Lymphocyte sensitisation in nifedipine-induced hepatitis.

Rotmensch, Heschi H.; Roth, Andreas; Liron, M; Rubinstein, Arye; Gefel, A; Livni, E

doi:10.1136/bmj.281.6246.976-a

Cited by 26 publications

(8 citation statements)

References 4 publications

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“…1982, M Y R -H E D 19851, anddiltiazem (McCRAW 1982). Hepatotoxicity has been recorded in some patients after verapamil (BROD-SKY et al 1981, NASH & FEEH 1983, GUARASCIO et al 1984 as well as after nifedipine (ROTMENCH et al 1980, DA-VIDSON 1980 and hyperprolactinaemiagalactarrhea has been associated with verapamil (FEARRINGTON e t al. 1983).…”

Section: Spectrum Of Side Effectsmentioning

confidence: 99%

Calcium Channel blockers: Spectrum of Side Effects and Drug Interactions

Hedner

1986

Acta Pharmacologica et Toxicologica

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Calcium antagonists are a chemically heterogenous group of agents with potent cardiovascular effects which are beneficial in the treatment of angina pectoris, arterial hypertension and cardiac arrhythmias. The main side effects for the group are dose‐dependent and the result of the main action or actions of the calcium antagonists, i.e. vasodilatation, negative inotropic effects and antiarrhythmic effects. Pronounced hypotension is reported for the main calcium antagonist drugs; verapamil, diltiazem and nifedipine. While conduction disturbances and bradycardia are seen more often after verapamil and diltiazem, tachycardia, headache and flush are more frequent after nifedipine. Constipation is relatively frequent after verapamil while nifedipine is reported to induce diarrhea in som patients. Idiosyncratic side effects are rare but have been reported from the skin, mouth, musculoskeletal system, the liver and the central nervous system. These side effects include urticarial rashes, gingival hyperplasia, arthralgia, hepathotoxicity and transistory mental confusion or akathisia. Verapamil, diltiazem and possibly also nifedipine have been reported to increase serum digoxin concentrations but the clinical relevance of these drug interactions are not clear. Furthermore, verapamil and diltiazem may potentiate the effects of β‐adrenergic blocking drugs and verapamil may also potentiate the effects of neuromuscular blocking drugs. It is concluded that side effects after calcium antagonist drugs are mostly trivial and transient although they may sometimes be relatively common. Clinically relevant drug interactions are few. Judged from the point of efficacy and safety, calcium antagonists will have a major place in the future pharmacotherapy of several cardiovascular disorders.

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Section: Spectrum Of Side Effectsmentioning

confidence: 99%

Calcium Channel blockers: Spectrum of Side Effects and Drug Interactions

Hedner

1986

Acta Pharmacologica et Toxicologica

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“…Nifedipine often provokes orthostatic hypotension, dizziness, flushes, 'headaches, vomiting, and peripheral oedema. Nifedipine has been found to cause hepatitis only in rare cases (Report of the Centrum voor Geneesmiddelenbewaking, 1981 ;Rotmensch et al, 1980). For patients with coronary artery disease, the start of nifedipine treatment may exacerbate anginal crises.…”

Section: Side Effectsmentioning

confidence: 99%

Calcium Antagonists, a New Class of Antihypertensive Agents

Schwartz¹

1988

Fundamemntal Clinical Pharma

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Summary— The mechanism of action of Ca++ antagonists remains debatable. Not all voltage‐sensitive calcium channels have the same sensitivity to organic calcium blockers. Those in smooth muscle are clearly more sensitive than those in heart, and at least some of those in brain are not blocked at all. It is possible that in vascular smooth muscle, calcium antagonists act essentially on receptor‐operated channels. In any case, calcium antagonists are potent antihypertensive agents, but in clinical practice they have limitations. A second generation of dihydropyridines may provide a higher degree of therapeutic selectivity.

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“…References: 1 observations, 1987). The conventional method cultures "a few milliliters" of fluid after the specimen has reached the laboratory.…”

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confidence: 99%