Lymphocyte Response in Subjects with Chronic Pulmonary Disease Colonized by <i>Pneumocystis jirovecii</i>

Varela, J.M.; Respaldiza, Nieves; Sánchez, Berta; Horra, Carmen de la; Montes-Cano, Marco Antonio; Rincón, Manuel; Dapena, J.; González-Becerra, C.; Medrano, Francisco J.; Calderón, E.

doi:10.1111/j.1550-7408.2003.tb00680.x

Cited by 19 publications

(11 citation statements)

References 22 publications

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“…Furthermore, the association between P. jirovecii colonization and the severity of COPD raises the possibility that Pneumocystis is involved in the pathogenesis of this condition [11]. Higher peripheral lymphocyte counts with increased CD4 T lymphocyte responses have been reported in subjects with chronic bronchitis, and a systemic inflammatory response with higher serum levels of tumor necrosis factor a, interleukin 6, and interleukin 8 has been documented in patients with COPD and Pneumocystis colonization [10,41].…”

Section: Discussionmentioning

confidence: 99%

PneumocystisColonization Is Highly Prevalent in the Autopsied Lungs of the General Population

Gallo²,

et al. 2010

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Section: Discussionmentioning

confidence: 99%

PneumocystisColonization Is Highly Prevalent in the Autopsied Lungs of the General Population

Gallo²,

et al. 2010

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“…[29][30][31][32] These observations provide a mechanism by which Candida may play a causal role in the increased inflammatory markers and may potentiate worse clinical outcomes. 33 In a recent study, rats instilled with live Candida albicans developed increased pulmonary TNF-a and increased rates of pseudomonal pneumonia; whereas, rats instilled with normal saline or ethanol destroyed the Candida albicans. In critically ill patients, tracheal colonization with Candida spp.…”

Section: Discussionmentioning

confidence: 99%

The relationship between Candida species cultured from the respiratory tract and systemic inflammation in critically ill patients with ventilator-associated pneumonia

Albert

Perreault

Delisle

et al. 2010

Can J Anesth/J Can Anesth

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“…Given the high prevalence of P. jirovecii colonization in numerous studies of COPD patients (10 to 55%), as reviewed by Khodavaisy et al (461), it has been hypothesized that colonization may contribute to the development of some lung diseases, particularly COPD (16,462). In support of this hypothesis, studies with different patient populations have demonstrated that P. jirovecii colonization is associated with a higher risk of airway obstruction (463) and severe COPD (464) and an increased systemic inflammatory response in COPD (465,466). In addition, studies of nonhuman primates with humanized simian-human immunodeficiency virus (SHIV) infection have suggested that Pneumocystis colonization may contribute to the development of COPD (467).…”

Section: Transmissionmentioning

confidence: 94%

A Molecular Window into the Biology and Epidemiology of Pneumocystis spp

2018

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, a unique atypical fungus with an elusive lifestyle, has had an important medical history. It came to prominence as an opportunistic pathogen that not only can cause life-threatening pneumonia in patients with HIV infection and other immunodeficiencies but also can colonize the lungs of healthy individuals from a very early age. The genus includes a group of closely related but heterogeneous organisms that have a worldwide distribution, have been detected in multiple mammalian species, are highly host species specific, inhabit the lungs almost exclusively, and have never convincingly been cultured, making a fascinating but difficult-to-study organism. Improved molecular biologic methodologies have opened a new window into the biology and epidemiology of. Advances include an improved taxonomic classification, identification of an extremely reduced genome and concomitant inability to metabolize and grow independent of the host lungs, insights into its transmission mode, recognition of its widespread colonization in both immunocompetent and immunodeficient hosts, and utilization of strain variation to study drug resistance, epidemiology, and outbreaks of infection among transplant patients. This review summarizes these advances and also identifies some major questions and challenges that need to be addressed to better understand biology and its relevance to clinical care.

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Lymphocyte Response in Subjects with Chronic Pulmonary Disease Colonized by Pneumocystis jirovecii

Cited by 19 publications

References 22 publications

PneumocystisColonization Is Highly Prevalent in the Autopsied Lungs of the General Population

PneumocystisColonization Is Highly Prevalent in the Autopsied Lungs of the General Population

The relationship between Candida species cultured from the respiratory tract and systemic inflammation in critically ill patients with ventilator-associated pneumonia

A Molecular Window into the Biology and Epidemiology of Pneumocystis spp

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