Lymphocyte subset differences in patients with chronic fatigue syndrome, multiple sclerosis and major depression

Robertson, Michael J.; Schacterle, Richard S.; Mackin, Glenn A.; Wilson, Scott; Bloomingdale, Kerry; Ritz, Jérôme; Komaroff, Anthony L.

doi:10.1111/j.1365-2249.2005.02833.x

Cited by 77 publications

(54 citation statements)

References 68 publications

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“…The results of behavioral measures revealed that JPC is comparable to Ginsenoside. Some researcher reported that NK cell activities and CD4 + /CD8 + ratio of CFS patients were decreased (Bansal, Bradley, Bishop, KianiAlikhan, & Ford, 2012;Chen et al, 2009;Robertson et al, 2005). In the present study, the results showed that JPC treatment at the medium and high doses dramatically improved NK cell activities, T cell proliferation, CD4 + /CD8 + ratio and CD4 + counts in CFS rats.…”

Section: Discussionsupporting

confidence: 61%

Immunomodulating and antioxidant effects of polysaccharide conjugates from the fruits of Ziziphus Jujube on Chronic Fatigue Syndrome rats

Chi

Kang

Yan

et al. 2015

Carbohydrate Polymers

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Section: Discussionsupporting

confidence: 61%

Immunomodulating and antioxidant effects of polysaccharide conjugates from the fruits of Ziziphus Jujube on Chronic Fatigue Syndrome rats

Chi

Kang

Yan

et al. 2015

Carbohydrate Polymers

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“…In contrast, Robertson et al (2005) have demonstrated that no increase in either total B cells or CD5+ B cells were present in patients with CFS compared to healthy controls. An increase in the number of CD8+/HLA-DR+ and CD8+/CD38+ T cells have been found in patients with CFS, although the trend was not statistically significant (Robertson et al, 2005). An increase in this class of T cells has also been observed by Klimas et al (1990).…”

Section: Immune Responsementioning

confidence: 73%

Chronic fatigue syndrome

Devanur

Kerr

2006

Journal of Clinical Virology

131

101

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“…The functional state of T-lymphocytes often depends on the percentage distribution of T-lymphocyte subsets, of which CD3 + , CD4 + , and CD8 + T cells predominate. 33 The dynamic balance of CD4 + :CD8 + ratio, usually 1.3~2.1:1, can also indicate the state and capacity of cell-mediated immunity and the host's ability to inhibit tumour growth. 34 Generally, the lower CD4 + :CD8 + ratio after surgery means cell-mediated immunological dysfunction in patients.…”

Section: Discussionmentioning

confidence: 99%

Early immune outcome of retroperitoneal laparoscopic radical nephrectomy for localized renal cell carcinoma: a prospective, randomized study

Yang

Fan

Wei

et al. 2012

CUAJ

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Objectives: We evaluated differences in cytokine responses and T-lymphocyte subsets following retroperitoneal laparoscopic and conventional open radical nephrectomies for localized renal cell carcinoma (RCC). Methods: A total of 62 patients with T 1 N 0 M 0 staged RCC were randomized to either retro-laparoscopic (n = 31) or open (n = 31) radical nephrectomy. Plasma levels of interleukin-1β (IL-1β), IL-6, and tumour necrosis factor-alpha (TNF-α) were measured separately by enzyme linked immunosorbent assay (ELISA) preoperatively and on postoperative days 1 and 5. Levels + in the open group, returned to about preoperative levels (p < 0.05). Follow-up ranged from 4 to 14 months postoperatively in all 62 patients with a 100% cancerspecific survival rate in both groups. Conclusions: Retroperitoneal laparoscopic radical nephrectomy is associated with the milder cytokine responses caused by trauma and inflammation and the better preserved distribution of T-lymphocytes. IntroductionSince Clayman and colleagues in 1991 1 reported the first laparoscopic radical nephrectomy (LRN) for a tumour-bearing kidney, this technique has become increasingly popular because of milder postoperative pain, decreased hospital stay and shortened convalescence compared to the conventional open radical nephrectomy (ORN). During the last 20 years, with advances in instrumentation and surgeon experience, LRN has emerged as an equally effective and minimally morbid surgical alternative to ORN for selected kidney neoplasms. 2,3Surgical trauma provokes a variety of physiologic and immunologic changes in the host. The host's acute phase response to injury includes a complicated interaction among the metabolic, neuroendocrine and immune systems. This response is deemed to be proportional to the extent of the initial injury and is presumably directed toward the host defense. 4 Due to this altered immune response in the postoperative period, surgical trauma can cause an increased production of pro-inflammatory cytokines and an inhibition of cellular responses.5 A wealth of studies with intermediate to long-term follow-up results indicate that laparoscopic radical malignance resections offer equivalent safety and oncologic efficacy as compared to open surgical approaches.6,7 This is partially because of the reduced inflammatory response and minimal extent of immunosuppression. However, some authors have reported no evidence of improved immunity after laparoscopy. [8][9][10][11] In addition, port site metastases (PSM) and local recurrences, although occasionally observed, remain a disputable problem with laparoscopic surgery for cancer. 12,13 With respect to renal cell carcinoma (RCC), laparoscopy related studies on the host immunity are insufficient and incomplete. Whether and how the laparoscopy under CO 2 pneumoperitoneum could exert some negative influences on the RCC patients is still unclear.

show abstract

Lymphocyte subset differences in patients with chronic fatigue syndrome, multiple sclerosis and major depression

Abstract: /CD3-NK cells. Further study will be required to determine whether these alterations in lymphocyte subsets are directly involved in the pathophysiology of these disorders, or are secondary effects of the causal agent(s).

Cited by 77 publications

References 68 publications

Immunomodulating and antioxidant effects of polysaccharide conjugates from the fruits of Ziziphus Jujube on Chronic Fatigue Syndrome rats

Immunomodulating and antioxidant effects of polysaccharide conjugates from the fruits of Ziziphus Jujube on Chronic Fatigue Syndrome rats

Chronic fatigue syndrome

Early immune outcome of retroperitoneal laparoscopic radical nephrectomy for localized renal cell carcinoma: a prospective, randomized study

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