Lymphocyte Transformation in Malnourished Children

Sellmeyer, Erica; Bhettay, E.; As, Truswell; Meyers, O. L.; Hansen, Jo‐Ida C.

doi:10.1136/adc.47.253.429

Cited by 62 publications

(10 citation statements)

References 40 publications

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“…The depression in CMI of professional donors is similar to that which has been observed in protein calorie malnutrition [8,11,13]. blast transformation appeared to have any correlation with the serum albumin or total protein levels.…”

Section: Discussionsupporting

confidence: 62%

“…In recent years, it has become ap parent that malnutrition can result in mul tiple defects of the immune system involving humoral responses, cell-mediated responses, phagocytosis and the complement system [1, 2,8,[11][12][13]. At the same time, cellular components of blood have found an in creasing clinical use in disorders of the hemopoietic system and the immune system.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Cell-Mediated Immunity in Professional and Voluntary Blood Donors

Sharma¹,

Anaraki²,

Harbour³

et al. 1978

Vox Sanguinis

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Cell-mediated immunity (CMI) was compared in professional and voluntary blood donors. Depressed CMI in professional donors was revealed by the presence of significantly lower numbers of positive delayed reactive hypersensitivity responses to Candida albicans, streptokinase and streptodornase, as well as a decrease in lymphoblast transformation response to phytohaemagglutinin. Furthermore, the serum protein and albumin levels in professional donors did not correlate with the depression in CMI. The blood of professional blood donors should be considered to be a poor source of therapeutic immune cell fractions,

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Section: Discussionsupporting

confidence: 62%

Section: Introductionmentioning

confidence: 99%

Cell-Mediated Immunity in Professional and Voluntary Blood Donors

Sharma¹,

Anaraki²,

Harbour³

et al. 1978

Vox Sanguinis

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“…I t has been noted clinically for many years, that macute infection can precipitate overt signs of malnutrition in children, and that malnutrition and infection can interact to intensify the effects of both. The role of the lymphocyte cell system in these interactions has recently been implicated as a major factor (1)(2)(3)(4). The experiments here reported indicate that in a grolwing animal lack of a single dietary factor may allow relatively normal growth until coupled with an acute infectious disease.…”

mentioning

confidence: 67%

The Effect of Vitamin A Deficiency and Newcastle Disease on Lymphoid Cell Systems in Chickens

Bang¹,

Foard²,

Bang³

1973

Experimental Biology and Medicine

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“…Furthermore, there is a failure to reject skin grafts, and, although plasma immunoglobulins are not depressed, the levels of complement are reduced [26]. Lymphocyte transformation rates, after stimulation with phytohemagglutinin, are also reduced in children with protein-calorie malnutrition [5,23]. Smythe and Campbell [25] reported that protein-calorie malnutrition results in a characteristic pattern of infection with symptoms that are typical of conditions in which cell-mediated immunity is abnormal.…”

Section: Introductionmentioning

confidence: 99%

The Cellular Response of the Weanling Rat Thymus Gland to Undernutrition and Rehabilitation

McAnulty

Dickerson

1973

Pediatr Res

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ExtractWeanling male black-hooded rats were maintained at practically constant body weight between 24 and 52 days of age by giving them reduced amounts of their normal diet. Ten animals were then killed at 0, 3, 7, 10, and 16 days of rehabilitation on an ad libitum diet. At each age of rehabilitation, 10 control animals of the same age, and a similar number of the same body weight, were also killed. The thymuses of the animals were assayed for DNA (a measure of cell number), RNA, and protein, and the protein/DNA ratio was calculated (a measure of cell size). The thymus glands were also examined histologically.The thymus lost 81% of its initial weight during undernutrition, but on rehabilitation returned to a normal weight relative to body weight within 10 days, and to a normal weight for age within 16 days. Thereafter it remained of normal weight. The absolute amounts of DNA and RNA responded in a way similar to weight. The absolute amount of protein also decreased during undernutrition, but on rehabilitation showed a poor response during the first 3 days, then increased rapidly to return to normal within 10 days. The protein/DNA ratio showed a sevenfold increase during undernutrition, but returned to normal within 7 days. Thus, atrophy of the thymus during undernutrition was due to a great loss of small cells, which left a population of large cells in the remnant; this was confirmed in histologic sections. However, the thymus had a remarkable capacity for recovery, and the body weight was more important than age as an influence on the rate of recovery. Speculation

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Lymphocyte Transformation in Malnourished Children

Cited by 62 publications

References 40 publications

Cell-Mediated Immunity in Professional and Voluntary Blood Donors

Cell-Mediated Immunity in Professional and Voluntary Blood Donors

The Effect of Vitamin A Deficiency and Newcastle Disease on Lymphoid Cell Systems in Chickens

The Cellular Response of the Weanling Rat Thymus Gland to Undernutrition and Rehabilitation

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