of IgG antibodies were detected using a kit (Golden test) with ELISA method in 63 patients and 12 healthy individuals. Results: The analysis revealed that more frequent intolerances were in banana, milk products and eggs. The tests showed statistical differences for banana and milk among the two groups. Conclusions: Although most patients had an intolerance in bananas, eggs and milk, this work does not verify the association of food intolerances with the etiology of coronary artery disease.

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Lymphocyte Oxidative Stress/Genotoxic Effects Are Related to Serum IgG and IgA Levels in Coke Oven Workers

Cited by 8 publications

References 40 publications

Changes in Serum Biomarkers of Oxidative Stress in Cattle Vaccinated with Tick Recombinant Antigens: A Pilot Study

Changes in Serum Biomarkers of Oxidative Stress in Cattle Vaccinated with Tick Recombinant Antigens: A Pilot Study

Proper cold stimulation starting at an earlier age can enhance immunity and improve adaptability to cold stress in broilers

Association of Food Intolerance with Coronary Artery Disease

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