Lymphocyte Transformation in Cœliac Disease

Popović, O; Andrejevic, M; Pendić, B.; Lovrić, Lucija; Djordjević, Vladimir

doi:10.1016/s0140-6736(70)91998-7

The Lancet

1970

DOI: 10.1016/s0140-6736(70)91998-7

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Lymphocyte Transformation in Cœliac Disease

O Popović¹,

M Andrejevic²,

B. Pendić³

et al.

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1976

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“…In vivo skin tests of cellmediated immunity (CMI) have not been reported (except to gluten) but several groups (Winter et al, 1967;Blecher et at., 1969;Housley et al, 1969;Ansaldi et al, 1970;Popovic et al, 1970;Maclaurin et at., 1971;Morganroth et at., 1972), have studied lymphocyte transformation in response to PHA which Received for publication 29 June 1976 is the usual in vitro test of CMI. It can be seen (Table 1) that the results are inconclusive.…”

mentioning

confidence: 99%

Depressed cell-mediated immunity in coeliac disease.

Scott¹,

Losowsky²

1976

Gut

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SUMMARY Fourteen coeliac patients on a gluten free diet (GFD) and 10 on a normal diet were studied by lymphocyte transformation in response to PHA to assess the integrity of cell-mediated immunity (CMI). Transformation was depressed in the majority taking a normal diet, with improvement after a GFD. In some patients the depression may have been due to a serum factor, as transformation was more nearly normal when the lymphocytes were cultured in pooled AB serum than in their own serum. There was no correlation between transformation and nutritional deficiencies. Mantoux tests were performed in some of these and other coeliac patients and there was a very significant reduction in the incidence ofpositive tests compared with controls. These findings provide evidence of depressed CMI in coeliac patients taking a normal diet with improvement on a GFD and may be of relevance to the high risk of malignancy in coeliac disease, further strengthening the case for a strict GFD.

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mentioning

confidence: 99%

Depressed cell-mediated immunity in coeliac disease.

Scott¹,

Losowsky²

1976

Gut

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Lymphocyte Transformation in Cœliac Disease

Cited by 1 publication

References 10 publications

Depressed cell-mediated immunity in coeliac disease.

Depressed cell-mediated immunity in coeliac disease.

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