1990
DOI: 10.1159/000461233
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Lymphocyte Proliferation in AIDS-Related Complex/Walter-Reed 5 Patients: Response to Herpes Simplex Virus and Tuberculin Antigen and Mitogen during Intravenous Immunoglobulin Treatment

Abstract: In a randomized, controlled double-blind study, 15 patients with AIDS-related complex/Walter-Reed 5 (ARC/WR5) were compared during 6 months intravenous immunoglobulin (IVIG) treatment (0.4g/kg body weight every 2 weeks) with 15 placebo-treated patients. This study was aimed at the lymphocyte response to T and B cell mitogens and antigens. 3H-thymidine uptake was determined after stimulation with the unspecific mitogens phytohemagglutinin (PHA), pokeweed mitogen (PWM), formalinized Staphylococcus aureus-Cowan I… Show more

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Cited by 4 publications
(4 citation statements)
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“…Lectins from other ascomycete fungi including other Aspergillus species have not been investigated so far for mitogenic potential. Mitogenic lectins have been routinely used to assess the immunocompetence of patients suffering from a variety of diseases and scrutinize the functioning of immune system under abnormal conditions (Krickeberg et al 1990). This report will prompt the researchers to investigate mitogenic activity among fungal lectins, which has still remained unexplored.…”
Section: Mitogenic Potential Of a Nidulans Lectinmentioning
confidence: 99%
“…Lectins from other ascomycete fungi including other Aspergillus species have not been investigated so far for mitogenic potential. Mitogenic lectins have been routinely used to assess the immunocompetence of patients suffering from a variety of diseases and scrutinize the functioning of immune system under abnormal conditions (Krickeberg et al 1990). This report will prompt the researchers to investigate mitogenic activity among fungal lectins, which has still remained unexplored.…”
Section: Mitogenic Potential Of a Nidulans Lectinmentioning
confidence: 99%
“…Early onset AZT treatmenl mighi be necessary to achieve such an effect. Intravenous IgG treatmenl as in [irevious studies [43][44][45]-did not result in improved immune responses.…”
Section: Discussionmentioning
confidence: 92%
“…In pediatric AIDS, improvement of clinical and immunological parameters has been reported as a result of IVIG therapy with a decreasing number of bacterial infections [l-31. Some observations tend to explain the effects of IVIG as an inhibition of polyclonal B cell proliferation [28] and, thereby, probably as a protection against autoimmune phenomena [28,29].…”
Section: Discussionmentioning
confidence: 99%