Lymphocyte subpopulations in premature infants: an observational study

Kent, Alison; Scorrer, Tim; Pollard, Andrew J.; Snape, Matthew D.; Clarke, Paul; Few, Karen; Menson, Esse; Varghese, Anu Susan; Hughes, Stephen; Ladhani, Shamez; Heath, Paul T

doi:10.1136/archdischild-2015-309246

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Immune Cell Composition Of Blood Throughout Development1

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Cited by 4 publications

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“…B-cell count and frequency increases up until around 1-2 years of age, followed by a decrease to lower levels in adulthood [94][95][96][97][98] . The CD4:CD8 ratio decreases from birth to adulthood [94][95][96][99][100][101] , and there is a continuous decrease of the ratio between naïve and memory T-cells, both in the CD4+ and CD8+ T-cell lineages 94,95,99,102 .…”

Section: Immune Cell Composition Of Blood Throughout Developmentmentioning

confidence: 99%

The repertoire of maternal anti-viral antibodies in human newborns

Pou

Nkulikiyimfura

Henckel

et al. 2019

Nat Med

112

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Section: Immune Cell Composition Of Blood Throughout Developmentmentioning

confidence: 99%

The repertoire of maternal anti-viral antibodies in human newborns

Pou

Nkulikiyimfura

Henckel

et al. 2019

Nat Med

112

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“…Previous studies on immuno-globulin profile in preterm neonates have documented reduced immunoglobulin concentrations in preterm as compared to term babies. Studies on lymphocyte subsets and immunoglobulins in preterm neonates have had varying results [3][4][5][6][7][8][9][10][11][12][13][14][15]. Literature is scanty regarding immuno-globulin and lymphocyte subsets at very low gestation.…”

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confidence: 99%

Immunoglobulin Profile and Lymphocyte Subsets in Preterm Neonates

et al. 2022

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Objective We documented the immunological profile of neonates and mothers, and lymphocyte subsets at birth. Methods Consecutively born preterm neonates (26 to 31 weeks gestation) at our level III neonatal unit, fulfilling the inclusion criteria were enrolled. Immunoglobulin levels were assessed in maternal blood and in cord blood along with T cell subsets. Results A total of 115 neonates were enrolled. The mean cord levels for IgG, IgM and IgA, respectively were 5.34, 0.10 and 0.04 g/L and of B, T, NK and NK-T cells were 14%, 71%, 10% and 1%, respectively of total lymphocyte population. Cord IgG and IgA levels showed a significantly rising trend with increasing gestation ( P =0.005 and 0.02, respectively) but not IgM and T cell subsets. Maternal immunoglobulins were similar in all gestations. Conclusion The cord IgG and IgA increased with increasing gestation but not IgM in neonates. Electronic Supplementary Material Supplementary material is available in the online version of this article at 10.1007/s13312-022-2470-0.

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