Lymphocyte subset distribution and cytokine secretion in third trimester decidua in normal pregnancy and preeclampsia

Wilczyński, Jacek R.; Tchórzewski, H; Banasik, Mirosław; Głowacka, Ewa; Wieczorek, Artur; Lewkowicz, Przemysław; Malinowski, Andrzej; Szpakowski, M; Wilczyński, J

doi:10.1016/s0301-2115(02)00350-0

Cited by 122 publications

(100 citation statements)

References 34 publications

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“…Increased numbers of CD4+ T lymphocytes have been reported in decidua from women with pre-eclampsia compared to age matched controls (Stallmach et al, 1999;Wilczynski et al, 2003). However, work in our laboratory demonstrated a reduction in both CD3+ and CD8+ cells in pre-eclampsia (Scaife, Innes, Searle, Robson, Bulmer; unpublished data).…”

Section: T Lymphoctyes In Pathological Pregnancymentioning

confidence: 69%

Immune cells in the placental bed

Bulmer¹,

Williams²,

Lash³

2010

Int. J. Dev. Biol.

319

280

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Section: T Lymphoctyes In Pathological Pregnancymentioning

confidence: 69%

Immune cells in the placental bed

Bulmer¹,

Williams²,

Lash³

2010

Int. J. Dev. Biol.

319

280

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“…В этих кластерах присутствуют как CD56 + NK-клетки, так и CD8 + и CD4 + Т-лимфоциты [14]. Несмотря на изме-нения количественного и качественного соста-ва лейкоцитов, представленных в децидуаль-ной ткани, к третьему триместру беременности в децидуальной ткани сохраняется присутствие NK-клеток, CD4 + и CD8 + Т-лимфоцитов [19]. Таким образом, миграция лейкоцитов в дециду-альную ткань может приводить к формированию временных лимфоидных образований в функ-циональном отношении играющих, вероятно, важную роль в материнско-фетальных иммуно-логических взаимоотношениях.…”

Section: Introductionunclassified

“…Снижение продукции этих и других цитокинов влечет за собой наруше-ние баланса цитокиновой сети ткани плаценты, что приводит к развитию таких патологий бере-менности, как гестоз [3]. Кроме того, снижение количества CD4 + Т-лимфоцитов в децидуальной ткани может приводить к нарушению состоя-ния иммунологической толерантности и также способствовать развитию гестоза [19]. Несмо-тря на важную роль CD4 + Т-лимфоцитов в под-держании профиля секретируемых цитокинов в децидуальной ткани и их влияние на другие клетки децидуальной ткани и плаценты, в лите-ратуре недостаточно внимания уделяется функ-циональному состоянию CD4 + Т-лимфоцитов при физиологической беременности и при гесто-зе.…”

Section: Introductionunclassified

Expression of Surface Markers on Cd4+t-Lymphocytes in Normal Pregnancy and Pre-Eclampsia

Михайлова¹,

Onokhina²,

Ovchinnikova³

et al. 2014

Med.Imm.Rus

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“…15 Chakraborty et al 16 showed that in rats, uNK cells are involved in hemochorial placentation by regulating trophoblast cell lineage decisions. Moreover, they presented results showing that endovascular trophoblast cell invasion is increased in wild-type rats during midpregnancy after depletion of uNK cells.…”

mentioning

confidence: 99%

Natural Killer Cell Reduction and Uteroplacental Vasculopathy

et al. 2016

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Abstract-Uterine natural killer cells are important for uteroplacental development and pregnancy maintenance. Their role in pregnancy disorders, such as preeclampsia, is unknown. We reduced the number of natural killer cells by administering rabbit anti-asialo GM1 antiserum in an established rat preeclamptic model (female human angiotensinogen×male human renin) and evaluated the effects at the end of pregnancy (day 21), compared with preeclamptic control rats receiving normal rabbit serum. In 100% of the antiserum-treated, preeclamptic rats (7/7), we observed highly degenerated vessel cross sections in the mesometrial triangle at the end of pregnancy. This maternal uterine vasculopathy was characterized by a total absence of nucleated/living cells in the vessel wall and perivascularly and prominent presence of fibrosis. Furthermore, there were no endovascular trophoblast cells within the vessel lumen. In the control, normal rabbit serum-treated, preeclamptic rats, only 20% (1/5) of the animals displayed such vasculopathy. We confirmed the results in healthy pregnant wild-type rats: after anti-asialo GM1 treatment, 67% of maternal rats displayed vasculopathy at the end of pregnancy compared with 0% in rabbit serum-treated control rats. This vasculopathy was associated with a significantly lower fetal weight in wild-type rats and deterioration of fetal brain/liver weight ratio in preeclamptic rats. Anti-asialo GM1 application had no influence on maternal hypertension and albuminuria during pregnancy. Our results show a new role of natural killer cells during hypertensive pregnancy in maintaining vascular integrity. In normotensive pregnancy, this integrity seems important for fetal growth. (Hypertension. 2016;68:964-973.

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Lymphocyte subset distribution and cytokine secretion in third trimester decidua in normal pregnancy and preeclampsia

Cited by 122 publications

References 34 publications

Immune cells in the placental bed

Immune cells in the placental bed

Expression of Surface Markers on Cd4+t-Lymphocytes in Normal Pregnancy and Pre-Eclampsia

Natural Killer Cell Reduction and Uteroplacental Vasculopathy

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