Lymphocyte‐to‐monocyte ratio combined with CA19‐9 for predicting postoperative recurrence of colorectal cancer in patients with diabetes

Yu, Dan; An, Guangyu; Yao, Jiannan

doi:10.1002/jcla.23944

Cited by 5 publications

(4 citation statements)

References 37 publications

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“…Moreover, the role of these indicators on diagnosis and treatment effects in BC was explored. Our observations on NLR, LMR, and PLR are consistent with the research on multiple cancer types, including BC, in recent years ( 15 , 16 , 27 – 34 ).…”

Section: Discussionsupporting

confidence: 92%

Prognostic Evaluation of Metastasis-Related Lymphocyte/Monocyte Ratio in Stage Ⅰ-Ⅲ Breast Cancer Receiving Chemotherapy

et al. 2022

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PurposeThis study aims to clarify the prognostic significance of metastasis-related indicators in peripheral blood in stage I-III breast cancer (BC).MethodsThe clinicopathological data of 938 breast cancer patients and 509 benign breast disease patients were retrospectively analyzed, and fasting blood samples were collected before treatment. Univariate and multivariate regression analyses were used to evaluate factors related to metastasis risk and prognosis. The Kaplan-Meier method was used to generate survival curves, and the log-rank test was used to measure differences in survival between groups.ResultsUse the cut-off value (3.433) of LMR, the logistic regression analysis revealed that high carbohydrate antigen 153 (CA153), carbohydrate antigen 125 (CA125), carcinoembryonic antigen (CEA), killer T cell level, and low lymphocyte to monocyte ratio (LMR) level were significantly associated with BC distant metastasis. In contrast, LMR>=3.433 (HR: 0.409, 95%CI: 0.193–0.867, P = 0.020), Th/Tc ratio >=1.946 (HR: 0.378, 95% CI: 0.158–0.904, P =0.029) is regarded as a protective factor in the multivariate cox analyses. LMR is an independent prognostic factor for DFS in HER2-negative BC patients.ConclusionPeripheral blood parameters play an important role in predicting distant metastasis and prognosis of BC patients. As a potential marker, LMR can predict the metastasis and prognosis of patients with stage I-III BC.

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Section: Discussionsupporting

confidence: 92%

Prognostic Evaluation of Metastasis-Related Lymphocyte/Monocyte Ratio in Stage Ⅰ-Ⅲ Breast Cancer Receiving Chemotherapy

et al. 2022

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“…The following is known about the combined relationship of CRC, CBC ratios, and comorbidities. Lower body mass index and marginally less obese patients can be found with a preoperative PLR > 160[ 53 ], NLR of patients with T2DM or hypertension do not differ from those without the two conditions[ 54 ], LMR combined with carbohydrate antigen 19-9 has good predictive value on postoperative recurrence in CRC + T2DM patients[ 55 ], and PLR is significantly higher in CRC patients with metabolic syndrome[ 56 ]. Furthermore, colorectal adenoma, which has a high risk to develop into CRC[ 57 ], has an increased prevalence in metabolic syndrome patients with higher NLR values[ 23 ], and higher NLR at the diagnosis of CRC may be a sign of stroke within 2 years after cancer diagnosis[ 58 ].…”

Section: Discussionmentioning

confidence: 99%

Longitudinal changes in personalized platelet count metrics are good indicators of initial 3-year outcome in colorectal cancer

Herold¹,

Herold²,

Lohinszky³

et al. 2022

WJCC

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BACKGROUND Platelet count or complete blood count (CBC)-based ratios including lymphocyte-to-monocyte (LMR), neutrophil-to-lymphocyte (NLR), hemoglobin-to-platelet (HPR), red blood cell count distribution width-to-platelet (RPR), and platelet-to-lymphocyte (PLR) ratio are good predictors of colorectal cancer (CRC) survival. Their change in time is not well documented, however. AIM To investigate the effect of longitudinal CBC ratio changes on CRC survival and their possible associations with clinicopathological properties, comorbidities, and anamnestic data. METHODS A retrospective longitudinal observational study was conducted with the inclusion of 835 CRC patients, who attended at Semmelweis University, Budapest. CBC ratios and two additional newly defined personalized platelet count metrics (pPLT D and pPLT S , the platelet counts relative to the measurement at the time of CRC diagnosis and to the one 4-6 wk after tumor removal surgery, respectively) were recorded. RESULTS The 835 CRC patients had a total of 4608 measurements (5.52 visits/patient, in average). Longitudinal survival models revealed that the increases/decreases in LMR [hazard ratio (HR): 0.4989, P < 0.0001], NLR (HR: 1.0819, P < 0.0001), HPR (HR: 0.0533, P = 0.0038), pPLT D (HR: 4.9229, P < 0.0001), and pPLT S (HR: 4.7568, P < 0.0001) values were poor prognostic signs of disease-specific survival. The same was obtained for all-cause mortality. Most abnormal changes occurred within the first 3 years after the diagnosis of CRC. RPR and PLR had an only marginal effect on disease-specific ( P = 0.0675) and all-cause mortality (Bayesian 95% credible interval: 0.90–186.05), respectively. CONCLUSION LMR, NLR, and HPR are good metrics to follow the prognosis of the disease. pPLT D and pPLT S perform just as well as the former, while the use of RPR and PLR with the course of the disease is not recommended. Early detection of the abnormal changes in pPLT D , pPLT S , LMR, NLR, or HPR may alert the practicing oncologist for further therapy decisions in a timely manner.

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“…Carcinoembryonic antigen (CEA) and carbohydrate antigen 19 − 9 (CA19-9) are well-established tumor markers that are present at elevated levels in the serum of patients with various gastrointestinal tumors or in cases where tumor metastasis has already occurred [20,21] . Although CEA and CA19-9 can be used to monitor CRC patients, abnormal changes may also occur in colorectal polyps, indicating that these markers lack speci city and sensitivity [22,23] . Tumor Protein p53 (TP53) is the most commonly mutated gene in humans with CRC [24] .…”

Section: Introductionmentioning

confidence: 99%

Prognostic value of the preoperative prognostic nutritional and systemic immunoinflammatory indexes in patients with colorectal cancer

Li,

Sun,

et al. 2024

Preprint

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Background Colorectal cancer (CRC) is a common malignant tumor of the digestive tract. Although many prognostic indicators are currently available, it remains unclear which indicators are the most beneficial for patients with CRC. Therefore, there is a critical need to identify a simple, convenient and accurate prognostic indicator. Purpose To investigate the clinical significance of the systemic immune-inflammation index (SII) and prognostic nutritional index (PNI) as prognostic indicators for the survival of patients with CRC. Methods The clinical data of CRC patients admitted to the general surgery ward of Taizhou People's Hospital affiliated to Nanjing Medical University from January 2015 to January 2018 were retrospectively analyzed. Two prognostic indicators (SII and PNI) were compared to evaluate their prognostic value in CRC patients. Results Based on these variables, we constructed a LASSO prediction model. The AUC value and 95% CI of the training group were 0.917 (0.858–0.976) compared to 0.932 (0.846–1.000) in the validation group. We found that CEA > 5 ng/mL, tumor stage, pathological type, postoperative complications, and PNI were associated with the five-year survival rate of CRC patients. Receiver Operating Characteristic Curves (ROC) were drawn to assess the prediction accuracy of the model. The AUC and 95% CI of the training group were 0.913 (0.854–0.972), while the AUC and 95% CI of the validation group were 0.954 (0.899–1.000). Conclusions PNI is an independent risk factor for postoperative complications associated with CRC and a powerful tool for predicting survival outcomes in CRC patients.

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Lymphocyte‐to‐monocyte ratio combined with CA19‐9 for predicting postoperative recurrence of colorectal cancer in patients with diabetes

Cited by 5 publications

References 37 publications

Prognostic Evaluation of Metastasis-Related Lymphocyte/Monocyte Ratio in Stage Ⅰ-Ⅲ Breast Cancer Receiving Chemotherapy

Prognostic Evaluation of Metastasis-Related Lymphocyte/Monocyte Ratio in Stage Ⅰ-Ⅲ Breast Cancer Receiving Chemotherapy

Longitudinal changes in personalized platelet count metrics are good indicators of initial 3-year outcome in colorectal cancer

Prognostic value of the preoperative prognostic nutritional and systemic immunoinflammatory indexes in patients with colorectal cancer

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