Lymphocyte Rich Hodgkin's Lymphoma Presented with Warm Hemolytic Anemia: A Case Report and Literature Review

Hurtado-Cordovi, Jorge; Verma, Vaibhav; Gotlieb, Vladimir; Frieri, Marianne

doi:10.1155/2011/385408

Cited by 4 publications

(8 citation statements)

References 12 publications

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“…The mechanism of anemia varies; it could be secondary to chronic disease reflecting the underlying malignant process. In advanced disease anemia occurs from bone marrow infiltration by malignant cells [5]. We present a case of hemolytic anemia at the time of diagnosis of classic HL, with a detailed review of the literature of HL accompanied by HA.…”

Section: Incidencementioning

confidence: 99%

“…It was first described in 1832 [4,5]. Since that time, this neoplasm has been extensively studied; currently, it is classified into classic Hodgkin lymphoma (cHL) and lymphocyte predominant variant.…”

Section: Introductionmentioning

confidence: 99%

“…cHL is further divided into four categories-nodular sclerosis, mixed cellularity, lymphocyte rich, and lymphocyte depleted. Other lymphomas, especially primary mediastinal large B cell lymphoma, show borderline histological features similar to cHL [5,6]. In the developed countries, HL roughly accounts for 10 % of all diagnosed lymphomas.…”

Section: Introductionmentioning

confidence: 99%

“…In the developed countries, HL roughly accounts for 10 % of all diagnosed lymphomas. This neoplasm follows a bimodal age distribution having a peak in early adulthood and then in the seventh decade [5]. It has male predominance.…”

Section: Introductionmentioning

confidence: 99%

“…It has male predominance. Worldwide, nodular sclerosis subtype accounts for majority of all cHL, whereas lymphocytic depletion type accounts for less than 1 % [5]. In classical presentations, cervical lymph nodes are involved in approximately three quarters of cases at diagnosis.…”

Section: Introductionmentioning

confidence: 99%

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Lymphocyte Depleted Hodgkin’s Lymphoma Presented with Haemolytic Anemia: A Case Report and Literature Review

Singh¹,

Sheikh²,

Pallagatti³

et al. 2013

J. Maxillofac. Oral Surg.

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Hodgkin's lymphoma accounts for ten per cent of all lymphomas. Lymphomas represent the third most frequent neoplasia on a worldwide scale and constitute 3 % of malignant tumors. In the United States, there are about 8,000 new cases every year. This case report describes a case of lymphocyte-depletion Hodgkin's lymphoma (LDHL) manifested by anemia. LDHL is the least common of the types of Hodgkin's disease, comprising less than 1 % of all cases of this cancer. A 19-year-old Indian male presented with complaint of huge asymptomatic swelling in the right lateral part of neck since 8 months. All the lymph nodes of the right side submandibular, submental, cervical and axillary lymph nodes were rubbery in consistency, tender and were palpable. The CBC revealed hemoglobin of 7.4 gm/dL and ESR count was highly raised up to 125 mm/first hour. Direct Coomb's test detected multiple antibodies IgG type, which was consistent with the diagnosis of Haemolytic anemia. Ultrasonography of the neck showed enlarged discrete lymph nodes on the right side of the neck. For further evaluation patient was subject for ultrasonography of the abdomen which revealed there was of enlargement of both spleen and liver. Lymph node FNAC revealed classic LDHL. Anemia and swelling resolved after completion of chemotherapy with adriamycin, bleomycin, vinblastine, and dacarbazine (ABVD) after 6 cycles. The literature review and our case report discuss the optimal management of this Hodgkin's lymphoma. To our knowledge, this is the first case of LDHL with Haemolytic Anemia treated with only ABVD regime.

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Section: Incidencementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Lymphocyte Depleted Hodgkin’s Lymphoma Presented with Haemolytic Anemia: A Case Report and Literature Review

Singh¹,

Sheikh²,

Pallagatti³

et al. 2013

J. Maxillofac. Oral Surg.

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Eosinophilic Disorders in Various Diseases

Celestin

Frieri

2011

Curr Allergy Asthma Rep

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Peripheral and tissue eosinophilia are usually associated with a variety of inflammatory, malignant, and infectious conditions. As the presence of eosinophils in the tissues may cause significant cellular damage to vital organs such as the heart, tissue eosinophilia should be diagnosed and treated promptly. One operative way to evaluate eosinophilic disorders is to classify them into extrinsic and intrinsic. While extrinsic eosinophilic disorders are usually due to the production of eosinopoietic factors derived from T cells or tumor cells, the intrinsic types generally are the result of genetic mutations in the eosinophilic lineage. As we understand more the biology of eosinophils, only a few eosinophilic disorders remain idiopathic. The purpose of this article is to help the clinician classify in an operational manner most eosinophilic disorders, using the extrinsic and intrinsic model. This may facilitate not only a better understanding of the role of eosinophils in these disorders, but also help the systematic clinical work-up and potential treatment of affected patients.

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<p>Abdominal Lymphocyte-Depleted Hodgkin Lymphoma: A Rare Presentation</p>

Kasinathan

Kori

Hassan

2019

IJGM

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BackgroundHodgkin lymphoma (HL) is a type of lymphoma that arises from the B lymphocytes. The four main subtypes of HL are the nodular sclerosing, mixed cellularity, lymphocyte rich and the lymphocyte depleted. Nodular sclerosis subtype accounts for majority of all classical HL, whereas lymphocytic depletion type accounts for less than 1%. The main objective of reporting this case is to share with the medical fraternity a rare presentation of abdominal lymphocyte-depleted classical Hodgkin lymphoma.A 47-year-old gentleman of Malay ethnicity with no known pre-morbidities, presented to the haematology unit with a 2-month history of night fever, loss of weight, malaise, anorexia and abdominal swelling. Abdominal examination revealed a periumbilical and lower epigastric swelling measuring 6x6 cms. The swelling was non-tender, firm in consistency and smooth on palpation. The Contrast Enhanced Computed Tomography (CECT) imaging revealed an enlarged mesenteric mass measuring 5.8x6.9x5.7 cm and multiple enlarged aorta-caval lymph nodes. The mesenteric tumour histology and immunohistochemistry were consistent with lymphocyte depleted HL. He completed six cycles of intravenous ABVD polychemotherapy consisting of doxorubicin (Adriamycin) 25mg/m2, Bleomycin 10mg/m2, Vinblastine 6mg/m2 and Dacarbazine 375mg/m2. The Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography (FDG PET /CT) imaging post 2 cycles and 6 cycles of ABVD polychemotherapy showed complete metabolic response to chemotherapy. ConclusionLymphocyte-depleted classical Hodgkin lymphoma (LDcHL) is a rare entity and is mostly diagnosed at a later stage rendering it a disease with poor prognostic outcomes. Early detection and prompt institution of therapy is crucial in the management of this disease.

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Lymphocyte Rich Hodgkin's Lymphoma Presented with Warm Hemolytic Anemia: A Case Report and Literature Review

Cited by 4 publications

References 12 publications

Lymphocyte Depleted Hodgkin’s Lymphoma Presented with Haemolytic Anemia: A Case Report and Literature Review

Lymphocyte Depleted Hodgkin’s Lymphoma Presented with Haemolytic Anemia: A Case Report and Literature Review

Eosinophilic Disorders in Various Diseases

<p>Abdominal Lymphocyte-Depleted Hodgkin Lymphoma: A Rare Presentation</p>

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