Lymphocyte subsets in women on low dose oral contraceptives

Baker, David A.; Hameed, Chaudhry; Tejani, Nergesh; Milch, Peter O.; Thomas, J; Monheit, Alan G.; Dattwyler, Raymond J.

doi:10.1016/0010-7824(85)90041-1

Cited by 30 publications

(3 citation statements)

References 9 publications

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“…One other interesting observation in this study was the higher use of birth control pills by the left frontal group. However, this could not have accounted for our findings because most recent studies have found very little or no effect of birth control pills on immune responses (Baker et al, 1985; Bisset & Griffin, 1988a, 1988b). Indeed, it would have worked against our findings because the only significant effects on NK responses have been that pill use may decrease lytic activity slightly (Baker, Salvatore, & Milch, 1989).…”

Section: Discussionmentioning

confidence: 71%

Frontal brain asymmetry and immune function.

Kang¹,

Davidson²,

Coe³

et al. 1991

Behavioral Neuroscience

122

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The relation between brain activity and the immune system was evaluated by assessing immune responses in 20 healthy women who manifested extreme differences in the asymmetry of frontal cortex activation. One group showed extreme and stable left frontal activation; the other group showed extreme and stable right frontal activation. As predicted, women with extreme right frontal activation had significantly lower levels of natural killer cell activity (at effector:target cell ratios of 33:1 and 11:1) than did left frontally activated individuals. This difference did not extend to two other immune measures, lymphocyte proliferation and T-cell subsets. However, higher immunoglobulin levels of the M class were observed in the right frontal group. In this study, the immune patterns could not be accounted for by plasma cortisol levels, anxietyand depression-related symptomatology, or recent health histories. These findings support the hypothesis that there is a specific association between frontal brain asymmetry and certain immune responses. Growing interest in the field of psychoneuroimmunology over the last 2 decades has led many investigators to examine the influence of psychological and environmental events on immune responses. It is now known that a variety of stressful events can induce specific alterations in immune responses. For example, divorce, bereavement after loss of a spouse, and psychiatric illness have been shown to be associated with decreased lymphocyte proliferation responses and lower natural killer cell (NK) activity (

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Section: Discussionmentioning

confidence: 71%

Frontal brain asymmetry and immune function.

Kang¹,

Davidson²,

Coe³

et al. 1991

Behavioral Neuroscience

122

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show abstract

“…Recently, emerging evidence has confirmed the encouraging anti-tumor effect of Met [ 6-8 ]. Furthermore, its long-term application attenuates the risk of multiple types of malignancies [ 9 ]. In lung cancer, several retrospective cohort studies revealed that Met application could reduce the risk of developing lung cancer and improve the prognosis of lung cancer patients [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

Metformin suppresses lung adenocarcinoma by downregulating long non-coding RNA (lncRNA) AFAP1-AS1 and secreted phosphoprotein 1 (SPP1) while upregulating miR-3163

Qiu

Zheng

et al. 2022

Bioengineered

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AFAP1-AS1 plays a pro-tumor role in lung cancer. However, no investigation has focused on whether it is involved in the anticancer activity of metformin (Met) in the treatment of lung adenocarcinoma (LUAD). Reverse transcription quantitative polymerase chain reaction (RT-qPCR) was performed to detect the expression of long non-coding (lnc)RNA AFAP1-AS1, the microRNA (miR)-3163, and secreted phosphoprotein 1 (SPP1) in LUAD tissues, or of A549 and H3122 cells. Cell Counting Kit-8, wound scratch, and cell invasion assays were performed to evaluate the effect of the overexpression of lncRNA AFAP1-AS1, miR-3163, and SPP1 on the malignant behaviors of A549 and H3122 cells. Phosphatidylinositol 3-kinase/protein kinase B/mammalian target of rapamycin (PI3K/Akt/mTOR) signaling pathway-related proteins were detected by Western blot analysis. Dual luciferase reporter or RIP assays were used to determine the interplay between AFAP1-AS1 and miR-3163, or of miR-3163 and SPP1. Met inhibits the malignant characteristics of A549 and H3122 cells in vitro . GEPIA database analysis showed that AFAP1-AS1 is a highly expressed lncRNA in LUAD tissues, which was validated by RT-qPCR. Overexpression of AFAP1-AS1 suppressed the met-mediated anti-tumor activity in A549 and H3122 cells, while AFAP1-AS1 silencing promoted it. Met inhibited AFAP1-AS1 expression, which resulted in reduced proliferation, migration, and invasion in A549 and H3122 cells. This led to AFAP1-AS1-mediated suppression of miR-3163 and, subsequently, the upregulation of SPP1. Met exerts its antitumor activities by regulating the AFAP1-AS1/miR-3163/SPP1/PI3K/Akt/mTOR axis. Our findings deepen our understanding of mechanisms underlying anti-tumor effect of Met in LUAD.

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“…14 Baker and associates were unable to elicit an alteration in the immune response by measuring various immunological parameters. 15 Since individuals on oral contraceptives have an alteration in their carbohydrate metabolism, this may predispose them to increased risk of urinary tract infections and vaginal infections. Although this has been postulated, it has not been extensively studied using appropriate controls.…”

Section: Generalmentioning

confidence: 99%

The Interrelationship Between Oral Contraceptives and Infections of the Female Reproductive Tract

Spence¹

1989

Semin Reprod Med

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Lymphocyte subsets in women on low dose oral contraceptives

Cited by 30 publications

References 9 publications

Frontal brain asymmetry and immune function.

Frontal brain asymmetry and immune function.

Metformin suppresses lung adenocarcinoma by downregulating long non-coding RNA (lncRNA) AFAP1-AS1 and secreted phosphoprotein 1 (SPP1) while upregulating miR-3163

The Interrelationship Between Oral Contraceptives and Infections of the Female Reproductive Tract

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