1992
DOI: 10.1111/j.1365-2249.1992.tb02999.x
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Lymphocyte subsets and β2-microglobulin expression in chronic hepatitis C/non-A, non-B. Effects of interferon-alpha treatment

Abstract: SUMMARYThirty-three patients with chronic hepatitis C/non-A. non-B were included in a randomized controlled study of interferon-alpha 2b (1FN-O(2b) treatment. 3 x 10'' LJ three times weekly for 36 weeks. Using an immunoperoxidase technique, frozen liver biopsy specimens were examined with MoAbs for the presence ofT helper cells (CD4). T suppressor/cytotoxic cells (CD8), total T cells (CD2) and B cells (CD22) before and after treatment. /J:-microglobulin (//rMG) expression on hepatocytes was semiquantified usin… Show more

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Cited by 20 publications
(6 citation statements)
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“…Indeed, our results also indicated that both CD4 * and CD8' T cells could express the same array of cytokines under PMA and PHA activation, although differences in magnitude and time-course were demonstrated for individual cytokines. Our data also revealed that Abnormalilics in T cell activation and cytokine release have been reported in vnrious pathological conditions (23)(24)(25)(26)(27)(28)(29). Since the majority of these studies involved the use of mixed population of cells (mainly PBMC) with different siimuli.…”
Section: Discussionsupporting
confidence: 62%
“…Indeed, our results also indicated that both CD4 * and CD8' T cells could express the same array of cytokines under PMA and PHA activation, although differences in magnitude and time-course were demonstrated for individual cytokines. Our data also revealed that Abnormalilics in T cell activation and cytokine release have been reported in vnrious pathological conditions (23)(24)(25)(26)(27)(28)(29). Since the majority of these studies involved the use of mixed population of cells (mainly PBMC) with different siimuli.…”
Section: Discussionsupporting
confidence: 62%
“…This capability could be of physiological relevance, even though the mechanism of their secretion remains to be elucidated. During several diseases their secretion is significantly modified [13][14][15][16][17][18][19][20], The present study demonstrates for the first time that serum levels of sCD4, sCD8 and /^j-M are significantly increased In the sera of patients with acute VL compared with healthy controls. The different profiles of secretion of these soluble products suggest that T ceil subsets are strongly activated, but at difFerent times and not all together.…”
Section: Discussionsupporting
confidence: 53%
“…Therefore, there could be in some way a relation between the clearing of infection by CD8"^ cells and the disappearance of eirculating sCD8. The increase of di-M release in the acute phase of the disease, as observed in other diseases [14,19,20], is a further index ofTcell activation and of active cell turnover in this infection. The pattern of raised serum levels of/32-M in the acute phase of the disease was similar to that of sCD8, and we did observe a significant direct correlation between the two parameters (r = 0 900.…”
Section: Discussionmentioning
confidence: 82%
“…The b2MG production by hepatocytes is associated with chronic inflammation correlated to viral hepatitis (hepatitis B and C virus) [116]. HCC cells show a higher expression of class I HLA antigens than normal hepatocytes, so tumor cells avoid immunological response [117,118].…”
Section: Serum Proteomicsmentioning
confidence: 99%