Lymphocytic Esophagitis: A Rare Disease on the Rise

Shipley, Lindsey C.; Momani, Laith Al; Locke, Allison; Young, Mark

doi:10.7759/cureus.2153

Cited by 2 publications

(1 citation statement)

References 4 publications

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“…In regard to treatment, many of the modalities used in GERD have been utilized, especially proton pump inhibitors (PPIs). The treatment of lymphocytic esophagitis includes symptomatic management such as proton pump inhibitors, swallowed topical steroids, and endoscopic dilation [ 9 , 10 ]. In one prospective study with a follow-up of patients over three years, most had resolution of their symptoms with the use of a PPI [ 2 ].…”

Section: Discussionmentioning

confidence: 99%

Lymphocytic Esophagitis Presenting With Food Impaction

Aboona¹,

Yost²,

Aguon³

et al. 2023

Cureus

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Lymphocytic esophagitis (LyE) is a rare diagnosis made on esophageal biopsy whose pathogenesis is poorly understood. Since its appearance in the literature 15 years ago, it still remains an enigma due to its low prevalence. In this case report, a 71-year-old male presented with an episode of acute dysphagia due to food impaction. Urgent endoscopy was performed to fragment the food bolus. Repeat endoscopy showed a stricture, and lymphocytic esophagitis was found on esophageal biopsy. A proton pump inhibitor (PPI) was initiated with symptomatic improvement. With its increasing prevalence, lymphocytic esophagitis should be on the differential for causes of dysphagia.

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Section: Discussionmentioning

confidence: 99%

Lymphocytic Esophagitis Presenting With Food Impaction

Aboona¹,

Yost²,

Aguon³

et al. 2023

Cureus

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Lymphocytic Esophagitis: A Case Series of Esophageal Disease with Increasing Frequency

Tahan

Yousef

Chela

et al. 2023

RAIAD

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Background: Lymphocytic esophagitis (LE) is a poorly understood clinical finding that has been increasingly identified in the last decade. Previous studies proposed increased frequency of LE in elderly females, as well as associations with smoking and pediatric Crohn’s disease. Objective: We aimed to determine the patient characteristics and clinical features of our adult LE patients. As inflammation in the esophagus has been linked to cancer, this review also describes this association. However, there are no reported cases of malignant transformation in those with underlying lymphocytic esophagitis. Method: We retrospectively reviewed records for patients at the University of Missouri Hospital- Columbia (located in the USA) who had a histopathological diagnosis of LE. Cases of LE were identified using the pathology reporting system at the University of Missouri Hospital for esophageal biopsy specimens for the above-mentioned period. Result: The data of a total of 20 adult cases with esophageal biopsy specimens consistent with LE were included. Conclusions: LE seems to be a benign but disturbing clinical problem and should be remembered in elderly females complaining of dysphagia or refractory reflux symptoms. It has similar endoscopic findings of eosinophilic esophagitis with rings and esophagitis. Smoking and hiatal hernia are common risk factors. The majority of LE patients can respond to proton pump inhibitor (PPI) therapy. Endoscopic dilations and steroid therapy should be considered for PPI nonresponder LE patients.

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Lymphocytic Esophagitis: A Rare Disease on the Rise

Cited by 2 publications

References 4 publications

Lymphocytic Esophagitis Presenting With Food Impaction

Lymphocytic Esophagitis Presenting With Food Impaction

Lymphocytic Esophagitis: A Case Series of Esophageal Disease with Increasing Frequency

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