Lymphocyte-to-monocyte ratio predicts mortality in cirrhotic patients with septic shock

Hsu, Yin-Chou; Yang, Yong-Ye; Tsai, I‐Ting

doi:10.1016/j.ajem.2020.11.071

Cited by 14 publications

(7 citation statements)

References 34 publications

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“…Zhu and Zhou [42] documented NLR ability to distinguish LC from healthy controls, but could not discriminate cirrhotic HCC from LC. Also, LMR was suggested to be useful to determine the outcome of cirrhotic patients by Hsu et al [43]. In contrast, Du et al [44] found that elevated NLR is associated with HCC development in cirrhotic patients with HBV who underwent splenectomy for hypersplenism.…”

Section: Discussionmentioning

confidence: 99%

Monocytes Subsets Altered Distribution and Dysregulated Plasma hsa-miR-21-5p and hsa- miR-155-5p in HCV-Linked Liver Cirrhosis Progression to Hepatocellular Carcinoma

Hammad

Dosoky

Madbouly

et al. 2023

Preprint

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Cirrhosis-associated immune dysfunction (CAID) is an immunological perturbation that develops on top of liver cirrhosis (LC). Immune perturbation directs LC progression to hepatocellular carcinoma (HCC). Innate immune cells, in particular, monocytes, play key roles in inflammation and tumorigenesis. MicroRNAs (miRs) have been regarded as master regulators of the immune networks. We aim to investigate the altered monocytes subsets distribution in LC and subsequent HCC in association with the expression level of plasma homo sapiens (hsa)-miR-21-5p and hsa-miR-155-5p. A step toward non-protein coding (nc) RNA precision medicine based on the immune perturbation, manifested as altered monocytes distribution, on top of LC and HCC. Subjects and Methods: Seventy-nine patients diagnosed with chronic hepatitis C virus (CHCV) infection with LC were enrolled in the current study. Patients were sub-classified into LC group without HCC (n=40), LC with HCC (n=39), and 15 apparently healthy controls. Monocyte subsets frequencies were assessed by flow-cytometry. Real-time quantitative PCR was used to measure plasma hsa-miR-21-5p and hsa-miR-155-5p expression. Results: hsa-miR-21-5p correlated with intermediate monocytes (r=0.30, p=0.007), while hsa-miR-155-5p negatively correlated with nonclassical monocytes (r= -0.316, p=0.005). ROC curve analysis revealed that combining intermediate monocytes frequency and hsa-miR-21 yielded sensitivity= 79.5%, specificity= 75%, and AUC= 0.84. In comparison, AFP yielded a lower sensitivity = 69% and 100% specificity with AUC= 0.85. Logistic regression analysis proved that up-regulation of intermediate monocytes frequency and hsa-miR-21-5p were independent risk factors for LC progression to HCC, after adjustment for co-founders. Conclusion: Monocyte subsets differentiation in HCC was linked to hsa-miR-21-5p and hsa-miR-155-5p. Combined up-regulation of intermediate monocytes frequency and hsa-miR-21-5p expression could be considered a sensitive indicator of LC development to HCC. Circulating intermediate monocytes and hsa-miR-21-5p were independent risk factors for HCC evolution, clinically and in silicoproofed.

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Section: Discussionmentioning

confidence: 99%

Monocytes Subsets Altered Distribution and Dysregulated Plasma hsa-miR-21-5p and hsa- miR-155-5p in HCV-Linked Liver Cirrhosis Progression to Hepatocellular Carcinoma

Hammad

Dosoky

Madbouly

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…Zhu and Zhou ( 2022 ) documented NLR ability to distinguish LC from healthy controls but could not discriminate cirrhotic HCC from LC. In addition, LMR was suggested to be useful to determine the outcome of cirrhotic patients by Hsu et al ( 2021 ). In contrast, Du et al ( 2018 ) found that elevated NLR is associated with HCC development in cirrhotic patients with HBV who underwent splenectomy for hypersplenism.…”

Section: Discussionmentioning

confidence: 99%

Monocytes subsets altered distribution and dysregulated plasma hsa-miR-21-5p and hsa-miR-155-5p in HCV-linked liver cirrhosis progression to hepatocellular carcinoma

Hammad,

Eldosoky,

Elmadbouly

et al. 2023

J Cancer Res Clin Oncol

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Purpose The authors aim to investigate the altered monocytes subsets distribution in liver cirrhosis (LC) and subsequent hepatocellular carcinoma (HCC) in association with the expression level of plasma Homo sapiens (has)-miR-21-5p and hsa-miR-155-5p. A step toward non-protein coding (nc) RNA precision medicine based on the immune perturbation manifested as altered monocytes distribution, on top of LC and HCC. Methods Seventy-nine patients diagnosed with chronic hepatitis C virus (CHCV) infection with LC were enrolled in the current study. Patients were sub-classified into LC group without HCC (n = 40), LC with HCC (n = 39), and 15 apparently healthy controls. Monocyte subsets frequencies were assessed by flow cytometry. Real-time quantitative PCR was used to measure plasma hsa-miR-21-5p and hsa-miR-155-5p expression. Results Hsa-miR-21-5p correlated with intermediate monocytes (r = 0.30, p = 0.007), while hsa-miR-155-5p negatively correlated with non-classical monocytes (r = − 0.316, p = 0.005). ROC curve analysis revealed that combining intermediate monocytes frequency and hsa-miR-21 yielded sensitivity = 79.5%, specificity = 75%, and AUC = 0.84. In comparison, AFP yielded a lower sensitivity = 69% and 100% specificity with AUC = 0.85. Logistic regression analysis proved that up-regulation of intermediate monocytes frequency and hsa-miR-21-5p were independent risk factors for LC progression to HCC, after adjustment for co-founders. Conclusion Monocyte subsets differentiation in HCC was linked to hsa-miR-21-5p and hsa-miR-155-5p. Combined up-regulation of intermediate monocytes frequency and hsa-miR-21-5p expression could be considered a sensitive indicator of LC progression to HCC. Circulating intermediate monocytes and hsa-miR-21-5p were independent risk factors for HCC evolution, clinically and in silico proved. Graphical abstract

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“…However, apoptosis of neutrophils and lymphocytes increases gradually during sepsis, which affects the NLR as a result. [6] Therefore, the predictive capability of the NLR might vary in sepsis. Then, data showed that the AUC of the NLR in the SAPS3 ≤52 group was significantly higher than that in the SAPS3 >52 group.…”

Section: Figurementioning

confidence: 99%

The Influencing Factors of Neutrophil-to-Lymphocyte Ratio as a Prognostic Marker for Sepsis: Analysis from a Large Database

Zhao,

Ma,

Xiao

et al. 2023

Infect Dis Immun

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The neutrophil-to-lymphocyte ratio (NLR) is an important predictive prognostic tool. However, its accuracy for predicting sepsis remains debatable. This study aimed to evaluate the factors influencing the ability of NLR to predict sepsis. Adult patients with sepsis or septic shock from the eICU database were enrolled in this study. Results showed that there was a significant difference in NLR between the survival and nonsurvival groups (median [lower quartile–upper quartile], 15.27 [7.92–26.28] vs. 17.97 [8.94–31.85], P = 0.008). Area under the curve (AUC) of NLR on the sixth day was the highest. AUC of NLR was significantly higher in the Simplified Acute Physiological Score (SAPS) 3 ≤52 group than that in the SAPS3 > 52 group (0.78 ± 0.05 vs. 0.69 ± 0.03, P = 0.007). AUC of NLR in the nonshock group was significantly higher than that in the shock group (0.72 ± 0.04 vs. 0.65 ± 0.05, P < 0.01). The ability of NLR as a prognosis predictor of sepsis was influenced by admission time, SAPS3, and shock.

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Lymphocyte-to-monocyte ratio predicts mortality in cirrhotic patients with septic shock

Cited by 14 publications

References 34 publications

Monocytes Subsets Altered Distribution and Dysregulated Plasma hsa-miR-21-5p and hsa- miR-155-5p in HCV-Linked Liver Cirrhosis Progression to Hepatocellular Carcinoma

Monocytes Subsets Altered Distribution and Dysregulated Plasma hsa-miR-21-5p and hsa- miR-155-5p in HCV-Linked Liver Cirrhosis Progression to Hepatocellular Carcinoma

Monocytes subsets altered distribution and dysregulated plasma hsa-miR-21-5p and hsa-miR-155-5p in HCV-linked liver cirrhosis progression to hepatocellular carcinoma

The Influencing Factors of Neutrophil-to-Lymphocyte Ratio as a Prognostic Marker for Sepsis: Analysis from a Large Database

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