Lymphocyte-to-C-reactive Protein Ratio: a New Biomarker to Predict Perforation in Acute Appendicitis

Ugurlu, Celil; Yıldırım, Murat; Öztürk, Alpaslan; Ozcan, Ozhan; Bostan, Mustafa Sami; Yilmaz, S

doi:10.1007/s12262-021-02937-5

Cited by 3 publications

(3 citation statements)

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“…A high neutrophil count and lymphopenia are among the common ones (Carpio-Orantes et al, 2020). the neutrophil/lymphocyte ratio (NLR), platelet (PLT)/lymphocyte ratio (PLR), and mean platelet volume (MPV)/PLT ratios in peripheral blood are reported to be the indicators of the infection type and prognosis (Ugurlu et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

“…a Data were analyzed using the Chi-squared test; b data were analyzed using ANOVA; c data were analyzed using Games-Howell post-hoc multiple comparison tests; d data were analyzed using Tukey's post-hoc multiple comparison tests. NLR, neutrophil/lymphocyte ratio; LCR, lymphocyte/C-reactive protein ratio; CRP, C-reactive protein; MPV, mean platelet volume; PLT, platelet.type of infection and prognosis (Carpio-Orantes et al, 2020;Ugurlu et al, 2021;Bal et al, 2021). The prognostic significance of LCR and NLR has also been reported in acute conditions other than COVID-19 (such as acute appendicitis and acute thyroiditis)(Ugurlu et al, 2021;Aktas et al, 2017) and in intensive care patients(Salciccioli et al, 2015;Wang et al, 2017).…”

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confidence: 99%

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Diagnostic and prognostic significance of the lymphocyte/C-reactive protein ratio, neutrophil/lymphocyte ratio, and D-dimer values in patients with COVID-19

Öztürk¹,

Kara²

2022

Biocell

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In this study, our aim was to examine the diagnostic and prognostic significance of lymphocyte/C-reactive protein ratio (LCR), neutrophil/lymphocyte ratio (NLR) and D-dimer parameters in COVID-19 infection. The LCR, NLR, neutrophil count, mean platelet volume (MPV), C-reactive protein (CRP), and D-dimer parameters were evaluated retrospectively. This was a retrospective cohort study with 1000 COVID-19 positive and 1000 healthy control groups, all over the age of 18 years. Odds ratio (OR) and 95% confidence interval (CI) values were calculated for each parameter found to be statistically significant in the univariate and multivariate logistic regression models.Herein, 127 (12.7%) of the COVID-19 + patients, whose data was included in this study, died. The neutrophil, MPV, CRP, D-dimer, and NLR values were higher in the COVID-19 + /deceased group than in the COVID-19 + /alive and control groups (p < 0.001, p < 0.001, p < 0.001, p < 0.001, p < 0.001). The lymphocyte and LCR values were lower in the COVID-19 + /deceased group than in the COVID-19 + /alive and control groups (p < 0.001, p < 0.001). Variables with statistically significance in predicting COVID-19 infection were lymphocyte, LCR, D-dimer, NLR, CRP, MPV, PLT, and neutrophil values. Statistically significant variables in predicting mortality due to COVID-19 were LCR, CRP, NLR, lymphocyte, D-dimer, neutrophil, and MPV values. A low LCR and high NLR are associated with the presence, prognosis, and mortality due to COVID-19. LCR and NLR parameters can thus be used in clinical monitoring to reduce morbidity and mortality rates.

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confidence: 99%

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confidence: 99%

Diagnostic and prognostic significance of the lymphocyte/C-reactive protein ratio, neutrophil/lymphocyte ratio, and D-dimer values in patients with COVID-19

Öztürk¹,

Kara²

2022

Biocell

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“…There are many diagnostic methods and biochemical indicators in SIH, such as C-reactive protein (CRP), neutrophil-lymphocyte ratio (NLR), and lymphocyte-CRP ratio. [5][6][7] However, most of them were from studies in adults, and the diagnostic value in children, especially in infants, remains unclear. Therefore, we conducted this retrospective study to explore a nomogram for estimating intestinal necrosis in infants under 6 months of age with IIH to assess the severity of the disease and thus more rationally arrange the treatment process.…”

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confidence: 99%

Nomogram for the Estimation of Intestinal Necrosis Risk in Incarcerated Inguinal Hernia in Infants under 6 Months

et al. 2022

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Objective This article develops a nomogram to estimate intestinal necrosis risk in the incarcerated inguinal hernia (IIH) in infants under 6 months. Methods A total of 273 infants who underwent an emergency operation due to IIH were investigated retrospectively. Univariate and multivariate logistic regression were used to analyze the relationship between variables and intestinal necrosis and construct a nomogram of intestinal necrosis. The discrimination and concordance of the model were verified by receiver operating characteristic (ROC) analysis and calibration curve, and the bootstrap method was used for internal validation of the model. The clinical applicability of the model was evaluated using the decision curve and the clinical impact curve. Results Intestinal necrosis was found in 37 of 273 infants (13.6%) in this study. The vomiting symptoms, platelet count, C-reactive protein, and neutrophil-lymphocyte ratio were independent risk factors for intestinal necrosis in IIH. We then constructed a nomogram with these four factors. ROC analysis showed that the nomogram had a good diagnostic performance, with the area under the curve (AUC), sensitivity, and specificity of 0.918 (95% confidence interval: 0.880–0.956), 97.3%, and 69.9%, respectively. The nomogram was further validated using 2,000-repetition internal bootstrap validation, and the values of AUC, sensitivity, and specificity were 0.899, 95.7%, and 50.5%, respectively. The decision curve and the clinical impact curve indicated that the predictive model has a favorable clinical application. Conclusion The nomogram can be used to predict intestinal necrosis in IIH, and allow us to estimate the severity of IIH more accurately and arrange the treatment process more reasonably.

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An Investigation of the Usability of Complete Blood Count Parameters in the Diagnosis of Acute Appendicitis

BAŞER>¹,

Şahin

KARAAĞAÇ>

2022

Turkish Journal of Health Science and Life

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Introduction and Objective: Acute appendicitis is one of the most commonly diagnosed diseases in emergency departments, and it is the abdominal pathology that most frequently requires surgery. The purpose of this study was to investigate the value in the diagnosis of acute appendicitis of routinely investigated complete blood count parameters in patients presenting to the emergency department with abdominal pain. Material and method: This study was planned as a retrospective cohort among patients over 18 years who were diagnosed with acute appendicitis in the tertiary emergency department in Türkiye between January 1 and December 31, 2019. Healthy volunteers aged over 18 with no active complaints undergoing routine blood tests for health screening were included in the control group. Both groups’ records were retrieved retrospectively from the hospital database. Data consisting of the groups’ demographic characteristics at the time of presentation to the emergency department and parameters obtained from complete blood tests were analyzed. Results: A total of 1200 people were included in the study, 600 of which were in the control group. Men constituted 388 (64.7%) of the acute appendicitis patients and 380 (63.3%) of the control group(p=0.674). Leukocyte, neutrophil, nucleated red blood cell, neutrophil-lymphocyte ratio, and platelet-lymphocyte ratio values were significantly higher in the acute appendicitis group compared to the control group(p

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Lymphocyte-to-C-reactive Protein Ratio: a New Biomarker to Predict Perforation in Acute Appendicitis

Cited by 3 publications

References 25 publications

Diagnostic and prognostic significance of the lymphocyte/C-reactive protein ratio, neutrophil/lymphocyte ratio, and D-dimer values in patients with COVID-19

Diagnostic and prognostic significance of the lymphocyte/C-reactive protein ratio, neutrophil/lymphocyte ratio, and D-dimer values in patients with COVID-19

Nomogram for the Estimation of Intestinal Necrosis Risk in Incarcerated Inguinal Hernia in Infants under 6 Months

An Investigation of the Usability of Complete Blood Count Parameters in the Diagnosis of Acute Appendicitis

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