Lymphocytes and nonlymphoid cells in human nasal polyps

Stoop, A. E.; Heijden, H. A. M. D. Van Der; Biewenga, Jeike; Baan, S. Van Der

doi:10.1016/0091-6749(91)90004-8

Cited by 48 publications

(38 citation statements)

References 22 publications

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“…It seems likely that the morphological distribution, localiza tion and tissue concentration in normal nasal mucosa and in nasal polyps is of functional significance [18][19][20][21][22][23].…”

Section: Discussionmentioning

confidence: 99%

Expression of Vasoactive Intestinal Peptide, Substance P and Bombesin-Flanking Peptide in Nasal Polyps

Kuhn

Arnold²

1996

ORL

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The presence of neuropeptide-containing sensory, parasympathetic and sympathetic nerves in human nasal mucosa is well established. However, information regarding the neuropeptide distribution in nasal polyps is still lacking. The aim of this study was to compare immunohistologically the presence and distribution of substance P (SP), vasoactive intestinal peptide (VIP) and bombesin-flanking peptide (BFP) in normal nasal mucosa and nasal polyps. The expression was studied using Formalin-fixed and paraffin-embedded biopsy sections from 20 patients with nasal polyps and 10 controls with normal nasal mucosa from the anterior part of the inferior turbinate. Indirect immunohistochemistry (APAAP method) with mono- and polyclonal antibodies was used. None of the control group but 5 patients of the nasal polyp group had an atopic disease. Comparing localization and intensity of the immunohistological reaction in nasal mucosa and nasal polyp tissue, there was no difference in the expression of the three neuroendocrine substances. There was no difference of expression in the polyposis group itself concerning allergic and nonallergic subjects. The results indicate that VIP, SP and BFP have an equal distribution in nasal polyps and normal nasal mucosa.

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Section: Discussionmentioning

confidence: 99%

Expression of Vasoactive Intestinal Peptide, Substance P and Bombesin-Flanking Peptide in Nasal Polyps

Kuhn

Arnold²

1996

ORL

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“…It has been shown that NPs are usually associated with chronic inflammation of the nasal and paranasal sinus mucosae [8,12,13]. CS patients with persistent mucopurulent nasal dis charges usually have NPs; however, NP formation is not of ten observed on rhinoscopic examination of nasal allergy patients in Japan [8],…”

Section: Discussionmentioning

confidence: 99%

Quantitation and Immunocytological Identification of lnterleukin-1 in Nasal Polyps from Patients with Chronic Sinusitis

Hamaguchi

Suzumura²,

Arima³

et al. 1994

Int Arch Allergy Immunol

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Immunoreactive interleukin-1 (IL-1) α and β levels in nasal polyp (NP) extracts were measured from 22 adult patients with chronic sinusitis (CS) in order to determine their significance in the pathogenesis of NP. The NP sample was separated into mononuclear and polymorphonuclear fractions. In the mononuclear fraction, the mean value of IL-1β was 21.5 pg/ml/g, which was significantly higher than that of IL-1α (8.4pg/ml/g, p < 0.01). In younger adults, the IL-1α and IL-1β levels were 21.2 and 59.4 pg/ml/g, which were significantly higher than those in older CS patients (p < 0.01). There was a significant reverse correlation between patient’s age and IL-1β levels in the mononuclear fraction (r=––0.509, p < 0.01). Immunoreactive IL-1, mainly IL-1β, was identified in the cytoplasmic area of monocytes. A certain amount of immunoreactive IL-1 is produced in mononuclear leukocytes, particularly activated monocytes, and IL-1β production is greater than IL-1α. In younger adult CS patients, NPs contain larger amounts of IL-1β in monocytes, compared to those of older patients.

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“…The inflammatory cellular infiltrate in nasal polyps has been shown to consist of eosinophils, lymphocytes, plasma cells, and mast cells to an extent which is similar to that observed in the bronchial mucosa of asthmatics (2)(3)(4), suggesting that inflammatory mechanisms of the two diseases may be similar (5). According to experimental models, it seems reasonable to speculate that the formation and growth of NPs require ECM accumulation (6).…”

Section: Introductionmentioning

confidence: 99%

Eosinophil Inflammation of Nasal Polyp Tissue: Relationships with Matrix Metalloproteinases, Tissue Inhibitor of Metalloproteinase-1, and Transforming Growth Factor-beta1

Lee

Kim

et al. 2003

J Korean Med Sci

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Eosinophil and mast cell infiltrations are consistent findings in nasal polyp tissue. Previous studies have shown that matrix metalloproteinases (MMPs) may be involved in eosinophil infiltration in airway mucosa of asthmatic patients, and that transforming growth factor-beta1 (TGF-beta1) induces extracellular matrix deposition in nasal polyp tissue. The aim of this study was to evaluate the role of MMPs and tissue-inhibitor of metalloproteinase-1 (TIMP-1) in association with TGF-beta1, eosinophils and mast cell activation in nasal polyp tissue. Nasal polyp tissues from 20 patients who underwent polypectomies were collected and prepared into tissue homogenate. Eosinophil cationic protein (ECP) and tryptase levels were measured by CAP system (Pharmacia, Sweden). MMP-2, MMP-9, TIMP-1 and TGF-beta1 levels were measured by enzyme-liked immunosorbent assay. MMP-2 was the predominant form of MMPs, followed by MMP-9 and TIMP-1. There were significant correlations between ECP, and MMP-9, MMP-2, TGF-beta1 and tryptase, but not with TIMP-1. Significant correlations were noted between tryptase, and MMP-2, MMP-9, and TGF-beta1, but not with TIMP-1. Close correlations were noted between TGF-beta1, and MMP-9 and MMP-2, but not with TIMP-1. MMP-2, MMP-9, and TGF-beta1 may contribute to eosinophil and mast cell migrations into nasal polyp tissue.

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Lymphocytes and nonlymphoid cells in human nasal polyps

Cited by 48 publications

References 22 publications

Expression of Vasoactive Intestinal Peptide, Substance P and Bombesin-Flanking Peptide in Nasal Polyps

Expression of Vasoactive Intestinal Peptide, Substance P and Bombesin-Flanking Peptide in Nasal Polyps

Quantitation and Immunocytological Identification of lnterleukin-1 in Nasal Polyps from Patients with Chronic Sinusitis

Eosinophil Inflammation of Nasal Polyp Tissue: Relationships with Matrix Metalloproteinases, Tissue Inhibitor of Metalloproteinase-1, and Transforming Growth Factor-beta1

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