Lymphocyte subsets in human encephalitic and paralytic rabies

Sriwanthana, Busarawan; Hemachudha, Thiravat; Griffin, D. E.; Manutsathit, Sathaporn; Tweardy, David J.; Phanuphak, Praphan

doi:10.1111/j.1600-0404.1989.tb03880.x

Cited by 13 publications

(5 citation statements)

References 9 publications

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“…We have shown that some paralytic rabies patients may lack the ability to produce antibody as evidenced by diminished circulating B cells and IL-6 levels. Fewer paralytic rabies patients had rabies-neutralizing antibody in the sera [14,42].…”

Section: Discussionmentioning

confidence: 99%

Difference in neuropathogenetic mechanisms in human furious and paralytic rabies

Mitrabhakdi

Shuangshoti

Wannakrairot

et al. 2005

Journal of the Neurological Sciences

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Section: Discussionmentioning

confidence: 99%

Difference in neuropathogenetic mechanisms in human furious and paralytic rabies

Mitrabhakdi

Shuangshoti

Wannakrairot

et al. 2005

Journal of the Neurological Sciences

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“…Mainly in MS, the distribution of leukocyte subsets both in the cerebrospinal fluid (CSF) and in the peripheral blood (PB) has been widely investigated with monoclonal antibodies, (2)(3)(4)(5)(6), while, as pointed out by McFarlin (7), to date relatively few studies have been focused on CNS I D (8)(9)(10)(11)(12), nor on the two diseases simultaneously (13,14).…”

mentioning

confidence: 99%

Natural killer cells and lymphocyte subsets in active MS and acute inflammation of the CNS

Merelli

Sola

Faglioni

et al. 1991

Acta Neurologica Scandinavica

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Cerebrospinal fluid (CSF) and peripheral blood (PB) lymphocyte subsets were determined by flow cytometry (FCM) in 15 patients with active multiple sclerosis (MS) and 15 patients with acute inflammatory diseases (ID) of the central nervous system (CNS) in order to establish correlations between the two groups of diseases, as well as between the CSF and PB subsets distribution. A panel of monoclonal antibodies was applied to all the samples: Leu3 (CD4), Leu4 (CD3), Leu2 (CD8), Anti-HLA-DR, Leu11 (CD16). Statistical analysis did not show differences in CD3+ nor in CD3+ DR+ T-cells both in the CSF and PB in the two groups of patients. CD4+ cells were significantly higher in the CSF than in the PB, while CD8+, DR+ CD3- and CD16+ cells were constantly lower in the CSF without differences between the two groups of diseases.

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“…Evidence of cellmediated immunity, by lymphocyte transformation tests, was found in six of nine furious encephalitis patients, but not in seven with paralytic disease (Hemachudha et al 1988), who had few B cells. Both groups had reduced NK cell levels (Sriwanthana et al 1989). …”

Section: Immunologymentioning

confidence: 99%

Rabies Encephalitis and its Prophylaxis

Warrell

2001

Pract Neurol

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INTRODUCTION It is possible to provide very efficient prophylaxis against rabies encephalitis, which remains universally fatal in practice. The unique pathogenisis of this neurotropic virus is slowly being unravelled, but the relevance of the paradoxical immunological features remain mysterious. The epidemiology of rabies is being clarified because virus strains can now be classified and identified precisely. Recent developments are reviewed here; also a clinician’s view of rabies, its diagnosis, and of the patients said to have recovered from rabies encephalitis. Rabies is a zoonosis of certain mammal species, endemic in all continents. Only a few European countries, some islands and peninsulas and Antarctica, are free of the fear of rabies, although imported infection is a universal risk. Rabies occurs in separate cycles within dogs and wild mammal vector species (see ‘Post-exposure treatment’, page 24), and the virus sometimes spills over to nonvector species such as humans. Strains of virus from

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Lymphocyte subsets in human encephalitic and paralytic rabies

Cited by 13 publications

References 9 publications

Difference in neuropathogenetic mechanisms in human furious and paralytic rabies

Difference in neuropathogenetic mechanisms in human furious and paralytic rabies

Natural killer cells and lymphocyte subsets in active MS and acute inflammation of the CNS

Rabies Encephalitis and its Prophylaxis

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