Lymphocytes in Patients With Ovarian Cancer

Wolff, J. P.; Oliveira, Carlos

doi:10.1097/00006250-197506000-00011

Cited by 13 publications

(5 citation statements)

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“…In 1970, Riesco reported that ALC was positively associated with the "curability" of a variety of cancers [16]. Similar associations between ALC and survival have been reported for a wide variety of epithelial, connective tissue and lymphoid cancers [17], including ovarian cancer [18,19]. In addition to survival, ALC has been associated with response to various cancer treatments, including chemotherapy [20] and autologous hematopoietic stem cell transplantation for hematopoietic [15] and epithelial cancers [21,22].…”

Section: Introductionmentioning

confidence: 72%

Absolute lymphocyte count is associated with survival in ovarian cancer independent of tumor-infiltrating lymphocytes

et al. 2012

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BackgroundThe immune system strongly influences outcome in patients with ovarian cancer. In particular, the absolute lymphocyte count in peripheral blood (ALC) and the presence of tumor-infiltrating lymphocytes (TIL) have each been associated with favourable prognosis. However, the mechanistic relationships between ALC, TIL and prognosis are poorly understood. We hypothesized that high ALC values might be associated with stronger tumor immunity as manifested by increased TIL, decreased tumor burden and longer survival.MethodsALC values were collected from patient records ≥ 2 years before, during or after primary treatment for high-grade serous ovarian cancer (HGSC). Lymphocyte subsets were assessed in peripheral blood by flow cytometry. CD8+ and CD20+ TIL were assessed by immunohistochemistry.ResultsOverall, patients had normal ALC values two or more years prior to diagnosis of HGSC. These values were not predictive of disease severity or survival upon subsequent development of HGSC. Rather, ALC declined upon development of HGSC in proportion to disease burden. This decline involved all lymphocyte subsets. ALC increased following surgery, remained stable during chemotherapy, but rarely recovered to pre-diagnostic levels. ALC values recorded at diagnosis did not correlate with CD8+ or CD20+ TIL but were associated with progression-free survival.ConclusionsPatients with high intrinsic ALC values show no clinical or survival advantage upon subsequent development of HGSC. ALC values at diagnosis are prognostic due to an association with disease burden rather than TIL. Therapeutic enhancement of ALC may be necessary but not sufficient to improve survival in HGSC.

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Section: Introductionmentioning

confidence: 72%

Absolute lymphocyte count is associated with survival in ovarian cancer independent of tumor-infiltrating lymphocytes

et al. 2012

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“…A higher neutrophil count, as well as total white blood cell count (WBC), and a lower lymphocyte count predict poorer survival. [8][9][10][11][12] Notably, Milne et al found that ovarian cancer cases had significantly decreased lymphocytes at diagnosis compared to lymphocyte levels measured two years prior to diagnosis and that the decline was greater in women with higher stage, ascites, and suboptimal debulking. [11] In agreement, we found significantly lower lymphocyte counts and higher neutrophil counts and NLR associated with greater tumor grade and stage, presence of ascites, and bilateral disease.…”

Section: Discussionmentioning

confidence: 99%

“…A higher neutrophil count, as well as total white blood cell count (WBC), and a lower lymphocyte count predict poorer survival. [8][9][10][11][12] That CA125 may bind to certain leukocyte sub-populations suggests a relationship between NLR and CA125 that is much stronger than the two simply being complementary markers. [13] In this study, we have conducted a more detailed examination of pre-operative WBC, differential counts, and the NLR in women with ovarian cancer and their correlations with tumor features, CA125, epidemiologic factors, and overall survival.…”

Section: Introductionmentioning

confidence: 99%

Prognostic significance and predictors of the neutrophil-to-lymphocyte ratio in ovarian cancer

Williams

Labidi-Galy

Terry

et al. 2014

Gynecologic Oncology

156

141

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Objective To investigate the neutrophil-to-lymphocyte ratio (NLR) from peripheral blood, a general measure of inflammation, in ovarian cancer. Methods White cell counts and CA125 levels before treatment, tumor features, and questionnaire data on 519 women with ovarian cancer at two Boston hospitals were recorded. Counts were log-transformed and effects on these by tumor features and epidemiologic variables assessed by analysis of variance and generalized linear models. Cox proportional hazards models were used to assess effects on overall survival. Results Greater NLR was associated with higher tumor stage and grade, presence of ascites, and bilateral disease and correlated with risk factors including Jewish ethnicity, taller height, more ovulatory cycles, and family history of cancer in premenopausal women and talc use in all women. CA125 was positively correlated with neutrophil count, monocyte count, and NLR and inversely correlated with lymphocyte count. In a multivariate adjusted analysis, high NLR predicted poorer survival and high lymphocyte count better survival. Conclusion An elevated NLR before treatment signals more aggressive disease and correlates with risk factors for ovarian cancer. CA125 directly correlates with neutrophils which may reflect secretion of both CA125 and neutrophilic growth factors by the tumor. CA125 inversely correlates with lymphocytes which may reflect the ability of some neutrophilic factors to induce lymphopenia and/or binding of CA125 to lymphocytes removing CA125 from the serum pool. Links between NLR, CA125, and epidemiologic factors may provide new clues about the pathogenesis and progression of ovarian cancer.

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“…Stone et al [12] also demonstrated that anti-IL-6 antibody treatment can suppress the tumor growth by decreasing the platelet counts in ovarian cancer patients. Since Riesco reported that peripheral lymphocytes were positively associated with the Bcurability^of a variety of cancers [34], many studies have suggested that lymphocytes are predictors of survival in ovarian cancer patients [35,36]. T lymphocytes form the major component of the cellular immune response and are essential for anti-tumor immunity [37].…”

Section: Discussionmentioning

confidence: 99%

Preoperative platelet/lymphocyte ratio is a superior prognostic factor compared to other systemic inflammatory response markers in ovarian cancer patients

Zhang

Liu

et al. 2015

Tumor Biol.

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The aim of the present study was to determine the most meaningful preoperative prognostic factor of cancer-related death in ovarian cancer patients by comparing potentially prognostic systemic inflammatory response (SIR) markers. The levels of fibrinogen, albumin, C-reactive protein (CRP), and serum cancer antigen-125 (CA-125) and the neutrophil/lymphocyte ratio (NLR) and platelet/lymphocyte ratio (PLR) were evaluated in 190 ovarian cancer patients to identify predictors of overall survival (OS) and progression-free survival (PFS) using univariate and multivariate analyses. Patients with a PLR >203 had a shorter PFS and OS than the patients in PLR ≤203 group (11 vs. 24 months and 28 vs. 64 months). Univariate analyses revealed that tumor stage, postoperative residual tumor mass, ascites, and the levels of all SIR markers were associated with PFS and OS. Multivariate analysis revealed that PLR was independently associated with PFS (hazard ratio [HR] 1.852, 95% confidence interval [CI] 1.271-2.697, P = 0.001) and OS (HR 2.158, 95%CI 1.468-3.171, P< 0.001), as well as tumor stage and postoperative residual tumor mass. In contrast, fibrinogen remained significant only for PFS (HR 1.724, 95%CI 1.197-2.482, P = 0.003). Patients with a PLR >203 were more prone to have advanced tumor stage (P = 0.002), postoperative residual tumor mass >2 cm (P = 0.032), malignant ascites (P < 0.001), and all the other elevated SIR markers (P < 0.001). Preoperative PLR is superior to other SIR markers (CA-125, NLR, fibrinogen, CRP, and albumin) as a predictor of survival in ovarian cancer patients.

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Lymphocytes in Patients With Ovarian Cancer

Cited by 13 publications

References 0 publications

Absolute lymphocyte count is associated with survival in ovarian cancer independent of tumor-infiltrating lymphocytes

Absolute lymphocyte count is associated with survival in ovarian cancer independent of tumor-infiltrating lymphocytes

Prognostic significance and predictors of the neutrophil-to-lymphocyte ratio in ovarian cancer

Preoperative platelet/lymphocyte ratio is a superior prognostic factor compared to other systemic inflammatory response markers in ovarian cancer patients

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