Lymphocytic Infiltration of Skin

Comparison of histopathologic–clinical characteristics of Jessner's lymphocytic infiltration of the skin and lupus erythematosus tumidus: Multicenter study of 46 cases

“…The notion of photosensitivity in JLIS was raised early 5,25 and was shown by Toonstra et al 3 to occur in 24% of cases. More recently, Weber et al, 26 described 10 cases of photo-induced JLIS, with appearance of the lesions delayed 3 to 6 days after exposure, with combined UVA and UVB triggering spectra for most patients, as confirmed further by our group.…”

“…[1][2][3][4][5][6] Histologic examination of skin lesions found perivascular or periadnexal lymphocyte infiltration under a usually normal or only slight modified epidermis, [1][2][3][4] although it is sometimes difficult to distinguish it from polymorphic light eruption, 3,5 certain pseudolymphomas, 6,7 or chronic cutaneous lupus erythematosus (CCLE), 5,8-10 the latter being differentiated by the absence of epidermal changes, the cellular composition of its inflammatory infiltrate, and its respect of the dermoepidermal junction. Lupus erythematosus tumidus (LET) is considered to be a purely dermal form of CCLE, for which the clinical and histopathologic differential diagnosis is much more difficult.…”

Jessner and Kanof’s Lymphocytic Infiltration of the Skin: A Familial Variant

“…Many dermatologists now accept this clinicopathological entity and long-term follow-up has confirmed its dis tinctive histological and clinical features [4,5]. The characteristic lesions are asymp tomatic, papular/nodular lesions classically affecting the face although other body sites such as the trunk may be involved.…”

La variété médio-dorsale de l’infiltration lymphocytaire de la peau (Jessner et Kanof)

“…L'inefficacité des antipaludéens de synthèse, les rémissions spontanées, l'absence de syndrome biologique, le caractère migrant de l'éruption, l'ab sence d'immuno-globulines fixées sur la membrane basale [7,10,18,24], l'absence de cicatrice, sont suffisamment d'arguments à l'encontre de la moindre parenté nosologique avec le LEC. L'histologie, malgré une certaine ressemblance, confirme la distinction, en particulier par l'intégrité du derme papillaire et surtout de l'épiderme.…”