Lymphocyte traffic through lymph nodes and Peyer?s patches of the rat: B- and T-cell-specific migration patterns within the tissue, and their dependence on splenic tissue

Blaschke, Volker; Micheel, B; Pabst, Reinhard; Westermann, J

doi:10.1007/s004410050489

Cited by 1 publication

(3 citation statements)

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“…On the basis of these observations, they proposed that T cell and B cell entry into lymphoid tissue is segmentally controlled at the level of HEVs, and that the differential display of chemokines that trigger firm lymphocyte adhesion by HEVs is responsible for this control [46]. However, these results are in sharp contrast to earlier studies in rats showing that T and B cells enter LNs via the same HEVs and that the sorting of T and B cells occurs after they have entered the LNs [123, 125, 126]. Our own data in mice also show that the majority of HEVs express both CCL21 and CXCL13 in both LNs and PPs [56].…”

Section: Remaining Enigmascontrasting

confidence: 56%

“…However, subsequent studies in rats showed the contradictory results that T and B cells entered peripheral LNs and PPs with a similar frequency and that there was no significant difference in the number of T and B cells that interact with HEVs [123, 124]. These findings suggest that, at least in rats, T and B cells enter LNs and PPs without preference.…”

Section: Remaining Enigmasmentioning

confidence: 85%

“…However, studies in rats by Pabst, Westermann, and others [122, 123], who used unseparated cell populations and identified each subset immunohistologically subsequent to the migration, showed that both T and B cells enter various LNs with similar kinetics and in similar numbers, although T cells express L-selectin more abundantly than do B cells in rats [122]. Given these observations, they suggested that if B cells recirculate more slowly than T cells, it might be due to the difference in the retention time of B and T cells in lymphoid tissues rather than to the efficiency of their entry [122, 123]. …”

Section: Remaining Enigmasmentioning

confidence: 99%

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Molecular Determinants Controlling Homeostatic Recirculation and Tissue-Specific Trafficking of Lymphocytes

Tanaka¹,

Ebisuno²,

Kanemitsu³

et al. 2004

Int Arch Allergy Immunol

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The homeostasis of the immune system is maintained by the recirculation of naïve lymphocytes through the secondary lymphoid tissues, such as the lymph nodes, Peyer’s patches, and spleen. Upon insult by pathogens or antigens, lymphocytes become activated, and the regulated trafficking of these cells results in the integration of systemic and regional immune responses. The exquisite specificity of such lymphocyte trafficking is determined by tissue-specific guidance signals expressed by the endothelial cells of postcapillary venules, combined with counterreceptors expressed by the circulating lymphocytes. The high endothelial venules can selectively guide naïve lymphocytes into the lymph nodes and Peyer’s patches by expressing a unique combination of vascular addressins, lymphocyte-specific chemokines, and chemokine-binding molecules. The inflamed postcapillary venules in extralymphoid tissues, such as the skin and intestinal lamina propria, also use a distinct array of endothelial adhesion molecules and tissue- selective chemokines, and support the recruitment of effector and memory lymphocytes that express the appropriate receptors for tissue-specific trafficking. In this review, we summarize the present understanding of the homeostatic recirculation of naïve lymphocytes through the secondary lymphoid tissues and the specific targeting of antigen-experienced lymphocytes into the effector sites. We also revisit some previous studies that reported apparently conflicting observations.

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